Isolation, catalytic properties, and competitive inhibitors of the zinc-dependent murine glutaminyl cyclase

Biochemistry

Volumn 44, Issue 40, 2005, Pages 13415-13424

  Schilling, Stephan ^a   Cynis, Holger ^a   Von Bohlen, Alex ^b   Hoffmann, Torsten ^a   Wermann, Michael ^a   Heiser, Ulrich ^a   Buchholz, Mirko ^a   Zunkel, Katrin ^a   Demuth, Hans Ulrich ^a  

^a PROBIODRUG AG   (Germany)

^b LEIBNIZ INSTITUT FÜR ANALYTISCHE WISSENSCHAFTEN ISAS E V   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; FERMENTATION; NETWORK PROTOCOLS; PROTEINS; SPECTROMETRY; SPECTROSCOPY; SUBSTRATES; X RAYS; ZINC;

CATALYTIC MECHANISM; CATALYTIC PROPERTIES; ENZYMETIC ACTIVITY; ISOLATION;

CATALYSIS;

1,10 PHENANTHROLINE; 8 QUINOLINOL; CITRIC ACID; COMPLEMENTARY DNA; DIPICOLINIC ACID; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MERCAPTAMINE; PROTEINASE; THIOL DERIVATIVE; ZINC;

ARTICLE; ATOMIC ABSORPTION SPECTROMETRY; BINDING SITE; CATALYSIS; CELL LINE; ENZYME ACTIVITY; ENZYME INHIBITION; FERMENTATION; INSULINOMA; METAL BINDING; MOLECULAR CLONING; NONHUMAN; PH; PICHIA PASTORIS; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; X RAY FLUORESCENCE; YEAST;

AMINO ACID SEQUENCE; AMINOACYLTRANSFERASES; ANIMALS; BINDING SITES; CATALYSIS; CATTLE; CITRIC ACID; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; HUMANS; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KINETICS; MICE; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; NITROGEN; PHOTONS; PICHIA; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; SUBSTRATE SPECIFICITY; TIME FACTORS; ZINC;

ANIMALIA; MURINAE; PICHIA PASTORIS;

EID: 26444568143     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi051142e     Document Type: Article

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