Transcriptome profiling of endothelial cells during infections with high and low densities of C. albicans cells

International Journal of Medical Microbiology

Volumn 301, Issue 6, 2011, Pages 536-546

  Lim, Crystale S Y ^a   Rosli, Rozita ^a   Seow, Heng Fong ^a   Chong, Pei Pei ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

Candida albicans; Cell density; Endothelial cells; Gene expression; Hyphae; Yeast

Indexed keywords

TRANSCRIPTOME;

APOPTOSIS; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL DEATH; CELL DENSITY; CELL INTERACTION; CELL VIABILITY; CONTROLLED STUDY; FUNGAL CELL; FUNGUS HYPHAE; HUMAN; HUMAN CELL; NONHUMAN; RNA FINGERPRINTING; UMBILICAL VEIN ENDOTHELIAL CELL;

APOPTOSIS; CANDIDA ALBICANS; CELL COUNT; CELL SURVIVAL; GENE DELETION; HOST-PATHOGEN INTERACTIONS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYPHAE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; TRANSCRIPTOME;

EID: 79960248741     PISSN: 14384221     EISSN: 16180607     Source Type: Journal    
DOI: 10.1016/j.ijmm.2010.12.002     Document Type: Article

References (27)

1. Barker K.S., Park H., Phan Q.T., Homayouni R., Rogers P.D., Filler S.G. Transciptome profile of the vascular endothelial cell response to Candida albicans. J. Infect. Dis. 2008, 198:193-202.
2. Braun B.R., Johnson A.D. Control of filament formation in Candida albicans by the transcriptional repressor TUP1. Science 1997, 277:105-109.
3. Braun B.R., Head W.S., Wang M.X., Johnson A.D. Identification and characterization of TUP1-regulated genes in Candida albicans. Genetics 2000, 156:31-44.
4. Bendel C.M., Hess D.J., Garni R.M., Henry-Stanley M., Wells C.L. Comparative virulence of Candida albicans yeast and filamentous forms in orally and intravenously inoculated mice. Crit. Care Med. 2003, 31:501-507.
5. Chen C.G., Yang Y.L., Cheng H.H., Su C.L., Huang S.F., Chen C.T., Liu Y.T., Su I.J., Lo H.J. Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection. Int. J. Immunopathol. Pharmacol. 2006, 19:561-565.
6. Chibana H., Uno J., Cho T., Mikami Y. Mutation in IRO1 tightly linked with URA3 gene reduces virulence in Candida albicans. Microbiol. Immunol. 2005, 49:937-939.
7. Evans Z.A. Tissue responses to the blastospores and hyphae of Candida albicans in the mouse. J. Med. Microbiol. 1980, 14:307-319.
8. Garcia M.G., O'Connor J.E., Garcia L.L., Martinez S.I., Herrero E., del Castillo Agudo L. Isolation of a Candida albicans gene, tightly linked to URA3, coding for a putative transcription factor that suppresses a Saccharomyces cerevisiae aft1 mutation. Yeast 2001, 18:301-311.
9. Grubb S.E.W., Murdoch C., Sudbury P., Saville S.P., Lopez-Ribot J.L., Thornhill M.H. Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis. Infect. Immun. 2008, 76:4370-4377.
10. Grubb S.E.W., Murdoch C., Sudbury P., Saville S.P., Lopez-Ribot J.L., Thornhill M.H. Adhesion of Candida albicans to endothelial cells under physiological conditions of flow. Infect. Immun. 2009, 77:3872-3878.
11. Hazan I., Sepulveda-Becerra M., Liu H. Hyphal elongation is regulated independently of cell cycle in Candida albicans. Mol. Biol. Cell 2002, 13:134-145.
12. Kruppa M. Quorum sensing and Candida albicans. Mycoses 2008, 52:1-10.
13. Kulkarni R.K., Nickerson K.W. Nutritional control of dimorphism in Ceratocystis ulmi. Exp. Mycol. 1981, 5:148-154.
14. Laprade L., Boyartchuk V.L., Dietrich W.F., Winston F. Spt3 plays opposite roles in filamentous growth in Saccharomyces cerevisiae and Candida albicans and is required for C. albicans virulence. Genetics 2002, 161:509-519.
15. Lo H.J., Köhler J.R., DiDomenico B., Loebenberg D., Cacciapuoti A., Fink G. Nonfilamentous C. albicans mutants are avirulent. Cell 1997, 90:939-949.
16. Orozco A.S., Zhou X., Filler S.G. Mechanisms of the proinflammatory response of endothelial cells to Candida albicans infection. Infect. Immun. 2000, 68:1134-1141.
17. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001, 29:2002-2007.
18. Pfaller M.A. Nosocomial candidiasis: emerging species, reservoirs and modes of transmission. Clin. Infect. Dis. 1996, 22:589-594.
19. Pfaller M.A., Diekema D.J. Epidemiology of invasive candidiasis: a persistent public health problem. Clin. Microbiol. Rev. 2007, 20:133-163.
20. Phan Q.T., Belanger P.H., Filler S.G. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infect. Immun. 2000, 68:3485-3490.
21. Saville S.P., Lazzell A.L., Monteagudo C., Lopez-Ribot J.L. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell. 2003, 2:1053-1060.
22. Spellberg B.J., Johnston D.A., Phan Q.T., Edwards J.E.J., French S.W., Ibrahim A.S., Filler S.G. Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis. Infect. Immun. 2003, 71:5756-5764.
23. Staab J.F., Sundstrom P. URA3 as a selectable marker for disruption and virulence assessment of Candida albicans genes. Trends Microbiol. 2003, 11:69-73.
24. Sudbery P., Gow N., Berman J. The distinct morphogenic states of Candida albicans. Trends Microbiol. 2004, 12:317-324.
25. Todeschini G.T. Treatment of candidiasis: a perspective on recent advances and future challenges. Int. J. Infect. Dis. 1997, 1:S37-S41.
26. Villar C.C., Kashleva H., Mitchell A.P., Dongari-Bagtzoglou A. Invasive phenotype of Candida albicans affects the host proinflammatory response to infection. Infect. Immun. 2005, 73:4588-4595.
27. Wisplinghoff H., Bischoff T., Tallent S.M., Seifert H., Wenzel R.P., Edmond M.B. Nosocomial bloodstream infections in US hospitals: analysis of 24,179 cases from a prospective nationwide surveillance study. Clin. Infect. Dis. 2004, 39:309-317.