Adhesion of Candida albicans to endothelial cells under physiological conditions of flow

Infection and Immunity

Volumn 77, Issue 9, 2009, Pages 3872-3878

  Grubb, Sarah E W ^a,c   Murdoch, Craig ^a   Sudbery, Peter E ^a   Saville, Stephen P ^b   Lopez Ribot, Jose L ^b   Thornhill, Martin H ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b UNIVERSITY OF TEXAS AT SAN ANTONIO   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANDIDA ALBICANS; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; ENDOTHELIUM CELL; FLOW RATE; FUNGUS CULTURE; FUNGUS HYPHAE; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; SHEAR STRESS; VENULE;

ADHESIVENESS; CANDIDA ALBICANS; CELL LINE; ENDOTHELIAL CELLS; HUMANS; HYPHAE; SHEAR STRENGTH;

EID: 69049098957     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00518-09     Document Type: Article

References (28)

1. Ades, E. W., F. J. Candal, R. A. Swerlick, V. G. George, S. Summers, D. C. Bosse, and T. J. Lawley. 1992. HMEC-1: establishment of an immortalized human microvascular endothelial cell line. J. Investig. Dermatol. 99:683-690.
2. Atherton, A., and G. V. Born. 1972. Quantitative investigations of the adhesiveness of circulating polymorphonuclear leucocytes to blood vessel walls. J. Physiol. 222:447-474.
3. Bendel, C. M., D. J. Hess, R. M. Garni, M. Henry-Stanley, and C. L. Wells. 2003. Comparative virulence of Candida albicans yeast and filamentous forms in orally and intravenously inoculated mice. Crit. Care Med. 31:501-507.
4. Chen, C. G., Y. L. Yang, H. H. Cheng, C. L. Su, S. F. Huang, C. T. Chen, Y. T. Liu, I. J. Su, and H. J. Lo. 2006. Non-lethal Candida albicans cph1/cph1 efg1/efg1 transcription factor mutant establishing restricted zone of infection in a mouse model of systemic infection. Int. J. Immunopathol. Pharmacol. 19:561-565.
5. Evans, Z. A., and D. N. Mardon. 1977. Organ localization in mice challenged with a typical Candida albicans strain and a pseudohyphal variant. Proc. Soc. Exp. Biol. Med. 155:234-238.
6. Filler, S. G., J. N. Swerdloff, C. Hobbs, and P. M. Luckett. 1995. Penetration and damage of endothelial cells by Candida albicans. Infect. Immun. 63:976-983.
7. Fonzi, W. A., and M. Y. Irwin. 1993. Isogenic strain construction and gene mapping in Candida albicans. Genetics 134:717-728.
8. Glee, P. M., J. E. Cutler, E. E. Benson, R. F. Bargatze, and K. C. Hazen. 2001. Inhibition of hydrophobic protein-mediated Candida albicans attachment to endothelial cells during physiologic shear flow. Infect. Immun. 69:2815-2820.
9. Gow, N. A., A. J. Brown, and F. C. Odds. 2002. Fungal morphogenesis and host invasion. Curr. Opin. Microbiol. 5:366-371.
10. Grubb, S. E., C. Murdoch, P. E. Sudbery, S. P. Saville, J. L. Lopez-Ribot, and M. H. Thornhill. 2008. Candida albicans-endothelial cell interactions: a key step in the pathogenesis of systemic candidiasis. Infect. Immun. 76:4370-4377.
11. Hadley, S., W. W. Lee, R. Ruthazer, and S. A. J. Nasraway. 2002. Candidemia as a cause of septic shock and multiple organ failure in nonimmunocompromised patients. Crit. Care Med. 30:1808-1814.
12. Heisig, N. 1968. Functional analysis of the microcirculation in the exocrine pancreas. Adv. Microcirc. 1:89-94.
13. Kozinn, P. J., C. L. Taschdjian, B. E. Kodsi, G. J. Wise, M. S. Seeling, and P. K. Goldberg. 1982. Diagnosis of systemic or visceral candidosis. Can. Med. Assoc. J. 126:1386-1390.
14. Lawrence, M. B. 1999. Selectin-carbohydrate interactions in shear flow. Curr. Opin. Chem. Biol. 3:659-664.
15. Lawrence, M. B., L. V. McIntire, and S. G. Eskin. 1987. Effect of flow on polymorphonuclear leukocyte/endothelial cell adhesion. Blood 70:1284-1290.
16. Lawrence, M. B., and T. A. Springer. 1991. Leukocytes roll on a selectin at physiologic flow rates: distinction from and prerequisite for adhesion through integrins. Cell 65:859-873.
17. Lipowsky, H. H. 1995. Shear stress in the circulation, p. 28-45. In J. A. Bevan (ed.), Flow-dependent regulation of vascular function. Oxford University Press, Oxford, United Kingdom.
18. MacCallum, D. M., and F. C. Odds. 2005. Temporal events in the intravenous challenge model for experimental Candida albicans infections in female mice. Mycoses 48:151-161.
19. Phan, Q. T., P. H. Belanger, and S. G. Filler. 2000. Role of hyphal formation in interactions of Candida albicans with endothelial cells. Infect. Immun. 68:3485-3490.
20. Rotrosen, D., J. E. J. Edwards, T. R. Gibson, J. C. Moore, A. H. Cohen, and I. Green. 1985. Adherence of Candida to cultured vascular endothelial cells: mechanisms of attachment and endothelial cell penetration. J. Infect. Dis. 152:1264-1274.
21. Sanchez, A. A., D. A. Johnston, C. Myers, J. E. J. Edwards, A. P. Mitchell, and S. G. Filler. 2004. Relationship between Candida albicans virulence during experimental hematogenously disseminated infection and endothelial cell damage in vitro. Infect. Immun. 72:598-601.
22. Sanglard, D., and F. C. Odds. 2002. Resistance of Candida species to antifungal agents: molecular mechanisms and clinical consequences. Lancet Infect. Dis. 2:73-85.
23. Saville, S. P., A. L. Lazzell, C. Monteagudo, and J. L. Lopez-Ribot. 2003. Engineered control of cell morphology in vivo reveals distinct roles for yeast and filamentous forms of Candida albicans during infection. Eukaryot. Cell 2:1053-1060.
24. Spellberg, B. J., D. A. Johnston, Q. T. Phan, J. E. J. Edwards, S. W. French, A. S. Ibrahim, and S. G. Filler. 2003. Parenchymal organ, and not splenic, immunity correlates with host survival during disseminated candidiasis. Infect. Immun. 71:5756-5764.
25. Sudbery, P. E., N. A. Gow, and J. Berman. 2004. The distinct morphogenic states of Candida albicans. Trends Microbiol. 12:317-324.
26. Todeschini, G. T. 1997. Treatment of candidiasis: a perspective on recent advances and future challenges. Int. J. Infect. Dis. 1:S37-S41.
27. Wey, S. B., M. Mori, M. A. Pfaller, R. F. Woolson, and R. P. Wenzel. 1988. Hospital-acquired candidemia. The attributable mortality and excess length of stay. Arch. Intern. Med. 148:2642-2645.
28. Zhao, X., S. H. Oh, G. Cheng, C. B. Green, J. A. Nuessen, K. Yeater, R. P. Leng, A. J. Brown, and L. L. Hoyer. 2004. ALS3 and ALS8 represent a single locus that encodes a Candida albicans adhesin; functional comparisons between Als3p and Als1p. Microbiology 150:2415-2428.