Liquorice and its health implications

Journal of The Royal Society for the Promotion of Health

Volumn 120, Issue 2, 2000, Pages 83-89

  Olukoga, Adebayo ^a   Donaldson, David ^b,c  

^a East Surrey Hospital ^*  (United Kingdom)

^b EAST SURREY HOSPITAL   (United Kingdom)

^c Crawley Hospital   (United Kingdom)

Author keywords

Commercial use; Glycyrrhizinic acid (GZA); Liquorice; Medicinal value; Metabolic consequences

Indexed keywords

ANTACID AGENT; CARBENOXOLONE; CHALCONE DERIVATIVE; DEGLYCYRRHIZINATED LIQUORICE; GLYCYRRHIZIC ACID; MINERALOCORTICOID; MINERALOCORTICOID RECEPTOR;

DISEASE ASSOCIATION; DRUG EFFECT; DRUG MECHANISM; DRUG USE; EDEMA; GLYCYRRHIZA; HEPATITIS B; HUMAN; HYPERALDOSTERONISM; HYPERTENSION; HYPOKALEMIA; METABOLIC BALANCE; NONHUMAN; PEPTIC ULCER; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; SODIUM RETENTION;

EID: 0033924620     PISSN: 14664240     EISSN: None     Source Type: Journal    
DOI: 10.1177/146642400012000203     Document Type: Review

References (57)

1. ARMANINI D, KARBOWIAK I and FUNDER J W (1983). Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors. Clin Endocrinol; 19, 609-612
2. ARMANINI D, BONANNI G and PALERMO M (1999). Reduction of serum testosterone in men by licorice. NEJM; 341(15) ,1158
3. ARRIZA J L, WEINBERGER C, CERELLI G, GLASER T M, HANDELIN B L, HOUSMAN D E and EVANS R M (1987). Cloning of human mineralocorticoid receptor complementary DNA: structural and functional kinship with the glucocorticoid receptor. Science; 237, 268-275
4. BAKER M E (1994). Licorice and enzymes other than 11β-hydroxysteroid dehydrogenase: an evolutionary perspective. Steroids; 59, 136-141
5. BANNISTER B, GINSBURGH R and SHNEERSON J (1977). Cardiac arrest due to liquorice-induced hypokalaemia. BMJ; 2, 738-739
6. BARRELLA M, LAURIA G, QUATRALE R and PAOLINO E (1997). Hypokalaemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Ital J Neurol Sci; 18, 217-220
7. BENEDIKTSSON R and EDWARDS C R (1994). Apparent mineralocorticoid excess. J Human Hypertension; 8, 371-375
8. BERNARDI M, D'INTINO P E, TREVISANI F, CANTELLI-FORTI G, RAGGI M A, TURCHETTO E and GASBARRINI G (1994). Effects of prolonged ingestion of graded doses of licorice by health volunteers. Life Sciences; 55, 863-872
9. BLACHLEY J D and KNOCHEL J P (1980). Tobacco chewer's hypokalaemia - licorice revisited. N Engl J Med; 302, 784-785
10. BORST J G G, HOLT S P, de VRIES L A and MOLHUYSEN J A (1953). Synergistic action of liquorice and cortisone in Addison's and Simmonds's disease. Lancet; 1: 657-663
11. BROWN H M, CHRISTIE B G B, COLINJONES E, FINNEY R S H, MacGREGOR W G, SMITH J M, SMITH J M, SMITH W G, TARNOKY A L, TURNER E E, WOTTON D E M and WATKINSON G (1959). Glycyrrhetinic acid hydrogen succinate (disodium salt): a new anti-inflammatory compound. Lancet; 2, 492-493
12. CARD W I, MITCHELL W, STRONG J A, TAYLOR N R W, TOMPSETT S L and WILSON J M G (1953). Effects of liquorice and its derivatives on salt and water metabolism. Lancet; 2, 663-667
13. CATALOG F, DI-STEFANO P, VIOLANTE M, TRAVERSO G and MUL'E M (1997). Pseudohyperaldosteronism secondary to liquorice poisoning associated with haemorrhagic gastritis. Pediatr Med Chir; 19, 219-221
14. CEREDA J M, TRONO D and SCHIFFERLI J (1983). Liquorice intoxication caused by alcohol-free pastis. Lancet; 1, 1442
15. CHAMBERLAIN T J (1970). Licotice poisoning, pseudoaldosteronism and heart failure. JAMA; 213, 1343
16. CHEN M, THEANDER T G, CHRISTENSEN S B, HVIID L, ZHAI L and KHARAZMI A (1994). Licochalcone A, a new anti-malarial agent, inhibits in-vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection. Antimicrobial Agents and Chemotherapy, 38, 1470-1475
17. CHRISTENSEN S B, MING C, ANDERSEN L, HJORNE U, OLSEN C E, CORNETT C, THEANDER T G and KHARAZMI A (1994). An anti-leishmanial chalcone from Chinese licorice roots. Planta Medica; 60, 121-123
18. CLYBURN E B and DIPETTE D J (1995). Hypertension induced by drugs and other substances. Semin Nephrol; 15, 72-86
19. CUMMING A M M, BODDY K, BROWN J J, FRASER R, LEVER A F, PADFIELD P L and ROBERTSON J I (1980). Severe hypokalaemia with paralysis induced by small doses of liquorice. Postgrad Med J; 56, 526-529
20. DAVIS E A and MORRIS D J (1991). Medicinal uses of licorice through the millennia: the good and plenty of it. Moll Cell Endocrine; 78, 1-6
21. DOLL R, HILL I D, HUTTON C and UNDERWOOD D J (1962). Clinical trial of a triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet; 2, 793-796
22. EDWARDS C R W, STEWART P M, BURT D, BRETT L, McINTYRE M A, SUTANTO W S, de KLOET E R and MONDER C (1988). Localisation of 11β-hydroxysteroid dehydrogenase tissue-specific protector for the mineralocorticoid receptor. Lancet; 1, 986-989
23. EPSTEIN M T, ESPINER E A, DONALD R A and HUGHES H (1977). Liquorice toxicity and the renin-angiotensin-aldosterone axis in man. BMJ; 1, 209-210
24. EPSTEIN M I, ESPINER E A, DONALD R A, HUGHES H, COWLES R J and LUN S (1978). Licorice raises urinary cortisol in man. J Clin Endocrinol Metab; 47, 397-400
25. FARESE R V, BIGLIERI E G, SHACKLETON C H L, IRONY I and GOMEZ-FONTES R (1991). Licorice-induced hypermineralocorticoidism. N Engl J Med; 325, 1223-1227
26. FUNDER J W, PEARCE P T, SMITH R and SMITH A I (1988). Mineralocorticoid action: target tissue specificity is enzyme, not receptor, mediated. Science; 242, 583-586
27. GIBSON M R (1978). Glycyrrhiza in old and new perspectives. Lloyda; 41, 348-354
28. HABERER J P, JOUVE P, BEDOCK B and BAZIN P E (1984). Severe hypokalaemia secondary to over-indulgence in alcohol-free 'pastis'. Lancet; 1, 1305
29. HERMESSE B, COLLINGE A and NOIRFALISE A (1986). Taux de glycyrrhizine présents dans quelques dendrées alimentaires. Archives de Médecine Sociale et d'Hygiene; 44, 60-67
30. JONES F A (1968). General introduction. In: A symposium on carbenoxolone sodium, pp 1-4. (JM Robson and FM Sullivan, eds). London: Butterworth
31. KATO H, KANAOKA M, YANO S and KOBAYASHI M (1995). 3-monoglucuronylglycyrrhetinic acid is a major metabolite that causes liquorice-induced pseudoaldosteronism. J Clin Endocrinol Metab; 80, 1929-1933
32. de KLERK G J, NIEUWENHUIS M G and BEUTLER J J (1997). Hypokalaemia and hypertension associated with use of liquorice flavoured chewing gum. BMJ; 314, 731-732
33. KOBAYASHI S, MIYAMOTO T, KIMURA I and KIMURA M (1995). Inhibitory effect of isoliguiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro. Biological and Pharmaceutical Bulletin; 18, 1382-1386
34. LAI F, VENNA N, ARRIGG F Jr and SABIN T D (1980). Licorice, snuff and hypokalaemia. N Engl J Med; 303, 463
35. MOLHUYSEN J A, GERBRANDY J, de VRIES L A, de JONG J C, LENSTRA J B, TURNER K P and BORST J G T (1950). A liquorice extract with deoxycortone-like action. Lancet; 2, 381-386
36. MONDER C, STEWART P M, LAKSHMI V, VALENTINO R, BURT D and EDWARDS C R (1989). Licorice inhibits corticosteroid 11b-dehydrogenase of rat kidney and liver: in vivo and in vitro studies. Endocrinology; 125, 1046-1053
37. MONDER C (1991). Corticosteroids, receptors and the organ-specific functions of 11β-hydroxysteroid dehydrogenase. FASEB J; 5, 3047-3051
38. NIELSEN I and PEDERSEN R S (1984). Life threatening hypokalaemia caused by liquorice ingestion. Lancet; 1, 1305
39. NIGHTINGALE S, SMITH P E and TURNBULL D M (1981). Anorexia nervosa, liquorice and hypokalaemic myopathy. Postgrad Med J; 57, 577-579
40. OLUKOGA A and DONALDSON D (1998). The history of liquorice: the plant, its extract, cultivation, commercialisation and etymology. J Roy Soc Health; 118(5), 300-304
41. PALERMO M, SHACKLETON C H, MANTERO F and STEWART P M (1996). Urinary free cortisone and the assessment of 11β-hydroxysteroid dehydrogenase activity in man. Clin Endocrinol; 45, 605-611
42. PESKAR B M, HOLLAND A and PESKAR B A (1976). Effect of carbenoxolone on prostaglandin synthesis and degradation. J Pharm Pharmacol; 28, 146-148
43. PINDER R M, BROGDEN R N, SAWYER P R, SPEIGHT T M, SPENCER R and AVERY G S (1976). Carbenoxolone: a review of its pharmacological properties and therapeutic efficacy in peptic ulcer disease. Drugs; 11, 245-307
44. REEVERS F E (1948). De behandeling von ulcus ventriculi en ulcus duodenei met succus liquiritieae. Ned Tijdschr Geneeskd; 92, 2968-2971
45. REYNOLDS JEF (1993). Martindale: the extra pharmacopoeia. 13th Ed. pp 888, 2171-2172. London: Pharmaceutical Press
46. ROSSEEL M and SCHOORS D (1993). Chewing gum and hypokakemia. Lancet; 341, 175
47. SAITO T, TSUBOI Y, FUJISAWA G, SAKUMA N, HONDA K, OKADA K, SAITO K, ISHIKAWA S and SAITO T (1994). An autopsy case of licorice-induced hypokalaemic rhabdomyolysis associated with acute renal failure: special reference to profound calcium deposition in skeletal and cardiac muscle. Jap J Neph; 36, 1308-1314
48. SATO H, GOTO W, YAMAMURA J, KUROKAWA M, KAGEYAMA S, TAKAHARA T, WATANABE A and SHIRAKI K (1996). Therapeutic basis of glycyrrhizin on chronic hepatitis B. Antiviral Research; 30, 171-177
49. SECKL J R (1997). 11β-hydroxysteroid dehydrogenase in the brain: a novel regulator of glucocorticoid action? Frontiers in Neuroendocrinology, 18, 49-99
50. SHIMOJO M and STEWART P M (1995). Apparent mineralocorticoid excess syndromes. J Endocrinol Invest; 18, 518-532
51. SPINKS E A and FENWICK G R (1990). The determination of glycyrrhizin in selected UK liquorice products. Food Addit Contam; 7, 769-778
52. STEWART P M, WALLACE A M, VALENTINI R, BURT D, SHACKLETON C H L and EDWARD CRW (1987). Mineralocorticoid activity of liquorice: 11β-hydroxysteroid dehydrogenase deficiency comes of age. Lancet; 2, 821-824
53. STORMER F C, REISTAD R and ALEXANDER J (1993). Glycyrrhizic acid in liquorice - evaluation of health hazard. Food and Chemical Toxicol; 31, 303-312
54. TAKAHARA T, WATANABE A and SHIRAKI K (1994). Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. J Hepatol; 21, 601-609
55. WALKER B R and EDWARDS C R (1994). Licorice-induced hypertension and syndromes of apparent mineralocorticoid excess. Endocrinol Metab Clin North America; 23, 359-377
56. WERNER S, BRISMAR K and OLSSON S (1979). Hyperprolactinaemia and liquorice. Lancet; 1, 319
57. van der ZWAN A (1993). Hypertension encephalopathy after liquorice ingestion. Clin Neurol Neurosurg; 95, 35-37