Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-κB and AP-1

Phytotherapy Research

Volumn 24, Issue SUPPL. 1, 2010, Pages

  Park, Sun Hong ^b   Kang, Jong Soon ^a   Yoon, Yeo Dae ^a   Lee, Kiho ^a   Kim, Kang Jeon ^a   Lee, Ki Hoon ^a   Lee, Chang Woo ^a   Moon, Eun Yi ^c   Han, Sang Bae ^d   Kim, Bong Hee ^b   Kim, Hwan Mook ^a   Park, Song Kyu ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b Chungnam National University   (South Korea)

^c Sejong University   (South Korea)

^d Chungbuk National University   (South Korea)

Author keywords

Glabridin; Interleukin 1 ; Lipopolysaccharide; Microglia; Nitric oxide; Tumor necrosis factor

Indexed keywords

GLABRIDIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MESSENGER RNA; NITRIC OXIDE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL ACTIVATION; CELL PROTECTION; CONCENTRATION RESPONSE; DNA BINDING; ENCEPHALITIS; GENE EXPRESSION REGULATION; INFLAMMATORY CELL; INHIBITION KINETICS; MICROGLIA; MOUSE; NEUROPROTECTION; NONHUMAN;

ANIMALS; CELL LINE; INTERLEUKIN-1BETA; ISOFLAVONES; LIPOPOLYSACCHARIDES; MICE; MICROGLIA; NF-KAPPA B; NITRIC OXIDE; PHENOLS; TRANSCRIPTION FACTOR AP-1; TUMOR NECROSIS FACTOR-ALPHA;

GLYCYRRHIZA; MURINAE;

EID: 75749104978     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2872     Document Type: Article

References (27)

1. Belinky PA, Aviram M, Fuhrman B, Rosenblat M, Vaya J. 1998. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis 137: 49-61.
2. Block ML, Zecca L, Hong JS. 2007. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69.
3. Chomczynski P, Mackey K. 1995. Substitution of chloroform by bromo-chloropropane in the single-step method of RNA isolation. Anal Biochem 225: 163-164.
4. Dawson VL, Brahmbhatt HP, Mong JA, Dawson TM. 1994. Expression of inducible nitric oxide synthase causes delayed neurotoxicity in primary mixed neuronal-glial cortical cultures. Neuropharmacology 33: 1425-1430.
5. Fuhrman B, Buch S, Vaya J et al. 1997. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 66: 267-275.
6. Fukai T, Satoh K, Nomura T, Sakagami H. 2003. Preliminary evaluation of antinephritis and radical scavenging activities of glabridin from Glycyrrhiza glabra. Fitoterapia 74: 624-629.
7. Ghosh S, May MJ, Kopp EB. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260.
8. Hiscott J, Marois J, Garoufalis J et al. 1993. Characterization of a functional NF-κB site in the human interleukin 1β promoter: evidence for a positive autoregulatory loop. Mol Cell Biol 13: 6231-6240.
9. Kang JS, Jeon YJ, Kim HM, Han SH, Yang KH. 2002. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. J Pharmacol Exp Ther 302: 138-144.
10. Kang JS, Yoon YD, Cho IJ et al. 2005. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock. J Pharmacol Exp Ther 312: 1187-1194.
11. Kang JS, Yoon YD, Han MH et al. 2006. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-α-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-κB/Rel signaling pathways. Mol Pharmacol 69: 941-949.
12. Kang JS, Yoon YD, Lee KH, Park SK, Kim HM. 2004. Costunolide inhibits interleukin-1β expression by down-regulation of AP-1 and MAPK activity in LPS-stimulated RAW 264.7 cells. Biochem Biophys Res Commun 313: 171-177.
13. Kogut MH, Genovese KJ, He H, Kaiser P. 2008. Flagellin and lipopolysaccharide up-regulation of IL-6 and CXCLi2 gene expression in chicken heterophils is mediated by ERK1/2-dependent activation of AP-1 and NF-κB signaling pathways. Innate Immun 14: 213-222.
14. Kwon HS, Oh SM, Kim JK. 2008. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis. Clin Exp Immunol 151: 165-173.
15. Liu B, Hong JS. 2003. Role of microglia in inflammation-mediated neurodegenerative diseases: mechanisms and strategies for therapeutic intervention. J Pharmacol Exp Ther 304: 1-7.
16. Lowenstein CJ, Alley EW, Raval P et al. 1993. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc Natl Acad Sci USA 90: 9730-9734.
17. Meda L, Cassatella MA, Szendrei GI et al. 1995. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 374: 647-650.
18. Perry VH, Gordon S. 1988. Macrophages and microglia in the nervous system. Trends Neurosci 11: 273-277.
19. Shaulian E, Karin M. 2002. AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136.
20. Tikka TM, Koistinaho JE. 2001. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166: 7527-7533.
21. Wang HH, Hsieh HL, Wu CY, Sun CC, Yang CM. 2009. Oxidized low-density lipoprotein induces matrix metalloproteinase-9 expression via a p42/p44 and JNK-dependent AP-1 pathway in brain astrocytes. Glia 57: 24-38.
22. Wang MJ, Kuo JS, Lee WW, Huang HY, Chen WF, Lin SZ. 2006. Translational event mediates differential production of tumor necrosis factor-alpha in hyaluronan-stimulated microglia and macrophages. J Neurochem 97: 857-871.
23. Wang MJ, Lin WW, Chen HL et al. 2002. Silymarin protects dopaminergic neurons against lipopolysaccharide-induced neurotoxicity by inhibiting microglia activation. Eur J Neurosci 16: 2103-2112.
24. Watters JJ, Sommer JA, Pfeiffer ZA, Prabhu U, Guerra AN, Bertics PJ. 2002. A differential role for the mitogen-activated protein kinases in lipopolysaccharide signaling: the MEK/ERK pathway is not essential for nitric oxide and interleukin 1β production. J Biol Chem 277: 9077-9087.
25. Yoon YD, Kang JS, Han SB et al. 2004. Activation of mitogen-activated protein kinases and AP-1 by polysaccharide isolated from the radix of Platycodon grandiflorum in RAW 264.7 cells. Int Immunopharmacol 4: 1477-1487.
26. Yu XQ, Xue CC, Zhou ZW et al. 2008. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci 82: 68-78.
27. Zhou S, Koh HL, Gao Y, Gong ZY, Lee EJ. 2004. Herbal bioactivation: the good, the bad and the ugly. Life Sci 74: 935-968.