Inhibition of nuclear factor-kappa b sensitises anterior pituitary cells to tumour necrosis factor-α- and lipopolysaccharide-induced apoptosis

Journal of Neuroendocrinology

Volumn 23, Issue 8, 2011, Pages 651-659

  Eijo, G ^a   Zarate S ^a   Jaita, G ^a   Ferraris, J ^a   Magri, M L ^a   Zaldivar, V ^a   Radl, D ^a   Boti, V ^a   Pisera, D ^a   Seilicovich, A ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Lactotroph; LPS; NF B; Oestrogens; Pituitary; Somatotroph; TNF

Indexed keywords

3 (4 METHYLPHENYLSULFONYL) 2 PROPENENITRILE; ESTRADIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PROTEIN BCL XL; TUMOR NECROSIS FACTOR ALPHA;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL SELECTION; ENZYME INHIBITION; FEMALE; FLOW CYTOMETRY; FLUORESCENCE; GROWTH HORMONE SECRETING CELL; HYPOPHYSIS CELL; IN VIVO STUDY; NICK END LABELING; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROLACTIN SECRETING CELL; PROTEIN EXPRESSION; RAT; SENSITIZATION; WESTERN BLOTTING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; APOPTOSIS; CELLS, CULTURED; ESTRADIOL; FEMALE; LIPOPOLYSACCHARIDES; NF-KAPPA B; NITRILES; OVARIECTOMY; PITUITARY GLAND, ANTERIOR; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SULFONES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960224619     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2011.02157.x     Document Type: Article

References (44)

1. Schütze S, Tchikov V, Schneider-Brachert W. Regulation of TNFR1 and CD95 signalling by receptor compartmentalization. Nat Rev Mol Cell Biol 2008; 9: 655-662.
2. Lia X, Starkb GR. NFkappaB-dependent signaling pathways. Exp Hematol 2002; 30: 285-296.
3. Hoareau L, Bencharif K, Rondeau P, Murumalla R, Ravanan P, Tallet F, Delarue P, Cesari M, Roche R, Festy F. Signaling pathways involved in LPS induced TNFalpha production in human adipocytes. J Inflamm 2010; 7: 1.
4. Takeda K, Akira S. TLR signaling pathways. Semin Immunol 2004; 16: 3-9.
5. Papa S, Bubici C, Zazzeroni F, Franzoso G. Mechanisms of liver disease: cross-talk between the NF-kappaB and JNK pathways. Biol Chem 2009; 390: 965-976.
6. Dutta J, Fan Y, Gupta N, Fan G, Gélinas C. Current insights into the regulation of programmed cell death by NF-kappaB. Oncogene 2006; 25: 6800-6816.
7. Kalaitzidis D, Gilmore TD. Transcription factor cross-talk: the estrogen receptor and NF-kappaB. Trends Endocrinol Metab 2005; 16: 46-52.
8. Senftleben U, Karin M. The IKK/NF-kappaB pathway. Crit Care Med 2002; 30: S18-S26.
9. Biswas DK, Singh S, Shi Q, Pardee AB, Iglehart JD. Crossroads of estrogen receptor and NF-kappaB signaling. Sci STKE 2005; 2005: pe27.
10. Sarkar DK. Genesis of prolactinomas: studies using estrogen-treated animals. Front Horm Res 2006; 35: 32-49.
11. Ben-Jonathan N, LaPensee CR, LaPensee EW. What can we learn from rodents about prolactin in humans? Endocr Rev 2008; 29: 1-41.
12. Ishida M, Takahashi W, Itoh S, Shimodaira S, Maeda S, Arita J. Estrogen actions on lactotroph proliferation are independent of a paracrine interaction with other pituitary cell types: a study using lactotroph-enriched cells. Endocrinology 2007; 148: 3131-3139.
13. Gutiérrez S, De Paul AL, Petiti JP, del Valle Sosa L, Palmeri CM, Soaje M, Orgnero EM, Torres AI. Estradiol interacts with insulin through membrane receptors to induce an antimitogenic effect on lactotroph cells. Steroids 2008; 73: 515-527.
14. Zaldivar V, Magri ML, Zárate S, Jaita G, Eijo G, Radl D, Ferraris J, Pisera D, Seilicovich A. Oestradiol increases the Bax/Bcl-2 ratio and induces apoptosis in anterior pituitary cells. Neuroendocrinology 2009; 90: 292-300.
15. Zárate S, Jaita G, Zaldivar V, Radl D, Eijo G, Ferraris J, Pisera D, Seilicovich A. Estrogens exert a rapid apoptotic action in anterior pituitary cells. Am J Physiol Endocrinol Metab 2009; 296: E664-E671.
16. Seilicovich A. Cell life and death in the anterior pituitary gland: role of oestrogens. J Neuroendocrinol 2010; 22: 758-764.
17. Pisera D, Candolfi M, Navarra S, Ferraris J, Zaldivar V, Jaita G, Castro MG, Seilicovich A. Estrogens sensitize anterior pituitary gland to apoptosis. Am J Physiol Endocrinol Metab 2004; 287: 767-771.
18. Candolfi M, Zaldivar V, De Laurentiis A, Jaita G, Pisera D, Seilicovich A. TNF-alpha induces apoptosis of lactotropes from female rats. Endocrinology 2002; 143: 3611-3617.
19. Friedrichsen S, Harper CV, Semprini S, Wilding M, Adamson AD, Spiller DG, Nelson G, Mullins JJ, White MR, Davis JR. Tumor necrosis factor-alpha activates the human prolactin gene promoter via nuclear factor-kappaB signaling. Endocrinology 2006; 147: 773-781.
20. Lasa M, Gil-Araujo B, Palafox M, Aranda A. Thyroid hormone antagonizes tumor necrosis factor-alpha signaling in pituitary cells through the induction of dual specificity phosphatase 1. Mol Endocrinol 2010; 24: 412-422.
21. Lewis-Wambi JS, Jordan VC. Estrogen regulation of apoptosis: how can one hormone stimulate and inhibit? Breast Cancer Res 2009; 11: 206.
22. Hsu SM, Chen YC, Jiang MC. 17 beta-estradiol inhibits tumor necrosis factor-alpha-induced nuclear factor-kappa B activation by increasing nuclear factor-kappa B p105 level in MCF-7 breast cancer cells. Biochem Biophys Res Commun 2000; 279: 47-52.
23. Stice JP, Knowlton AA. Estrogen, NFkappaB, and the heat shock response. Mol Med 2008; 14: 517-527.
24. Candolfi M, Jaita G, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG, Seilicovich A. Progesterone antagonizes the permissive action of estradiol on tumor necrosis factor-alpha-induced apoptosis of anterior pituitary cells. Endocrinology 2005; 146: 736-743.
25. Quaedackers ME, van den Brink CE, van der Saag PT, Tertoolen LG. Direct interaction between estrogen receptor alpha and NF-kappaB in the nucleus of living cells. Mol Cell Endocrinol 2007; 273: 42-50.
26. Ghisletti S, Meda C, Maggi A, Vegeto E. 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol 2005; 25: 2957-2968.
27. Vender JR, Laird MD, Dhandapani KM. Inhibition of NFkappaB reduces cellular viability in GH3 pituitary adenoma cells. Neurosurgery 2008; 62: 1122-1127.
28. Taguchi T, Takao T, Iwasaki Y, Nishiyama M, Asaba K, Hashimoto K. Suppressive effects of dehydroepiandrosterone and the nuclear factor-kappaB inhibitor parthenolide on corticotroph tumor cell growth and function in vitro and in vivo. J Endocrinol 2006; 188: 321-331.
29. Bangaru ML, Woodliff J, Raff H, Kansra S. Growth suppression of mouse pituitary corticotroph tumor AtT20 cells by curcumin: a model for treating Cushing's disease. PLoS ONE 2010; 5: e9893.
30. Schaaf C, Shan B, Buchfelder M, Losa M, Kreutzer J, Rachinger W, Stalla GK, Schilling T, Arzt E, Perone MJ, Renner U. Curcumin acts as anti-tumorigenic and hormone-suppressive agent in murine and human pituitary tumour cells in vitro and in vivo. Endocr Relat Cancer 2009; 16: 1339-1350.
31. Gasparian AV, Guryanova OA, Chebotaev DV, Shishkin AA, Yemelyanov AY, Budunova IV. Targeting transcription factor NFkappaB: comparative analysis of proteasome and IKK inhibitors. Cell Cycle 2009; 8: 1559-1566.
32. Rivas MA, Carnevale RP, Proietti CJ, Rosemblit C, Beguelin W, Salatino M, Charreau EH, Frahm I, Sapia S, Brouckaert P, Elizalde PV, Schillaci R. TNF alpha acting on TNFR1 promotes breast cancer growth via p42/P44 MAPK, JNK, Akt and NF-kappa B-dependent pathways. Exp Cell Res 2008; 314: 509-529.
33. García MG, Alaniz L, Lopes EC, Blanco G, Hajos SE, Alvarez E. Inhibition of NF-kappaB activity by BAY 11-7082 increases apoptosis in multidrug resistant leukemic T-cell lines. Leuk Res 2005; 29: 1425-1434.
34. Scaife CL, Kuang J, Wills JC, Trowbridge DB, Gray P, Manning BM, Eichwald EJ, Daynes RA, Kuwada SK. Nuclear factor kappaB inhibitors induce adhesion-dependent colon cancer apoptosis: implications for metastasis. Cancer Res 2002; 62: 6870-6878.
35. Shishodia S, Amin HM, Lai R, Aggarwal BB. Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma. Biochem Pharmacol 2005; 70: 700-713.
36. Werner AB, de Vries E, Tait SW, Bontjer I, Borst J. Bcl-2 family member Bfl-1/A1 sequesters truncated bid to inhibit its collaboration with pro-apoptotic Bak or Bax. J Biol Chem 2002; 277: 22781-22788.
37. Candolfi M, Zaldivar V, Jaita G, Seilicovich A. Anterior pituitary cell renewal during the estrous cycle. Front Horm Res 2006; 35: 9-21.
38. Childs GV. Gonadotropes and Lactotropes. In: Neill JD, ed. Physiology of Reproduction. Amsterdam: Elsevier, 2006: 1483-1580.
39. Kurz SG, Hansen KK, McLaughlin MT, Shivaswamy V, Schaffer BS, Gould KA, McComb RD, Meza JL, Shull JD. Tissue-specific actions of the Ept1, Ept2, Ept6, and Ept9 genetic determinants of responsiveness to estrogens in the female rat. Endocrinology 2008; 149: 3850-3859.
40. Nolan LA, Levy A. Prolonged oestrogen treatment does not correlate with a sustained increase in anterior pituitary mitotic index in ovariectomized Wistar rats. J Endocrinol 2009; 200: 301-309.
41. Melmed S. Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 2003; 112: 1603-1618.
42. Jaita G, Candolfi M, Zaldivar V, Zárate S, Ferrari L, Pisera D, Castro MG, Seilicovich A. Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes. Endocrinology 2005; 146: 4737-4744.
43. Radl DB, Zárate S, Jaita G, Ferraris J, Zaldivar V, Eijo G, Seilicovich A, Pisera D. Apoptosis of lactotrophs induced by D2 receptor activation is estrogen dependent. Neuroendocrinology 2008; 88: 43-52.
44. Zaldivar V, Magri ML, Zárate S, Jaita G, Eijo G, Radl D, Ferraris J, Pisera D, Seilicovich A. Oestradiol increases the expression of TNF-α and TNF Receptor 1 in lactotropes. Neuroendocrinology 2011; 93: 106-113.