Apoptosis of lactotrophs induced by D2 receptor activation is estrogen dependent

Neuroendocrinology

Volumn 88, Issue 1, 2008, Pages 43-52

  Radl, Daniela B ^a   Zárate, Sandra ^a   Jaita, Gabriela ^a   Ferraris, Jimena ^a   Zaldivar, Verónica ^a   Eijo, Guadalupe ^a   Seilicovich, Adriana ^a   Pisera, Daniel ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Anterior pituitary; Apoptosis; D2 receptor; Dopamine; Estradiol; Lactotroph

Indexed keywords

CABERGOLINE; DOPAMINE; DOPAMINE 2 RECEPTOR; DOPAMINE TRANSPORTER; ESTRADIOL; LIPOCORTIN 5; OXIDOPAMINE; SULPIRIDE; VANOXERINE;

ADENOHYPOPHYSIS; ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; BIOASSAY; CELL DEATH; CELL VIABILITY; DRUG MECHANISM; FEMALE; FLOW CYTOMETRY; IMMUNOCYTOCHEMISTRY; NICK END LABELING; NONHUMAN; OVARIECTOMY; PRIORITY JOURNAL; PROLACTIN SECRETING CELL; RAT; RECEPTOR UPREGULATION;

ANIMALS; APOPTOSIS; CELL COUNT; CELLS, CULTURED; DOPAMINE; ESTROGENS; FEMALE; LACTOTROPHS; RATS; RATS, WISTAR; RECEPTORS, DOPAMINE D2;

EID: 47549101444     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000116117     Document Type: Article

References (41)

1. Ben-Jonathan N, Hnasko R: Dopamine as a prolactin (PRL) inhibitor. Endocr Rev 2001;22:724-763.
2. Missale C, Russel Nash S, Robinson S, Jaber M, Caron M: Dopamine receptors: from structure to function. Physiol Rev 1998;78:189-225.
3. Storch A, Ludolph AC, Schwarz J: Dopamine transporter: involvement in selective dopaminergic neurotoxicity and degeneration. J Neural Transm 2004;111:1267-1286.
4. Junn E, Mouradian MM: Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. J Neurochem 2001;78:374-383.
5. Shinkai T, Zhang L, Mathias SA, Roth GS: Dopamine induces apoptosis in cultured rat striatal neurons; possible mechanism of D2-dopamine receptor neuron loss during aging. J Neurosci Res 1997;47:393-399.
6. Offen D, Ziv I, Gorodin S, Barzilai A, Malik Z, Melamed E: Dopamine-induced programmed cell death in mouse thymocytes. Biochem Biophys Acta 1995;1268:171-177.
7. Chen J, Wersinger C, Sidhu A: Chronic stimulation of D1 dopamine receptors in human SK-N-MC neuroblastome cells induces nitric-oxide synthase activation and cytotoxicity. J Biol Chem 2003;278:28089-28100.
8. Charvin D, Vanhoutte P, Pagès C, Borrelli E, Caboche J: Unraveling a role for dopamine in Huntington's disease: the dual role of reactive oxygen species and D2 receptor stimulation. Proc Natl Acad Sci 2005;102:12218-12223.
9. Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM: Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 2001;65:135-172.
10. Hanrott K, Gudmunsen L, O'Neill MJ, Wonnacott S:6-Hydroxydopamine-induced apoptosis is mediated by extracellular autooxidation and caspase 3-independent activation of protein kinase Cδ. J Biol Chem 2006;281:5373-5382.
11. Woodgate A, MacGibbon G, Walton M, Dragunow M: The toxicity of 6-hydroxydopamine on PC12 and P19 cells. Mol Brain Res 1999;69:84-92.
12. Sarkar DK, Chaturvedi K, Oomizu S, Boyadjieva NI, Chen CP: Dopamine, dopamine D2 receptor short isoform, transforming growth factor (TGF)-β1, and TGF-β type II receptor interact to inhibit the growth of pituitary lactotropes. Endocrinology 2005;146:4179-4188.
13. An JJ, Cho SR, Jeong DW, Park KW, Ahn YS, Baik JH: Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells. Mol Cell Endocrinol 2003;206:49-62.
14. Jaubert A, Ichas F, Bresson Bepoldin L: Signaling pathway involved in the pro-apoptotic effect of dopamine in GH3 pituitary cell line. Neuroendocrinology 2006;83:77-88.
15. Jaubert A, Drutel G, Leste-Lasserre T, Ichas F, Bresson Bepoldin L: TH and DAT expression in lactotrophs from post-lactating rats: involvement in DA-induced apoptosis. Endocrinology 2007;148:2698-2707.
16. Mitsuma T, Rhue N, Hirooka Y, Kayama M, Wago T, Mori Y, Takagi J, Adachi IK, Ping J, Ohtake M, Nogimori T, Sakai J: Distribution of dopamine transporter in the rat: an immunohistochemical study. Endocr Regul 1998;32:71-75.
17. Hashi A, Mazawa S, Chen S, Kato J, Arita J: Pentobarbital anesthesia during the proestrous afternoon blocks lactotroph proliferation occurring on estrus in female rats. Endocrinology 1995;136:4665-4671.
18. Yin P, Arita J: Proestrus surge of gonadotropin-releasing hormone secretion inhibits apoptosis of anterior pituitary cells in cycling female rats. Neuroendocrinology 2002;76:272-282.
19. Candolfi M, Jaita G, Zaldivar V, Zarate S, Pisera D, Seilicovich A: Tumor necrosis factor-alpha-induced nitric oxide restrains the apoptotic response of anterior pituitary cells. Neuroendocrinology 2004;80:83-91.
20. Jaita G, Candolfi M, Zaldivar V, Zarate S, Ferrari L, Pisera D, Castro MG, Seilicovich A: Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotrophs. Endocrinology 2005;146:4737-4744.
21. Pisera D, Candolfi M, Navarra S, Ferraris J, Zaldivar V, Jaita G, Castro MG, Seilicovich A: Estrogens sensitize anterior pituitary gland to apoptosis. Am J Physiol Endocrinol Metab 2004;287:767-771.
22. Candolfi M, Zaldivar V, Jaita G, Seilicovich A: Anterior pituitary cell renewal during the estrous cycle. Front Horm Res 2006;35:9-21.
23. Close FT, Freeman ME: Effects of ovarian steroid hormones on dopamine-controlled prolactin secretory responses in vitro. Neuroendocrinology 1997;65:430-435.
24. Freeman ME, Kanyicska B, Lerant A, Nagy G: Prolactin: structure, function, and regulation of secretion. Physiol Rev 2000;80:1523-1631.
25. Kawashima K, Yamakawa K, Takahashi W, Takizawa S, Yin P, Sugiyama N, Kanba S, Arita J: The estrogen-occupied estrogen receptor functions as a negative regulator to inhibit cell proliferation induced by insulin/IGF-1: a cell context-specific antimitogenic action of estradiol on rat lactotrophs in culture. Endocrinology 2002;143:2750-2758.
26. Gutiérrez S, Petiti JP, De Paul AL, Mukdsi JH, Aoki A, Torres AI, Orgnero EM: Antagonic effects of oestradiol in interaction with IGF-1 on proliferation of lactotroph cells in vitro. Histochem Cell Biol 2005;124:291-301.
27. Oomizu S, Chaturvedi K, Sarkar DK: Folliculostellate cells determine the susceptibility of lactotropes to estradiol's mitogenic action. Endocrinology 2004;145:1473-1480.
28. Gillam M, Molitch M, Lombardi G, Colao A: Advances in the treatment of prolactinomas. Endocr Rev 2006;27:485-534.
29. Oomizu S, Boyadjieva N, Sarkar D: Ethanol and estradiol modulate alternative splicing of dopamine D2 receptor messenger RNA and abolish the inhibitory action of bromocriptine on prolactin release from the pituitary gland. Alcohol Clin Exp Res 2003;27:975-980.
30. Guivarc'h D, Vincent JD, Vernier P: Alternative splicing of D2 dopamine receptor messenger ribonucleic acid is modulated by activated sex steroid receptors in the MMQ prolactin cell line. Endocrinology 1998;139:4213-4221.
31. Pivonello R, Ferone D, de Herder WW, Kros JM, De Caro ML, Arvigo M, Annunziato L, Lombardi G, Colao A, Hofland LJ, Lamberts SW: Dopamine receptor expression and function in corticotroph pituitary tumors. J Clin Endocrinol Metab 2004;89:2452-2462.
32. Pellegrini-Bouiller I, Morange-Ramos I, Barlier A, Gunz G, Figarella-Branger D, Cortet-Rudelli C, Grisoli F, Jaquet P, Enjalbert A: Pit-1 gene expression in human lactotroph and somatotroph pituitary adenomas is correlated to D2 receptor gene expression. J Clin Endocrinol Metab 1996;81:3390-3396.
33. Mutiara S, Kanasaki H, Harada T, Miyazaki K: Dopamine D(2) receptor expression and regulation of gonadotropin alpha-subunit gene in clonal gonadotroph LbetaT2 cells. Mol Cell Endocrinol 2006;259:22-29.
34. Bossé R, Fumagalli F, Jaber M, Giros B, Gainetdinov RR, Wetsel WC, Missale C, Caron MG: Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron 1997;19:127-138.
35. Kelly MA, Rubinstein M, Asa SL, Zhang G, Saez C, Bunzow JR, Allen RG, Hnasko R, Ben-Jonathan N, Grandy DK, Low MJ: Pituitary lactotroph hyperplasia and chronic hyperprolactinemia in dopamine D2 receptor-deficient mice. Neuron 1997;19:103-113.
36. Saiardi A, Bozzi Y, Baik JH, Borrelli E: Antiproliferative role of dopamine: loss of D2 receptor cause hormonal dysfunction and pituitary hyperplasia. Neuron 1997;19:115-126.
37. Kulig E, Jin L, Qian X, Horvath E, Kovacs K, Stefaneanu L, Scheithauer BW, Lloyd RV: Apoptosis in nontumorous and neoplastic human pituitaries: expression of the Bcl-2 family of proteins. Am J Pathol 1999;154:767-774.
38. Manakova S, Puttonen KA, Raasmaja A, Mannisto PT: The roles of dopamine transporter and Bcl-2 protein in the protection of CV1-P cells from 6-OHDA-induced toxicity. Toxicol Lett 2004;154:117-123.
39. Redman PT, Jefferson BS, Ziegler CB, Mortensen OV, Torres GE, Levitan ES, Aizenman E: A vital role for voltage-dependent potassium channels in dopamine transporter-mediated 6-hydroxydopamine neurotoxicity. Neuroscience 2006;143:1-6.
40. Dluzen DE: Unconventional effects of estrogen uncovered. Trends Pharmacol Sci 2005;29:485-487.
41. Watson CS, Alyea RA, Hawkins BE, Thomas ML, Cunningham KA, Jakubas AA: Estradiol effects on the dopamine transporterprotein levels, subcellular location, and function. J Mol Signal 2006;1:5-18.