Synthesis and antimalarial activity of 2-guanidino-4-oxoimidazoline derivatives

Journal of Medicinal Chemistry

Volumn 54, Issue 13, 2011, Pages 4523-4535

  Liu, Xianjun ^a   Wang, Xihong ^a   Li, Qigui ^a   Kozar, Michael P ^a   Melendez, Victor ^a   O Neil, Michael T ^a   Lin, Ai J ^a  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 GUANIDINO 4 OXOIMIDAZOLINE DERIVATIVE; 8 AMINOQUINOLINE; ANTIMALARIAL AGENT; DRUG METABOLITE; N (2 ETHYLBUTYRYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL) N'' (TRIMETHYLACETYL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 METHYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' (1 TERT BUTYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (3,4 DICHLOROPHENYL) N' ISOPROPYL N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (ADAMANTYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (ETHOXYCARBONYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (ETHOXYCARBONYL) N' [1 (3,4 DICHLOROPHENYL) 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N'' ISOPROPYLGUANIDINE; N (ETHYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (ISOPROPYL) N' (3,4 DICHLOROPHENYL) N'' (1 METHYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (TERT BUTOXYCARBONYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (TERT BUTOXYCARBONYL) N' (3,4 DICHLOROPHENYL) N'' (1 METHYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (TERT BUTOXYCARBONYL) N' (3,4 DICHLOROPHENYL) N'' (1 TERT BUTYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N (TERT BUTOXYCARBONYL) N' [1 (3,4 DICHLOROPHENYL) 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N'' ISOPROPYLGUANIDINE; N (TERT BUTYL) N' (3,4 DICHLOROPHENYL) N'' (1 ISOPROPYL 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL)GUANIDINE; N [1 (3,4 DICHLOROPHENYL) 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N' ISOPROPYLGUANIDINE; N [1 (3,4 DICHLOROPHENYL) 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N'' (2 ETHYLBUTYRYL)GUANIDINE; N [1 (3,4 DICHLOROPHENYL) 4 OXO 4,5 DIHYDRO 1H IMIDAZOL 2 YL] N'' (TRIMETHYLACETYL)GUANIDINE; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; DRUG METABOLISM; DRUG STABILITY; DRUG SYNTHESIS; NONHUMAN; PLASMODIUM CYNOMOLGI; SPOROZOITE; STEREOCHEMISTRY;

ADMINISTRATION, ORAL; ANIMALS; ANTIMALARIALS; GUANIDINES; IMIDAZOLIDINES; IMIDAZOLINES; MACACA MULATTA; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM CYNOMOLGI; PLASMODIUM FALCIPARUM; PRODRUGS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79960192736     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200111g     Document Type: Article

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