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Abbreviations: (S,S)- i -Pr-Foxap = (S,S)-[2-(4′-isopropyloxazolin- 2′-yl)ferrocenyl]diphenylphosphine. See:;, (S,S)-CHIRAPHOS = (2 S,3 S)-bis(diphenylphosphino)butane
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Abbreviations: (S,S)- i -Pr-Foxap = (S,S)-[2-(4′-isopropyloxazolin- 2′-yl)ferrocenyl]diphenylphosphine. See: Miyake, Y.; Nishibayashi, Y.; Uemura, S. Synlett 2008, 1747 (S,S)-CHIRAPHOS = (2 S,3 S)-bis(diphenylphosphino) butane.
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Oxidative cyclization of 1-octene and cyclohexyl isocyanate catalyzed by a nickel(0)/IPr complex forms five-membered ring azanickelacycle, the alkene substituent (a hexyl group) of which is bound to a carbon β to nickel
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Oxidative cyclization of 1-octene and cyclohexyl isocyanate catalyzed by a nickel(0)/IPr complex forms five-membered ring azanickelacycle, the alkene substituent (a hexyl group) of which is bound to a carbon β to nickel. Schleicher, K. D.; Jamison, T. F. Org. Lett. 2007, 9, 875
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eq = 1)
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eq = 1). Louie, J.; Gibby, J. E.; Farnworth, M. V.; Tekavec, T. N. J. Am. Chem. Soc. 2002, 124, 15188
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For an example of NHC acting as a base, see
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For an example of NHC acting as a base, see: Phillips, E. M.; Riedrich, M.; Scheidt, K. A. J. Am. Chem. Soc. 2010, 132, 13179
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11444262868
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Another mechanism consisting of intermolecular addition of NHC to isocyanate followed by conjugate addition of the resulting nitrogen anion to 4 and subsequent ring closure is also conceivable. For intermolecular addition of NHC to isocyanate, see
-
Another mechanism consisting of intermolecular addition of NHC to isocyanate followed by conjugate addition of the resulting nitrogen anion to 4 and subsequent ring closure is also conceivable. For intermolecular addition of NHC to isocyanate, see: Duong, H. A.; Cross, M. J.; Louie, J. Org. Lett. 2004, 6, 4679
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N -Substituted fumaramates can be also prepared by half-esterification of fumaric acid with alcohols, followed by amidation with aniline derivatives. See the Supporting Information for details
-
N -Substituted fumaramates can be also prepared by half-esterification of fumaric acid with alcohols, followed by amidation with aniline derivatives. See the Supporting Information for details.
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