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Volumn 6, Issue 4, 2011, Pages 497-499

Phosphodiesterases: Genes and their variants, inhibitors and potential therapeutic applications

Author keywords

endocrine tumors; PDE; PDE inhibitors; phosphodiesterase; secondary messengers

Indexed keywords

ALDOSTERONE; CYCLIC AMP; CYCLIC GMP; CYCLIC GMP DEPENDENT PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NITRIC OXIDE SYNTHASE; PHOSPHODIESTERASE; PHOSPHODIESTERASE 10A; PHOSPHODIESTERASE 11A; PHOSPHODIESTERASE 2A; PHOSPHODIESTERASE 4B; PHOSPHODIESTERASE 5A; PHOSPHODIESTERASE V INHIBITOR; PHOSPHODIESTERASE VI; PROTEIN P53; RAF PROTEIN; UNCLASSIFIED DRUG;

EID: 79960166725     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/eem.11.48     Document Type: Editorial
Times cited : (2)

References (33)
  • 1
    • 60249089353 scopus 로고    scopus 로고
    • ABCD of the phosphodiesterase family: Interaction and differential activity in COPD
    • Halpin DM. ABCD of the phosphodiesterase family: interaction and differential activity in COPD. Int. J. Chron. Obstruct. Pulmon. Dis. 3(4), 543-561 (2008).
    • (2008) Int. J. Chron. Obstruct. Pulmon. Dis , vol.3 , Issue.4 , pp. 543-561
    • Halpin, D.M.1
  • 2
    • 34447265905 scopus 로고    scopus 로고
    • Biochemistry and physiology of cyclic nucleotide phosphodiesterases: Essential components in cyclic nucleotide signaling
    • Conti M, Beavo J. Biochemistry and physiology of cyclic nucleotide phosphodiesterases: essential components in cyclic nucleotide signaling. Annu. Rev. Biochem. 76, 481-511 (2007).
    • (2007) Annu. Rev. Biochem , vol.76 , pp. 481-511
    • Conti, M.1    Beavo, J.2
  • 3
    • 12544251544 scopus 로고    scopus 로고
    • Real-time monitoring of the PDE2 activity of live cells: Hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis
    • Nikolaev VO, Gambaryan S, Engelhardt S, Walter U, Lohse MJ. Real-time monitoring of the PDE2 activity of live cells: hormone-stimulated cAMP hydrolysis is faster than hormone-stimulated cAMP synthesis. J. Biol. Chem. 280(3), 1716-1719 (2005).
    • (2005) J. Biol. Chem , vol.280 , Issue.3 , pp. 1716-1719
    • Nikolaev, V.O.1    Gambaryan, S.2    Engelhardt, S.3    Walter, U.4    Lohse, M.J.5
  • 4
    • 42749089914 scopus 로고    scopus 로고
    • PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia
    • Fatemi SH, King DP, Reutiman TJ, et al. PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia. Schizophr. Res. 101(1-3), 36-49 (2008).
    • (2008) Schizophr. Res , vol.101 , Issue.1-3 , pp. 36-49
    • Fatemi, S.H.1    King, D.P.2    Reutiman, T.J.3
  • 5
    • 0028789921 scopus 로고
    • Autosomal recessive retinitis pigmentosa caused by mutations in the a subunit of rod cGMP phosphodiesterase
    • Huang SH, Pittler SJ, Huang X, Oliveira L, Berson EL, Dryja TP. Autosomal recessive retinitis pigmentosa caused by mutations in the a subunit of rod cGMP phosphodiesterase. Nat. Genet. 11(4), 468-471 (1995).
    • (1995) Nat. Genet , vol.11 , Issue.4 , pp. 468-471
    • Huang, S.H.1    Pittler, S.J.2    Huang, X.3    Oliveira, L.4    Berson, E.L.5    Dryja, T.P.6
  • 6
    • 70449713420 scopus 로고    scopus 로고
    • Association of PDE11A global haplotype with major depression and antidepressant drug response
    • Luo HR, Wu GS, Dong C, et al. Association of PDE11A global haplotype with major depression and antidepressant drug response. Neuropsychiatr. Dis. Treat. 5, 163-170 (2009).
    • (2009) Neuropsychiatr. Dis. Treat , vol.5 , pp. 163-170
    • Luo, H.R.1    Wu, G.S.2    Dong, C.3
  • 9
    • 67650505040 scopus 로고    scopus 로고
    • Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors
    • Horvath A, Korde L, Greene MH, et al. Functional phosphodiesterase 11A mutations may modify the risk of familial and bilateral testicular germ cell tumors. Cancer Res. 69(13), 5301-5306 (2009).
    • (2009) Cancer Res , vol.69 , Issue.13 , pp. 5301-5306
    • Horvath, A.1    Korde, L.2    Greene, M.H.3
  • 10
    • 78650868311 scopus 로고    scopus 로고
    • Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer
    • Faucz FR, Horvath A, Rothenbuhler A, et al. Phosphodiesterase 11A (PDE11A) genetic variants may increase susceptibility to prostatic cancer. J. Clin. Endocrinol. Metab. 96(1), E135-E140 (2011).
    • (2011) J. Clin. Endocrinol. Metab , vol.96 , Issue.1
    • Faucz, F.R.1    Horvath, A.2    Rothenbuhler, A.3
  • 12
    • 62449195496 scopus 로고    scopus 로고
    • Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation
    • Threlfell S, Sammut S, Menniti FS, Schmidt CJ, West AR. Inhibition of phosphodiesterase 10A increases the responsiveness of striatal projection neurons to cortical stimulation. J. Pharmacol. Exp. Ther. 328(3), 785-795 (2009).
    • (2009) J. Pharmacol. Exp. Ther , vol.328 , Issue.3 , pp. 785-795
    • Threlfell, S.1    Sammut, S.2    Menniti, F.S.3    Schmidt, C.J.4    West, A.R.5
  • 13
    • 69049103114 scopus 로고    scopus 로고
    • Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol- 3-yl)-phenoxymethyl]-quinoline (PF- 2545920) for the treatment of schizophrenia
    • Verhoest PR, Chapin DS, Corman M, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol- 3-yl)-phenoxymethyl]-quinoline (PF- 2545920) for the treatment of schizophrenia. J. Med. Chem. 52(16), 5188-5196 (2009).
    • (2009) J. Med. Chem , vol.52 , Issue.16 , pp. 5188-5196
    • Verhoest, P.R.1    Chapin, D.S.2    Corman, M.3
  • 16
    • 33750846632 scopus 로고    scopus 로고
    • Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms [5]
    • DOI 10.1111/j.1464-410X.2006.06628-5.x
    • Hotston M, Shukla N, Bloor J, Persad R, Jeremy JY. Pre-clinical evidence for the use of phosphodiesterase-5 inhibitors for treating benign prostatic hyperplasia and lower urinary tract symptoms. BJU Int. 98(6), 1331-1332 (2006). (Pubitemid 44721256)
    • (2006) BJU International , vol.98 , Issue.6 , pp. 1331-1332
    • Hotston, M.1    Shukla, N.2    Bloor, J.3    Persad, R.4    Jeremy, J.Y.5
  • 17
    • 74549146102 scopus 로고    scopus 로고
    • Phosphodiesterase-5 inhibitors and benign prostatic hyperplasia
    • Wang C. Phosphodiesterase-5 inhibitors and benign prostatic hyperplasia. Curr. Opin. Urol. 20(1), 49-54 (2010).
    • (2010) Curr. Opin. Urol , vol.20 , Issue.1 , pp. 49-54
    • Wang, C.1
  • 18
    • 58149267874 scopus 로고    scopus 로고
    • Phosphodiesterase 5 inhibitors in the management of benign prostatic hyperplasia and erectile dysfunction: The best of both worlds
    • Wong P, Lawrentschuk N, Bolton DM. Phosphodiesterase 5 inhibitors in the management of benign prostatic hyperplasia and erectile dysfunction: the best of both worlds. Curr. Opin. Urol. 19(1), 7-12 (2009).
    • (2009) Curr. Opin. Urol , vol.19 , Issue.1 , pp. 7-12
    • Wong, P.1    Lawrentschuk, N.2    Bolton, D.M.3
  • 19
    • 18444366205 scopus 로고    scopus 로고
    • Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells
    • DOI 10.1002/jcb.20286
    • Zhu B, Vemavarapu L, Thompson WJ, Strada SJ. Suppression of cyclic GMP-specific phosphodiesterase 5 promotes apoptosis and inhibits growth in HT29 cells. J. Cell. Biochem. 94(2), 336-350 (2005). (Pubitemid 41420312)
    • (2005) Journal of Cellular Biochemistry , vol.94 , Issue.2 , pp. 336-350
    • Zhu, B.1    Vemavarapu, L.2    Thompson, W.J.3    Strada, S.J.4
  • 20
    • 73149104650 scopus 로고    scopus 로고
    • Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G
    • Tinsley HN, Gary BD, Keeton AB, et al. Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G. Mol. Cancer Ther. 8(12), 3331-3340 (2009).
    • (2009) Mol. Cancer Ther , vol.8 , Issue.12 , pp. 3331-3340
    • Tinsley, H.N.1    Gary, B.D.2    Keeton, A.B.3
  • 21
    • 0344014113 scopus 로고    scopus 로고
    • Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells
    • DOI 10.1016/S0898-6568(03)00134-7
    • Cook AL, Haynes JM. Protein kinase G II-mediated proliferative effects in human cultured prostatic stromal cells. Cell Signal 16(2), 253-261 (2004). (Pubitemid 37441272)
    • (2004) Cellular Signalling , vol.16 , Issue.2 , pp. 253-261
    • Cook, A.-L.M.1    Haynes, J.M.2
  • 22
    • 0032483514 scopus 로고    scopus 로고
    • Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells
    • DOI 10.1074/jbc.273.36.23504
    • Hood J, Granger HJ. Protein kinase G mediates vascular endothelial growth factor-induced Raf-1 activation and proliferation in human endothelial cells. J. Biol. Chem. 273(36), 23504-23508 (1998). (Pubitemid 28417542)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.36 , pp. 23504-23508
    • Hood, J.1    Granger, H.J.2
  • 24
    • 0028902552 scopus 로고
    • Nitric oxide synthases: Properties and catalytic mechanism
    • Griffith OW, Stuehr DJ. Nitric oxide synthases: properties and catalytic mechanism. Annu. Rev. Physiol. 57, 707-736 (1995).
    • (1995) Annu. Rev. Physiol , vol.57 , pp. 707-736
    • Griffith, O.W.1    Stuehr, D.J.2
  • 26
    • 0027986509 scopus 로고
    • Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP
    • Cornwell TL, Arnold E, Boerth NJ, Lincoln TM. Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP. Am. J. Physiol. 267(5 Pt 1), C1405-C1413 (1994).
    • (1994) Am. J. Physiol , vol.267 , Issue.5 PART 1
    • Cornwell, T.L.1    Arnold, E.2    Boerth, N.J.3    Lincoln, T.M.4
  • 28
    • 35148897384 scopus 로고    scopus 로고
    • N-terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization
    • DOI 10.1021/bi7009629
    • Weeks JL 2nd, Zoraghi R, Francis SH, Corbin JD. N-Terminal domain of phosphodiesterase-11A4 (PDE11A4) decreases affinity of the catalytic site for substrates and tadalafil, and is involved in oligomerization. Biochemistry 46(36), 10353-10364 (2007). (Pubitemid 350067628)
    • (2007) Biochemistry , vol.46 , Issue.36 , pp. 10353-10364
    • Weeks II, J.L.1    Zoraghi, R.2    Francis, S.H.3    Corbin, J.D.4
  • 29
    • 70949087930 scopus 로고    scopus 로고
    • Chronic PDE-5 inhibition in patients with erectile dysfunction: New treatment approach using once daily Tadalafil
    • 1318
    • Porst H, Hell-Momeni K, Buttner H. [Chronic PDE-5 inhibition in patients with erectile dysfunction: new treatment approach using once daily Tadalafil]. Urologe A 48(11), 1318, 1320-1319 (2009).
    • (2009) Urologe A , vol.48 , Issue.11 , pp. 1320-1319
    • Porst, H.1    Hell-Momeni, K.2    Buttner, H.3
  • 30
    • 73449117918 scopus 로고    scopus 로고
    • Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A
    • Desiniotis A, Schafer G, Klocker H, Eder IE. Enhanced antiproliferative and proapoptotic effects on prostate cancer cells by simultaneously inhibiting androgen receptor and cAMP-dependent protein kinase A. Int. J. Cancer 126(3), 775-789 (2010).
    • (2010) Int. J. Cancer , vol.126 , Issue.3 , pp. 775-789
    • Desiniotis, A.1    Schafer, G.2    Klocker, H.3    Eder, I.E.4
  • 31
    • 78650413899 scopus 로고    scopus 로고
    • Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor
    • Merkle D, Hoffmann R. Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: cross-talk with the androgen receptor. Cell Signal 23(3), 507-515 (2011).
    • (2011) Cell Signal , vol.23 , Issue.3 , pp. 507-515
    • Merkle, D.1    Hoffmann, R.2
  • 32
    • 33645073402 scopus 로고    scopus 로고
    • Functional interactions of protein kinase A and C in signalling networks: A recapitulation
    • Maioli E, Torricelli C, Fortino V. Functional interactions of protein kinase A and C in signalling networks: a recapitulation. Cell Mol. Life Sci. 63(6), 637-641 (2006).
    • (2006) Cell Mol. Life Sci , vol.63 , Issue.6 , pp. 637-641
    • Maioli, E.1    Torricelli, C.2    Fortino, V.3
  • 33
    • 79953792348 scopus 로고    scopus 로고
    • Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration
    • Yadav V, Denning MF. Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced invasion/migration. Mol. Carcinog. 50(5), 346-352 (2011).
    • (2011) Mol. Carcinog , vol.50 , Issue.5 , pp. 346-352
    • Yadav, V.1    Denning, M.F.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.