Estimation of carboxylic acid metabolite of clopidogrel in Wistar rat plasma by HPLC and its application to a pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 821, Issue 2, 2005, Pages 173-180

  Singh, Sonu S ^a   Sharma, Kuldeep ^a   Barot, Deepak ^a   Mohan, P Ram ^a   Lohray, Vidya B ^a  

^a ZYDUS RESEARCH CENTRE   (India)

Author keywords

Carboxylic acid metabolite of clopidogrel; Rat plasma; Validation and pharmacokinetics

Indexed keywords

CORRELATION METHODS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVING SYSTEMS STUDIES; METABOLITES; METHANE; PHARMACOKINETICS; PLASMAS; SAMPLING;

ATORVASTATIN; CLOPIDOGREL; CORRELATION COEFFICIENT; DI-CHLORO METHANE;

CARBOXYLIC ACIDS;

ACETIC ACID ETHYL ESTER; ACETONITRILE; ATORVASTATIN; CARBOXYLIC ACID; CLOPIDOGREL; DICHLOROMETHANE; DRUG METABOLITE; METHANOL; WATER;

ACCURACY; ANALYTIC METHOD; ANIMAL EXPERIMENT; ARTICLE; BLOOD SAMPLING; CALIBRATION; CHEMICAL COMPOSITION; CHROMATOGRAPHY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION COEFFICIENT; ELUTION; ENVIRONMENTAL TEMPERATURE; EXTRACTION; FREEZE THAWING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRACTICE GUIDELINE; PRIORITY JOURNAL; RAT; STANDARD; VALIDATION PROCESS;

ANIMALS; CARBOXYLIC ACIDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; MALE; RATS; RATS, WISTAR; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TICLOPIDINE;

RATTUS NORVEGICUS;

EID: 20444446420     PISSN: 15700232     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jchromb.2005.05.013     Document Type: Article

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