Weight loss as a cure for Type 2 diabetes: Fact or fantasy?

Expert Review of Endocrinology and Metabolism

Volumn 6, Issue 4, 2011, Pages 557-561

  Kashyap, Sangeeta R ^a   Louis, Emily S ^a,b   Kirwan, John P ^a,b  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cell function; gastric bypass surgery; insulin resistance; lifestyle modification; obesity; Type 2 diabetes; weight loss

Indexed keywords

GLUCAGON LIKE PEPTIDE 1; INCRETIN;

ARTICLE; BODY MASS; CELL FUNCTION; INSULIN RELEASE; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIFESTYLE MODIFICATION; NON INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; STOMACH BYPASS; WEIGHT REDUCTION;

EID: 79960161814     PISSN: 17446651     EISSN: 17448417     Source Type: Journal    
DOI: 10.1586/eem.11.42     Document Type: Article

References (27)

1. Defronzo RA. Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of Type 2 diabetes mellitus. Diabetes 58, 773-795 (2009).
2. Unger RH. Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144, 5159-5165 (2003). (Pubitemid 37476041)
3. Defronzo RA. Pathogenesis of Type 2 diabetes mellitus. Med. Clin. North Am. 88, 787-835, ix (2004).
4. Vollmer K, Holst JJ, Baller B, et al. Predictors of incretin concentrations in subjects with normal, impaired, and diabetic glucose tolerance. Diabetes 57, 678-687 (2008).
5. Pi-Sunyer X, Blackburn G, Brancati FL, et al. Reduction in weight and cardiovascular disease risk factors in individuals with Type 2 diabetes: one-year results of the look AHEAD trial. Diabetes Care 30, 1374-1383 (2007). (Pubitemid 46871141)
6. Klein S, Sheard NF, Pi-Sunyer X, et al. Weight management through lifestyle modification for the prevention and management of Type 2 diabetes: rationale and strategies: a statement of the American Diabetes Association, the North American Association for the Study of Obesity, and the American Society for Clinical Nutrition. Diabetes Care 27, 2067-2073 (2004). (Pubitemid 38989258)
7. Camastra S, Manco M, Mari A, et al. b-cell function in morbidly obese subjects during free living: long-term effects of weight loss. Diabetes 54, 2382-2389 (2005). (Pubitemid 41134266)
8. Polonsky KS, Gumbiner B, Ostrega D, Griver K, Tager H, Henry RR. Alterations in immunoreactive proinsulin and insulin clearance induced by weight loss in NIDDM. Diabetes 43, 871-877 (1994). (Pubitemid 24196418)
9. Pories WJ, Swanson MS, MacDonald KG, et al. Who would have thought it? An operation proves to be the most effective therapy for adult-onset diabetes mellitus. Ann. Surg. 222, 339-350 (1995).
10. Hofso D, Jenssen T, Bollerslev J, et al. b cell function after weight loss: a clinical trial comparing gastric bypass surgery and intensive lifestyle intervention. Eur. J. Endocrinol. 164, 231-238 (2011).
11. le Roux CW, Aylwin SJ, Batterham RL, et al. Gut hormone profiles following bariatric surgery favor an anorectic state, facilitate weight loss, and improve metabolic parameters. Ann. Surg. 243, 108-114 (2006). (Pubitemid 43054062)
12. Mingrone G, DeGaetano A, Greco AV, et al. Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids. Diabetologia 40, 599-605 (1997). (Pubitemid 27186798)
13. Morinigo R, Vidal J, Lacy AM, et al. Circulating peptide YY, weight loss, and glucose homeostasis after gastric bypass surgery in morbidly obese subjects. Ann. Surg. 247, 270-275 (2008). (Pubitemid 351156769)
14. Kashyap SR, Daud S, Kelly KR, et al. Acute effects of gastric bypass versus gastric restrictive surgery on b-cell function and insulinotropic hormones in severely obese patients with Type 2 diabetes. Int. J. Obes. 34(3), 462-471 (2009).
15. Laferrere B, Teixeira J, McGinty J, et al. Effect of weight loss by gastric bypass surgery versus hypocaloric diet on glucose and incretin levels in patients with Type 2 diabetes. J. Clin. Endocrinol. Metab. 93, 2479-2485 (2008). (Pubitemid 352008510)
16. Dixon JB, OBrien PE, Playfair J, et al. Adjustable gastric banding and conventional therapy for Type 2 diabetes: a randomized controlled trial. J. Am. Med. Assoc. 299, 316-323 (2008). (Pubitemid 351159368)
17. Korner J, Bessler M, Inabnet W, Taveras C, Holst JJ. Exaggerated glucagon-like peptide-1 and blunted glucose-dependent insulinotropic peptide secretion are associated with Roux-en-Y gastric bypass but not adjustable gastric banding. Surg. Obes. Relat. Dis. 3, 597-601 (2007). (Pubitemid 350091417)
18. Laferrere B, Heshka S, Wang K, et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with Type 2 diabetes. Diabetes Care 30, 1709-1716 (2007). (Pubitemid 47036341)
19. Goldfine AB, Mun EC, Devine E, et al. Patients with neuroglycopenia after gastric bypass surgery have exaggerated incretin and insulin secretory responses to a mixed meal. J. Clin. Endocrinol. Metab. 92, 4678-4685 (2007). (Pubitemid 350223444)
20. Bogardus C, Ravussin E, Robbins DC, Wolfe RR, Horton ES, Sims EA. Effects of physical training and diet therapy on carbohydrate metabolism in patients with glucose intolerance and non-insulin-dependent diabetes mellitus. Diabetes 33, 311-318 (1984). (Pubitemid 14169529)
21. Dela F, von Linstow ME, Mikines KJ, Galbo H. Physical training may enhance b-cell function in Type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 287, E1024-E1031 (2004). (Pubitemid 39382942)
22. Henry RR, Gumbiner B. Benefits and limitations of very-low-calorie diet therapy in obese NIDDM. Diabetes Care 14, 802-823 (1991).
23. Kelley DE, Wing R, Buonocore C, Sturis J, Polonsky K, Fitzsimmons M. Relative effects of calorie restriction and weight loss in noninsulin-dependent diabetes mellitus. J. Clin. Endocrinol. Metab. 77, 1287-1293 (1993). (Pubitemid 23345484)
24. Kelly KR, Brooks LM, Solomon TP, Kashyap S, OLeary VB, Kirwan JP. The glucose-dependent insulinotropic polypeptide (GIP) and glucose-stimulated insulin response to exercise training and diet in obesity. Am. J. Physiol. Endocrinol. Metab. 2966), E1269-E1274 (2009).
25. Solomon TP, Haus JM, Kelly KR, et al. Randomized trial on the effects of a 7-d low-glycemic diet and exercise intervention on insulin resistance in older obese humans. Am. J. Clin. Nutr. 90, 1222-1229 (2009).
26. Solomon TP, Haus JM, Kelly KR, et al. A low-glycemic index diet combined with exercise reduces insulin resistance, postprandial hyperinsulinemia, and glucose-dependent insulinotropic polypeptide responses in obese, prediabetic humans. Am. J. Clin. Nutr. 92, 1359-1368 (2010).
27. Solomon TP, Haus JM, Kelly KR, Rocco M, Kashyap SR, Kirwan JP. Improved pancreatic b-cell function in Type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care 33, 1561-1566 (2010).