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Volumn 21, Issue 13, 2011, Pages 1102-1110

Phosphorylation of groucho mediates RTK feedback inhibition and prolonged pathway target gene expression

Author keywords

[No Author keywords available]

Indexed keywords

BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; GROUCHO PROTEIN, DROSOPHILA; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN TYROSINE KINASE; REPRESSOR PROTEIN;

EID: 79960157899     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cub.2011.05.043     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 34547204160 scopus 로고    scopus 로고
    • The MEK/ERK cascade: From signaling specificity to diverse functions
    • DOI 10.1016/j.bbamcr.2006.10.005, PII S0167488906003193
    • Y.D. Shaul, and R. Seger The MEK/ERK cascade: From signaling specificity to diverse functions Biochim. Biophys. Acta 1773 2007 1213 1226 (Pubitemid 47125968)
    • (2007) Biochimica et Biophysica Acta - Molecular Cell Research , vol.1773 , Issue.8 , pp. 1213-1226
    • Shaul, Y.D.1    Seger, R.2
  • 2
    • 0029671192 scopus 로고    scopus 로고
    • Argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop
    • M. Golembo, R. Schweitzer, M. Freeman, and B.Z. Shilo argos transcription is induced by the Drosophila EGF receptor pathway to form an inhibitory feedback loop Development 122 1996 223 230
    • (1996) Development , vol.122 , pp. 223-230
    • Golembo, M.1    Schweitzer, R.2    Freeman, M.3    Shilo, B.Z.4
  • 3
    • 0347986681 scopus 로고    scopus 로고
    • MKP-3 Has Essential Roles as a Negative Regulator of the Ras/Mitogen-Activated Protein Kinase Pathway during Drosophila Development
    • DOI 10.1128/MCB.24.2.573-583.2004
    • M. Kim, G.H. Cha, S. Kim, J.H. Lee, J. Park, H. Koh, K.Y. Choi, and J. Chung MKP-3 has essential roles as a negative regulator of the Ras/mitogen-activated protein kinase pathway during Drosophila development Mol. Cell. Biol. 24 2004 573 583 (Pubitemid 38057910)
    • (2004) Molecular and Cellular Biology , vol.24 , Issue.2 , pp. 573-583
    • Kim, M.1    Cha, G.-H.2    Kim, S.3    Lee, J.H.4    Park, J.5    Koh, H.6    Choi, K.-Y.7    Chung, J.8
  • 5
    • 33847355217 scopus 로고    scopus 로고
    • Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate
    • DOI 10.1038/ncb1543, PII NCB1543
    • S.D. Santos, P.J. Verveer, and P.I. Bastiaens Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate Nat. Cell Biol. 9 2007 324 330 (Pubitemid 46344612)
    • (2007) Nature Cell Biology , vol.9 , Issue.3 , pp. 324-330
    • Santos, S.D.M.1    Verveer, P.J.2    Bastiaens, P.I.H.3
  • 6
    • 0037429688 scopus 로고    scopus 로고
    • Signaling by the Drosophila epidermal growth factor receptor pathway during development
    • B.Z. Shilo Signaling by the Drosophila epidermal growth factor receptor pathway during development Exp. Cell Res. 284 2003 140 149
    • (2003) Exp. Cell Res. , vol.284 , pp. 140-149
    • Shilo, B.Z.1
  • 7
    • 0036607116 scopus 로고    scopus 로고
    • Dorsal gradient networks in the Drosophila embryo
    • DOI 10.1006/dbio.2002.0652
    • A. Stathopoulos, and M. Levine Dorsal gradient networks in the Drosophila embryo Dev. Biol. 246 2002 57 67 (Pubitemid 34625975)
    • (2002) Developmental Biology , vol.246 , Issue.1 , pp. 57-67
    • Stathopoulos, A.1    Levine, M.2
  • 8
    • 0026728302 scopus 로고
    • The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
    • Y.T. Ip, R.E. Park, D. Kosman, E. Bier, and M. Levine The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo Genes Dev. 6 1992 1728 1739
    • (1992) Genes Dev. , vol.6 , pp. 1728-1739
    • Ip, Y.T.1    Park, R.E.2    Kosman, D.3    Bier, E.4    Levine, M.5
  • 9
    • 0034650255 scopus 로고    scopus 로고
    • Rhomboid and star facilitate presentation and processing of the Drosophila TGF-α homolog Spitz
    • A.G. Bang, and C. Kintner Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz Genes Dev. 14 2000 177 186 (Pubitemid 30070983)
    • (2000) Genes and Development , vol.14 , Issue.2 , pp. 177-186
    • Bang, A.G.1    Kintner, C.2
  • 10
    • 0030785482 scopus 로고    scopus 로고
    • MAP kinase in situ activation atlas during Drosophila embryogenesis
    • L. Gabay, R. Seger, and B.Z. Shilo MAP kinase in situ activation atlas during Drosophila embryogenesis Development 124 1997 3535 3541 (Pubitemid 27470037)
    • (1997) Development , vol.124 , Issue.18 , pp. 3535-3541
    • Gabay, L.1    Seger, R.2    Shilo, B.-Z.3
  • 11
    • 0030217951 scopus 로고    scopus 로고
    • Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo
    • DOI 10.1016/S0959-437X(96)80062-1
    • J. Rusch, and M. Levine Threshold responses to the dorsal regulatory gradient and the subdivision of primary tissue territories in the Drosophila embryo Curr. Opin. Genet. Dev. 6 1996 416 423 (Pubitemid 26280793)
    • (1996) Current Opinion in Genetics and Development , vol.6 , Issue.4 , pp. 416-423
    • Rusch, J.1    Levine, M.2
  • 12
    • 0025060344 scopus 로고
    • Rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster
    • E. Bier, L.Y. Jan, and Y.N. Jan rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster Genes Dev. 4 1990 190 203
    • (1990) Genes Dev. , vol.4 , pp. 190-203
    • Bier, E.1    Jan, L.Y.2    Jan, Y.N.3
  • 13
    • 0032533213 scopus 로고    scopus 로고
    • Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity
    • J.B. Weiss, T. Von Ohlen, D.M. Mellerick, G. Dressler, C.Q. Doe, and M.P. Scott Dorsoventral patterning in the Drosophila central nervous system: The intermediate neuroblasts defective homeobox gene specifies intermediate column identity Genes Dev. 12 1998 3591 3602 (Pubitemid 28553249)
    • (1998) Genes and Development , vol.12 , Issue.22 , pp. 3591-3602
    • Weiss, J.B.1    Von Ohlen, T.2    Mellerick, D.M.3    Dressler, G.4    Doe, C.Q.5    Scott, M.P.6
  • 14
    • 0034663207 scopus 로고    scopus 로고
    • Convergence of dorsal, Dpp, and Egfr signaling pathways subdivides the Drosophila neuroectoderm into three dorsal-ventral columns
    • DOI 10.1006/dbio.2000.9789
    • T. von Ohlen, and C.Q. Doe Convergence of dorsal, dpp, and egfr signaling pathways subdivides the drosophila neuroectoderm into three dorsal-ventral columns Dev. Biol. 224 2000 362 372 (Pubitemid 30661017)
    • (2000) Developmental Biology , vol.224 , Issue.2 , pp. 362-372
    • Von Ohlen, T.1    Doe, C.Q.2
  • 15
    • 11244310826 scopus 로고    scopus 로고
    • EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output
    • DOI 10.1038/ng1486
    • P. Hasson, N. Egoz, C. Winkler, G. Volohonsky, S. Jia, T. Dinur, T. Volk, A.J. Courey, and Z. Paroush EGFR signaling attenuates Groucho-dependent repression to antagonize Notch transcriptional output Nat. Genet. 37 2005 101 105 (Pubitemid 40070947)
    • (2005) Nature Genetics , vol.37 , Issue.1 , pp. 101-105
    • Hasson, P.1    Egoz, N.2    Winkler, C.3    Volohonsky, G.4    Jia, S.5    Dinur, T.6    Volk, T.7    Courey, A.J.8    Paroush, Z.9
  • 16
    • 56049107271 scopus 로고    scopus 로고
    • Context-dependent regulation of Groucho/TLE-mediated repression
    • DOI 10.1016/j.gde.2008.07.010, PII S0959437X08000890
    • E. Cinnamon, and Z. Paroush Context-dependent regulation of Groucho/TLE-mediated repression Curr. Opin. Genet. Dev. 18 2008 435 440 (Pubitemid 50262327)
    • (2008) Current Opinion in Genetics and Development , vol.18 , Issue.5 , pp. 435-440
    • Cinnamon, E.1    Paroush, Z.2
  • 17
    • 18844415873 scopus 로고    scopus 로고
    • Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo
    • DOI 10.1016/j.ydbio.2005.02.003, PII S001216060500076X
    • A. Stathopoulos, and M. Levine Localized repressors delineate the neurogenic ectoderm in the early Drosophila embryo Dev. Biol. 280 2005 482 493 (Pubitemid 40692146)
    • (2005) Developmental Biology , vol.280 , Issue.2 , pp. 482-493
    • Stathopoulos, A.1    Levine, M.2
  • 18
    • 42149130936 scopus 로고    scopus 로고
    • Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis
    • DOI 10.1242/dev.015206
    • E. Cinnamon, A. Helman, R. Ben-Haroush Schyr, A. Orian, G. Jiménez, and Z. Paroush Multiple RTK pathways downregulate Groucho-mediated repression in Drosophila embryogenesis Development 135 2008 829 837 (Pubitemid 351524137)
    • (2008) Development , vol.135 , Issue.5 , pp. 829-837
    • Cinnamon, E.1    Helman, A.2    Schyr, R.B.-H.3    Orian, A.4    Jimenez, G.5    Paroush, Z.6
  • 19
    • 0030866482 scopus 로고    scopus 로고
    • In situ activation pattern of Drosophila EGF receptor pathway during development
    • DOI 10.1126/science.277.5329.1103
    • L. Gabay, R. Seger, and B.Z. Shilo In situ activation pattern of Drosophila EGF receptor pathway during development Science 277 1997 1103 1106 (Pubitemid 27371633)
    • (1997) Science , vol.277 , Issue.5329 , pp. 1103-1106
    • Gabay, L.1    Seger, R.2    Shilo, B.-Z.3
  • 20
    • 0031666418 scopus 로고    scopus 로고
    • The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo
    • J.B. Skeath The Drosophila EGF receptor controls the formation and specification of neuroblasts along the dorsal-ventral axis of the Drosophila embryo Development 125 1998 3301 3312 (Pubitemid 28458330)
    • (1998) Development , vol.125 , Issue.17 , pp. 3301-3312
    • Skeath, J.B.1
  • 21
    • 0031706418 scopus 로고    scopus 로고
    • Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm
    • Y. Yagi, T. Suzuki, and S. Hayashi Interaction between Drosophila EGF receptor and vnd determines three dorsoventral domains of the neuroectoderm Development 125 1998 3625 3633 (Pubitemid 28469963)
    • (1998) Development , vol.125 , Issue.18 , pp. 3625-3633
    • Yagi, Y.1    Suzuki, T.2    Hayashi, S.3
  • 23
    • 0031805618 scopus 로고    scopus 로고
    • Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors
    • E. Buff, A. Carmena, S. Gisselbrecht, F. Jiménez, and A.M. Michelson Signalling by the Drosophila epidermal growth factor receptor is required for the specification and diversification of embryonic muscle progenitors Development 125 1998 2075 2086 (Pubitemid 28297794)
    • (1998) Development , vol.125 , Issue.11 , pp. 2075-2086
    • Buff, E.1    Carmena, A.2    Gisselbrecht, S.3    Jimenez, F.4    Michelson, A.M.5
  • 24
    • 0032535413 scopus 로고    scopus 로고
    • Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm
    • A. Carmena, S. Gisselbrecht, J. Harrison, F. Jiménez, and A.M. Michelson Combinatorial signaling codes for the progressive determination of cell fates in the Drosophila embryonic mesoderm Genes Dev. 12 1998 3910 3922 (Pubitemid 29024853)
    • (1998) Genes and Development , vol.12 , Issue.24 , pp. 3910-3922
    • Carmena, A.1    Gisselbrecht, S.2    Harrison, J.3    Jimenez, F.4    Michelson, A.M.5
  • 25
    • 0034730326 scopus 로고    scopus 로고
    • Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors
    • M.S. Halfon, A. Carmena, S. Gisselbrecht, C.M. Sackerson, F. Jiménez, M.K. Baylies, and A.M. Michelson Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors Cell 103 2000 63 74
    • (2000) Cell , vol.103 , pp. 63-74
    • Halfon, M.S.1    Carmena, A.2    Gisselbrecht, S.3    Sackerson, C.M.4    Jiménez, F.5    Baylies, M.K.6    Michelson, A.M.7
  • 26
    • 31544444710 scopus 로고    scopus 로고
    • Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells
    • DOI 10.1016/j.ydbio.2005.11.033, PII S0012160605008432
    • J. Liu, L. Qian, R.J. Wessells, Y. Bidet, K. Jagla, and R. Bodmer Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells Dev. Biol. 290 2006 373 385 (Pubitemid 43163499)
    • (2006) Developmental Biology , vol.290 , Issue.2 , pp. 373-385
    • Liu, J.1    Qian, L.2    Wessells, R.J.3    Bidet, Y.4    Jagla, K.5    Bodmer, R.6
  • 27
    • 0029904093 scopus 로고    scopus 로고
    • EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm
    • L. Gabay, H. Scholz, M. Golembo, A. Klaes, B.Z. Shilo, and C. Klämbt EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm Development 122 1996 3355 3362 (Pubitemid 26395978)
    • (1996) Development , vol.122 , Issue.11 , pp. 3355-3362
    • Gabay, L.1    Scholz, H.2    Golembo, M.3    Klaes, A.4    Shilo, B.-Z.5    Klambt, C.6
  • 28
    • 0029100254 scopus 로고
    • Inhibition of Drosophila EGF receptor activation by the secreted protein Argos
    • R. Schweitzer, R. Howes, R. Smith, B.Z. Shilo, and M. Freeman Inhibition of Drosophila EGF receptor activation by the secreted protein Argos Nature 376 1995 699 702
    • (1995) Nature , vol.376 , pp. 699-702
    • Schweitzer, R.1    Howes, R.2    Smith, R.3    Shilo, B.Z.4    Freeman, M.5
  • 29
    • 0036176993 scopus 로고    scopus 로고
    • Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase
    • DOI 10.1042/0264-6021:3610143
    • S.H. Kim, H.B. Kwon, Y.S. Kim, J.H. Ryu, K.S. Kim, Y. Ahn, W.J. Lee, and K.Y. Choi Isolation and characterization of a Drosophila homologue of mitogen-activated protein kinase phosphatase-3 which has a high substrate specificity towards extracellular-signal-regulated kinase Biochem. J. 361 2002 143 151 (Pubitemid 34171419)
    • (2002) Biochemical Journal , vol.361 , Issue.1 , pp. 143-151
    • Kim, S.-H.1    Kwon, H.-B.2    Kim, Y.-S.3    Ryu, J.-H.4    Kim, K.-S.5    Ahn, Y.6    Lee, W.-J.7    Choi, K.-Y.8
  • 31
    • 13844299856 scopus 로고    scopus 로고
    • CNS midline cells contribute to maintenance of the initial dorsoventral patterning of the Drosophila ventral neuroectoderm
    • DOI 10.1002/neu.20104
    • I.O. Kim, I.C. Kim, S. Kim, Y.K. Kwon, P.L. Han, S.H. Jeon, and S.H. Kim CNS midline cells contribute to maintenance of the initial dorsoventral patterning of the Drosophila ventral neuroectoderm J. Neurobiol. 62 2005 397 405 (Pubitemid 40250701)
    • (2005) Journal of Neurobiology , vol.62 , Issue.4 , pp. 397-405
    • In, O.K.1    In, C.K.2    Kim, S.3    Yeon, K.K.4    Han, P.-L.5    Jeon, S.-H.6    Sang, H.K.7
  • 32
    • 0036743611 scopus 로고    scopus 로고
    • New fluorescent protein reporters for use with the Drosophila Gal4 expression system and for vital detection of balancer chromosomes
    • M.S. Halfon, S. Gisselbrecht, J. Lu, B. Estrada, H. Keshishian, and A.M. Michelson New fluorescent protein reporters for use with the Drosophila Gal4 expression system and for vital detection of balancer chromosomes Genesis 34 2002 135 138
    • (2002) Genesis , vol.34 , pp. 135-138
    • Halfon, M.S.1    Gisselbrecht, S.2    Lu, J.3    Estrada, B.4    Keshishian, H.5    Michelson, A.M.6
  • 33
    • 0036715018 scopus 로고    scopus 로고
    • Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing
    • DOI 10.1101/gad.991102
    • D.A. Prober, and B.A. Edgar Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing Genes Dev. 16 2002 2286 2299 (Pubitemid 35013091)
    • (2002) Genes and Development , vol.16 , Issue.17 , pp. 2286-2299
    • Prober, D.A.1    Edgar, B.A.2
  • 34
    • 1842377431 scopus 로고    scopus 로고
    • Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression
    • Z. Paroush, S.M. Wainwright, and D. Ish-Horowicz Torso signalling regulates terminal patterning in Drosophila by antagonising Groucho-mediated repression Development 124 1997 3827 3834 (Pubitemid 27482979)
    • (1997) Development , vol.124 , Issue.19 , pp. 3827-3834
    • Paroush, Z.1    Mark Wainwright, S.2    Ish-Horowicz, D.3
  • 36
    • 0343986271 scopus 로고    scopus 로고
    • Relief of gene repression by Torso RTK signaling: Role of capicua in Drosophila terminal and dorsoventral patterning
    • G. Jiménez, A. Guichet, A. Ephrussi, and J. Casanova Relief of gene repression by torso RTK signaling: Role of capicua in Drosophila terminal and dorsoventral patterning Genes Dev. 14 2000 224 231 (Pubitemid 30070987)
    • (2000) Genes and Development , vol.14 , Issue.2 , pp. 224-231
    • Jimenez, G.1    Guichet, A.2    Ephrussi, A.3    Casanova, J.4
  • 37
    • 0036336980 scopus 로고    scopus 로고
    • EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins
    • F. Roch, G. Jiménez, and J. Casanova EGFR signalling inhibits Capicua-dependent repression during specification of Drosophila wing veins Development 129 2002 993 1002 (Pubitemid 34874123)
    • (2002) Development , vol.129 , Issue.4 , pp. 993-1002
    • Roch, F.1    Jimenez, G.2    Casanova, J.3
  • 38
    • 33846946102 scopus 로고    scopus 로고
    • A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling
    • S. Astigarraga, R. Grossman, J. Díaz-Delfín, C. Caelles, Z. Paroush, and G. Jiménez A MAPK docking site is critical for downregulation of Capicua by Torso and EGFR RTK signaling EMBO J. 26 2007 668 677
    • (2007) EMBO J. , vol.26 , pp. 668-677
    • Astigarraga, S.1    Grossman, R.2    Díaz-Delfín, J.3    Caelles, C.4    Paroush, Z.5    Jiménez, G.6
  • 39
    • 33847055023 scopus 로고    scopus 로고
    • Identification of an upstream regulatory element reveals a novel requirement for Ind activity in maintaining ind expression
    • DOI 10.1016/j.mod.2006.11.003, PII S0925477306002139
    • T.L. Von Ohlen, C. Harvey, and M. Panda Identification of an upstream regulatory element reveals a novel requirement for Ind activity in maintaining ind expression Mech. Dev. 124 2007 230 236 (Pubitemid 46274189)
    • (2007) Mechanisms of Development , vol.124 , Issue.3 , pp. 230-236
    • Von Ohlen, T.L.1    Harvey, C.2    Panda, M.3
  • 41
    • 0027333321 scopus 로고
    • Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras
    • T.B. Chou, E. Noll, and N. Perrimon Autosomal P[ovoD1] dominant female-sterile insertions in Drosophila and their use in generating germ-line chimeras Development 119 1993 1359 1369
    • (1993) Development , vol.119 , pp. 1359-1369
    • Chou, T.B.1    Noll, E.2    Perrimon, N.3
  • 42
    • 79952111781 scopus 로고    scopus 로고
    • Detection of RTK pathway activation in Drosophila using anti-dpERK immunofluorescence staining
    • A. Helman, and Z. Paroush Detection of RTK pathway activation in Drosophila using anti-dpERK immunofluorescence staining Methods Mol. Biol. 661 2010 401 408
    • (2010) Methods Mol. Biol. , vol.661 , pp. 401-408
    • Helman, A.1    Paroush, Z.2


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