Tadalafil alters energy metabolism in C2C12 skeletal muscle cells

Acta Biochimica Polonica

Volumn 58, Issue 2, 2011, Pages 237-241

  Sabatini, Stefania ^a   Sgrò, Paolo ^a   Duranti, Guglielmo ^a   Ceci, Roberta ^a   Di Luigi, Luigi ^a  

^a UNIVERSITY OF ROME FORO ITALICO   (Italy)

Author keywords

Aerobic enzymes; Lactate; Phosphodiesterase type 5 inhibitor

Indexed keywords

ACYL COENZYME A DEHYDROGENASE; CARBOLINE DERIVATIVE; CITRATE SYNTHASE; GLUCOSE; LACTIC ACID; PDE5A PROTEIN, MOUSE; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR; TADALAFIL;

ANIMAL; ARTICLE; CHEMISTRY; DRUG EFFECT; ENERGY METABOLISM; ENZYME ASSAY; ENZYMOLOGY; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOUSE; SKELETAL MUSCLE;

ACYL-COA DEHYDROGENASE; ANIMALS; CARBOLINES; CITRATE (SI)-SYNTHASE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; ENERGY METABOLISM; ENZYME ASSAYS; GLUCOSE; LACTIC ACID; MICE; MUSCLE FIBERS, SKELETAL; PHOSPHODIESTERASE 5 INHIBITORS; TRANSCRIPTION, GENETIC;

EID: 79960133580     PISSN: 0001527X     EISSN: 1734154X     Source Type: Journal    
DOI: None     Document Type: Article

References (24)

1. Ayala JE, Bracy DP, Julien BM, Rottman JN, Fueger PT, Wasserman DH (2007) Chronic treatment with sildenafil improves energy balance and insulin action in high fat-fed conscious mice. Diabetes 56: 1025-1033.
2. Catani MV, Savini I, Duranti G, Caporossi D, Ceci R, Sabatini S, Avigliano L (2004) NF-KB and AP-1 are involved in differentiationmediated resistance to oxidative stress in skeletal muscle cell lines. Free Rad Biol Med 37: 1024-1036.
3. Cheng CL, Chou CH (2005) Determination of Tadalafil in small volumes of plasma by high-performance liquid chromatography with UV detection. J Chromatogr B Analyt Technol Biomed Life Sci 822: 278-284.
4. Corbin JD, Francis SH (2002) Pharmacology of phosphodiesterase-5 inhibitors. Int J Clin Pract 56: 453-459.
5. Di Luigi L, Baldari C, Sgrò P, Emerenziani GP, Gallotta MC, Bianchini S, Romanelli F, Pigozzi F, Lenzi A, Guidetti L (2008a) The type 5 phosphodiesterase inhibitor Tadalafil influences salivary cortisol, testosterone, and dehydroepiandrosterone sulphate responses to maximal exercise in healthy men. J Clin Endocrinol Metab 93: 3510-3514.
6. Di Luigi L, Baldari C, Pigozzi F, Emerenziani GP, Gallotta MC, Iellamo F, Ciminelli E, Sgrò P, Romanelli F, Lenzi A, Guidetti (2008b) The long-acting phosphodiesterase inhibitor Tadalafil does not influence athletes' VO2max, aerobic, and anaerobic thresholds in normoxia. Int J Sports Med 29: 110-115.
7. Dickinson NT, Jang EK, Haslam RJ (1997) Activation of cGMP-stimulated phosphodiesterase by nitroprusside limits cAMP accumulation in human platelets: effects on platelet aggregation. Biochem J 323: 371-377.
8. Essen-Gustavsson B, Henriksson J (1984) Enzyme levels in pools of microdissected human muscle fibers of identified type. Adaptative response to exercise. Acta Physiol Scand 120: 505-515.
9. Flores Rodríguez J, Berzas Nevado JJ, Castañeda Peñalvo G, Mora Diez N (2004) Development of a micellar electrokinetic capillary chromatography method for the determination of three drugs employed in the erectile dysfunction therapy. J Chromatogr B Analyt Technol Biomed Life Sci 811: 231-236.
10. Guidetti L, Emerenziani GP, Gallotta MC, Pigozzi F, Di Luigi L, Baldari C (2008) Effect of Tadalafil on anaerobic performance indices in healthy athletes. Br J Sports Med 42: 130-133.
11. Haas B, Mayer P, Jennissen K, Scholz D, Diaz MB, Bloch W, Herzig S, Fässler R, Pfeifer A (2009) Protein kinase G controls brown fat cell differentiation and mitochondrial biogenesis. Sci Signal 2: ra78.
12. Jansson PA, Murdolo G, Sjögren L, Nyström B, Sjöstrand M, Strindberg L, Lönnroth P (2010) Tadalafil increases muscle capillary recruitment and forearm glucose uptake in women with type 2 diabetes. Diabetologia. 53: 2205-2208.
13. Kulkarni SK, Patil CS (2004) Phosphodiesterase 5 enzyme and its inhibitors: update on pharmacological and therapeutical aspects. Methods Find Exp Clin Pharmacol 26: 789-799.
14. Liu L, Zheng S, Han P, Wei Q (2011) Phosphodiesterase-5 inhibitors for lower urinary tract symptoms secondary to benign prostatic hyperplasia: a systematic review and meta-analysis. Urology 77: 123-129.
15. Li L, Yee C, Beavo JA (1999) CD3- and CD28-dependent induction of PDE7 required for T cell activation. Science 283: 848-851.
16. Loughney K, Hill TR, Florio VA, Uher L, Rosman GJ, Wolda SL, Jones BA, Howard ML, McAllister-Lucas LM, Sonnenburg WK, Francis SH, Corbin JD, Beavo JA, Ferguson K (1998) Isolation and characterization of cDNAs encoding PDE5A, a human cGMPbinding, cGMP-specific 3′,5′-cyclic nucleotide phosphodiesterase. Gene 216: 139-147.
17. Mitsuishi M, Miyashita K, Itoh H (2008) cGMP rescues mitochondrial dysfunction induced by glucose and insulin in myocytes. Biochem Biophys Res Commun 367: 840-845.
18. Mounier R, Cavaliè H, Lac G, Clottes E (2007) Molecular impact of clenbuterol and isometric strenght training on rat EDL mucles. Pflugers Arch-Eur J Physiol 453: 497-507.
19. Omori K, Kotera J (2007) Overview of PDEs and their regulation. Circ Res 100: 309-327.
20. Salloum FN, Chau VQ, Hoke NN, Abbate A, Varma A, Ockaili RA, Toldo S, Kukreja RC (2009) Phosphodiesterase-5 inhibitor, Tadalafil, protects against myocardial ischemia/reperfusion through protein-kinase G-dependent generation of hydrogen sulphide. Circulation 120: S31-S36.
21. Soderling SH, Beavo JA (2000) Regulation of cAMP and cGMP signalling: new phosphodiesterases and new functions. Curr Opin Cell Biol 12: 174-179.
22. Srere PA (1969) Citrate synthase. Methods Enzymol 13: 3-11.
23. Vachiery JL, Huez S, Gillies H, Layton G, Hayashi N, Gao X, Naeije R (2011) Safety, tolerability and pharmacokinetics of an intravenous bolus of sildenafil in patients with pulmonary arterial hypertension. Br J Clin Pharmacol 7: 289-292.
24. Vernet D, Magee T, Qian A, Nolazco G, Rajfer J, Gonzalez-Cadavid N (2006) Phosphodiesterase type 5 is not upregulated by tadalafil in cultures of human penile cells. J Sex Med. 3: 84-94.