The influence of RBE variations in a clinical proton treatment plan for a hypopharynx cancer

Physics in Medicine and Biology

Volumn 50, Issue 12, 2005, Pages 2765-2777

  Tilly, N ^a   Johansson, J ^a   Isacsson, U ^a   Medin, J ^b   Blomquist, E ^a   Grusell, E ^a   Glimelius, B ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

DOSIMETRY; LIGHT; PARAMETER ESTIMATION; PROBABILITY; PROTONS; TISSUE;

CLINICAL PROTONS; CLINICAL TARGET VOLUMES; RELATIVE BIOLOGICAL EFFECTIVENESS (RBE); TUMOR CONTROL PROBABILITY;

BRAGG CELLS;

ARTICLE; CANCER CONTROL; HUMAN; HYPOPHARYNX CARCINOMA; LINEAR ENERGY TRANSFER; LYMPH NODE; PRIORITY JOURNAL; RADIATION DOSE; RELATIVE BIOLOGIC EFFECTIVENESS; TREATMENT PLANNING;

CARCINOMA, SQUAMOUS CELL; HUMANS; HYPOPHARYNGEAL NEOPLASMS; LYMPH NODES; MODELS, BIOLOGICAL; PHANTOMS, IMAGING; PROTONS; RADIOTHERAPY PLANNING, COMPUTER-ASSISTED;

EID: 20044388910     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/50/12/003     Document Type: Article

References (39)

1. Ågren Cronqvist A-K 1995 Quantification of the response of heterogeneous tumours and organized normal tissues to fractionated radiotherapy PhD Thesis Medical Radiation Physics, Stockholm University
2. Austin-Seymour M et al 1985 Progress in low-LET heavy particle therapy: intracranial and paracranial tumors and uveal melanomas Radiat. Res. 104 219-26
3. Belli M et al 2000 Inactivation of human normal and tumour cells irradiated with low energy protons Int. J. Radiat. Biol. 76 831-9
4. Belli M et al 1998 RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility. Int. J. Radiat. Biol. 74 501-9
5. Belli M, Campa A and Ermolli I 1997 A semi-empirical approach to the evaluation of the relative biological effectiveness of therapeutic proton beams: the methodological framework Radiat. Res. 148 592-8
6. Belli M, Cera F, Cherubini R, Haque A M I, Ianzini F, Moschini G, Sapora O, Simone G, Tabocchini M A and Tiveron P 1993 Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility Int. J. Radiat. Biol. 63 331-7
7. Bettega D et al 1998 Inactivation of C3H10T1/2 cells by low energy protons and deuterons Int. J. Radiat. Biol. 73 303-9
8. Courdi A, Brassart N, Hérault I and Chauvel P 1994 The depth-dependent radiation response of human melanoma cells exposed to 65 MeV protons Br. J. Radiol. 67 800-804
9. Cozzi L, Fogliata A, Lomax A and Bolsi A 2001 A treatment planning comparison of 3D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours Radiother. Oncol. 61 287-97
10. Dale R G and Jones B 1999 The assessment of RBE effects using the concept of biologically effective dose Int. J. Radiat. Oncol. Biol. Phys. 43 639-45
11. Folkard M, Prise K M, Vojnovic B, Newman H C, Roper M J and Michael B D 1996 Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions Int. J. Radiat. Biol. 69 729-38
12. Fowler J F 2001 Biological factors influencing optimum fractionation in radiation therapy Acta Oncol. 40 712-17
13. Gerweck L E and Kozin S V 1999 Relative biological effectiveness of proton beams in clinical therapy Radiother. Oncol. 50 135-42
14. Gueulette J et al 2000 Proton relative biological effectiveness (RBE) for survival in mice after thoracic irradiation with fractionated doses Int. J. Radiat. Oncol. Biol. Phys. 47 1051-8
15. Hawkins R B 1998 A microdosimetric-kinetic theory of the dependence of the RBE for cell death on LET Med. Phys. 25 1157-70
16. ICRU 1993 Prescribing, recording and reporting photon beam therapy ICRU Report 50 (Bethesda, MD: ICRU)
17. ICRU 1999 Prescribing, recording and reporting photon beam therapy (Supplement to ICRU Report 50) ICRU Report 62 (Bethesda, MD: ICRU)
18. Jung B, Montelius A and Dahlin H 1997 The conceptual design of a radiation oncology planning system Comput. Methods Programs Biomed. 52 79-92
19. Källman P, Ågren A and Brahme A 1992 Tumour and normal tissue responses to fractionated non-uniform dose delivery Int. J. Radiat. Biol. 62 249-62
20. Kanai T, Furusawa Y, Fukutsu K, Itsukaichi H, Eguchi-Kasai K and Ohara H 1997 Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy Radiat. Res. 147 78-85
21. Kraft G 2000 Tumor therapy with heavy charged particles Prog. Part. Nucl. Phys. 45 S473-S544
22. Larsson B and Kihlman B A 1960 Chromosome aberrations following irradiation with high-energy protons and their secondary radiation: a study of dose distribution and biological efficiency using root-tips of Vicia faba and Allium cepa Int. J. Radiat. Biol. 2 8-19
23. Mavroidis P, Lind B K and Brahme A 2001 Biologically effective uniform dose (D) for specification, report and comparison of dose-response relations and treatment plans Phys. Med. Biol. 46 2607-30
24. Medin J and Andreo P 1997 PETRA-Monte Carlo simulation of proton and electron transport in water Internal Report MSF 1997-01 (Stockholm: Stockholm University)
25. Mohan R, Wu Q, Manning M and Schmidt-Ullrich R 2000 Radiobiological considerations in the design of fractionation strategies for intensity-modulated radiation therapy of head and neck cancers Int. J. Radiat. Oncol. Biol. Phys. 46 619-30
26. Montelius A, Blomquist E and Naeser P 1991 The narrow proton beam therapy unit at The Svedberg Laboratory in Uppsala Acta Oncol. 30 739-45
27. Paganetti H 2003 Significance and implementation of RBE variations in proton beam therapy Technol. Cancer Res. Treat. 2 413-26
28. Paganetti H 1998 Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment Phys. Med. Biol. 43 2147-57
29. Paganetti H and Schmitz T 1996 The influence of the modulation technique on dose and RBE in proton radiation therapy Phys. Med. Biol. 41 1649-63
30. Paganetti H, Olko P, Kobus H, Becker R, Schmitz T, Waligorski M P R, Filges D and Müller-Gärtner H W 1997 Calculation of relative biological effectiveness for proton beams using biological weighting functions Int. J. Radiat. Oncol. Biol. Phys. 37 719-29
31. Robertson J B, Williams J R, Schmidt R A, Little J B, Flynn D F and Suit H D 1975 Radiobiological studies of high-energy modulated proton beam utilizing cultured mammalian cells Cancer 35 1664-77
32. Russell K R, Isacsson U, Saxner M, Ahnesjö A, Montelius A, Grusell E, Vallhagen-Dahlgren C, Lorin S and Glimelius B 2000 Implementation of pencil kernel and depth penetration algorithms for treatment planning of proton beams Phys. Med. Biol. 45 9-27
33. Suit H D, Goldberg S, Niemerko A, Tromifov A, Adams I, Paganetti H, Chen G T Y, Bortfeld T, Rosenthal S, Loeffler J and Delaney T 2003 Proton beams to replace photon beams in radical dose treatments Acta Oncol. 42 800-8
34. Sweet W H, Kjellberg R N, Field R A, Koehler A M and Preston W M 1967 Time-intensity data in solar cosmic-ray events: biological data relevant to their effects in man Radiat. Res. 1 (Suppl.) 369-83
35. Tilly N 2002 Radiobiological investigations of proton and light ion therapy PhD Thesis Stockholm University
36. Tilly N, Brahme A, Carlsson J and Glimelius B 1999 Comparison of cell survival models for mixed LET radiation Int. J. Radiat. Biol. 75 233-43
37. Weyrather W K, Ritter S, Scholz M and Kraft G 1999 RBE for carbon track-segment irradiation in cell lines of differing repair capacity. Int. J. Radiat. Biol. 75 1357-64
38. Wilkens J J and Oelfke U 2004 A phenomenological model for the relative biological effectiveness in therapeutic proton beams Phys. Med. Biol. 49 2811-25
39. Withers H R, Peters L J and Taylor J M G 1995 Dose-response relationship for radiation therapy of subclinical disease Int. J. Radiat. Oncol. Biol. Phys. 31 353-9