A phenomenological model for the relative biological effectiveness in therapeutic proton beams

Physics in Medicine and Biology

Volumn 49, Issue 13, 2004, Pages 2811-2825

  Wilkens, J J ^a   Oelfke, U ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MATHEMATICAL MODELS; PATIENT TREATMENT; PROTONS; TISSUE;

LINEAR ENERGY TRANSFER (LET); PROTON THERAPY; RELATIVE BIOLOGICAL EFFECTIVENESS (RBE);

BIOMEDICAL ENGINEERING;

COBALT 60;

ALPHA RADIATION; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BEAM THERAPY; BETA RADIATION; CONTROLLED STUDY; DOSIMETRY; EXPERIMENTAL MODEL; FAST PROTON RADIATION; LINEAR ENERGY TRANSFER; MATHEMATICAL ANALYSIS; MATHEMATICAL MODEL; MONTE CARLO METHOD; NONHUMAN; PHENOMENOLOGY; PRIORITY JOURNAL; RADIATION DOSE; RADIOLOGICAL PARAMETERS; RELATIVE BIOLOGIC EFFECTIVENESS;

ANIMALS; CELL LINE; CELLS, CULTURED; CRICETINAE; HUMANS; MODELS, THEORETICAL; NEOPLASMS; PROTONS; RADIOTHERAPY; RELATIVE BIOLOGICAL EFFECTIVENESS; TIME FACTORS;

EID: 3442895110     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/49/13/004     Document Type: Article

References (54)

1. Ando K, Furusawa Y, Suzuki M, Nojima K, Majima H, Koike S, Aoki M, Shimizu W, Futami Y, Ogino T, Murayama S and Ikeda H 2001 Relative biological effectiveness of the 235 MeV proton beams at the National Cancer Center Hospital East J. Radiat. Res. 42 79-89
2. Barendsen G W 2000 RBE as a function of dose for effects on tissues and tumors assessed by the linear-quadratic model (letter) Int. J. Radiat. Oncol. Biol. Phys. 46 684-5
3. Belli M, Cera F, Cherubini R, Haque A M I, Ianzini F, Moschian G, Sapora O, Simone G, Tabocchini M A and Tiveron P 1993 Inactivation and mutation induction in V79 cells by low energy protons: re-evaluation of the results at the LNL facility Int. J. Radiat. Biol. 63 331-7
4. Belli M, Campa A and Ermolli I 1997 A semi-empirical approach to the evaluation of the relative biological effectiveness of therapeutic proton beams: the methodological framework Radiat. Res. 148 592-8
5. Belli M, Cera F, Cherubini R, Dalla Vecchia M, Haque A M I, Ianzini F, Moschini G, Sapora O, Simone G, Tabocchini M A and Tiveron P 1998 RBE-LET relationships for cell inactivation and mutation induced by low energy protons in V79 cells: further results at the LNL facility Int. J. Radiat. Biol. 74 501-9
6. Berger M J 1993 Penetration of Proton Beams Through Water I. Depth-Dose Distribution, Spectra and LET Distribution (NISTIR Publication 5226) (Gaithersburg, MD: National Institute of Standards and Technology)
7. Bettega D, Calzolari P, Chauvel P, Courdi A, Herault J, Iborra N, Marchesini R, Massariello P, Poli G L and Tallone L 2000 Radiobiological studies on the 65 MeV therapeutic proton beam at Nice using human tumour cells Int. J. Radiat. Biol. 76 1297-303
8. 60Co gamma-radiation using two cell lines Radiother. Oncol. 2844-51
9. Butts J J and Katz R 1967 Theory of RBE for heavy ion bombardment of dry enzymes and viruses Radiat. Res. 30 855-71
10. Chapman J D, Blakely E A, Smith K C and Urtasun R C 1977 Radiobiological characterization of the inactivating events produced in mammalian cells by helium and heavy ions Int. J. Radiat. Oncol. Biol. Phys. 3 97-102
11. Courdi A, Brassart N, Hérault J and Chauvel P 1994 The depth-dependent radiation response of human melanoma cells exposed to 65 MeV protons Br. J. Radiol. 67 800-4
12. Coutrakon G, Cortese J, Ghebremedhin A, Hubbard J, Johanning J, Koss P, Maudsley G, Slater C R, Zuccarelli C and Robertson J 1997 Microdosimetry spectra of the Loma Linda proton beam and relative biological effectiveness comparisons Med. Phys. 24 1499-506
13. Dale R G and Jones B 1999 The assessment of RBE effects using the concept of biologically effective dose Int. J. Radiat. Oncol. Biol. Phys. 43 639-45
14. Denekamp J, Waites T and Fowler J F 1997 Predicting realistic RBE values for clinically relevant radiotherapy schedules Int. J. Radiat. Biol. 71681-94
15. Folkard M, Prise K M, Vojnovic B, Newman H C, Roper M J and Michael B D 1996 Inactivation of V79 cells by low-energy protons, deuterons and helium-3 ions Int. J. Radiat. Biol. 69 729-38
16. Gerweck L E and Kozin S V 1999 Relative biological effectiveness of proton beams in clinical therapy Radiother. Oncol. 50 135-42
17. Goodhead D T, Belli M, Mill A J, Bance D A, Allen L A, Hall S C, Ianzani F, Simone G, Stevens D L, Stretch A, Tabocchini M A and Wilkinson R E 1992 Direct comparison between protons and alpha-particles of the same LET: I. Irradiation methods and inactivation of asynchronous V79, HeLa and C3H 10T 1/2 cells Int. J. Radiat. Biol. 61 611-24
18. Gueulette J, Slabbert J P, Böhm L, De Coster B M, Rosier J-F, Octave-Prignot M, Ruifrok A, Schreuder A N, Wambersie A, Scalliet P and Jones D T L 2001 Proton RBE for early intestinal tolerance in mice after fractionated irradiation Radiother. Oncol. 61 177-84
19. Hall E J, Kellerer A M, Rossi H H and Lam Y P 1978 The relative biological effectiveness of 160 MeV protons - II Int. J. Radiat. Oncol. Biol. Phys. 4 1009-13
20. Hawkins R B 1998 A microdosimetric-kinetic theory of the dependence of the RBE for cell death on LET Med. Phys. 25 1157-70
21. Hawkins R B 2003 A microdosimetric-kinetic model for the effect of non-Poisson distribution of lethal lesions on the variation of RBE with LET Radiat. Res. 160 61-9
22. ICRP 1989 RBE for Deterministic Effects (ICRP Publication 58) (Oxford: Pergamon)
23. ICRU 1993 Stopping Powers and Ranges for Protons and Alpha Particles (ICRU Report 49) (Bethesda, MD: International Commission on Radiation Units and Measurements)
24. ICRU 2000 Nuclear Data for Neutron and Proton Radiotherapy and for Radiation Protection (ICRU Report 63) (Bethesda, MD: International Commission on Radiation Units and Measurements)
25. Joiner M C and Field S B 1988 The response of mouse skin to irradiation with neutrons from the 62 MV cyclotron at Clatterbridge, U.K. Radiother. Oncol. 12 153-66
26. Joiner M C, Marples B, Lambin P, Short S C and Turesson I 2001 Low-dose hypersensitivity: current status and possible mechanisms Int. J. Radiat. Oncol. Biol. Phys. 49 379-89
27. Kanai T, Furusawa Y, Fukutsu K, Itsukaichi H, Eguchi-Kasai K and Ohara H 1997 Irradiation of mixed beam and design of spread-out Bragg peak for heavy-ion radiotherapy Radiat. Res. 147 78-85
28. Katz R, Ackerson B, Homayoonfar M and Sharma S C 1971 Inactivation of cells by heavy ion bombardment Radiat. Res. 47 402-25
29. Kellerer A M and Rossi H H 1978 A generalized formulation of dual radiation action Radiat. Res. 75 471-88
30. Kliauga P J, Colvett R D, Lam Y P and Rossi H H 1978 The relative biological effectiveness of 160 MeV protons Int. J. Radiat. Oncol. Biol. Phys. 4 1001-8
31. Kraft G 2000 Tumor therapy with heavy charged particles Prog. Part. Nucl. Phys. 45 (Suppl. 2) S473-S544
32. Lam G K Y 1987 The survival response of a biological system to mixed radiations Radiat. Res. 110 232-43
33. Neary G J 1965 Chromosome aberrations and the theory of RBE Int. J. Radiat. Biol. 9 477-502
34. Paganetti H 1998 Calculation of the spatial variation of relative biological effectiveness in a therapeutic proton field for eye treatment Phys. Med. Biol. 43 2147-57
35. Paganetti H 2002 Nuclear interactions in proton therapy: dose and relative biological effect distributions originating from primary and secondary particles Phys. Med. Biol. 47 747-64
36. Paganetti H and Goitein M 2000 Radiobiological significance of beamline dependent proton energy distributions in a spread-out Bragg peak Med. Phys. 27 1119-26
37. Paganetti H and Goitein M 2001 Biophysical modelling of proton radiation effects based on amorphous track models Int. J. Radiat. Biol. 77 911-28
38. Paganetti H, Niemierko A, Ancukiewicz M, Gerweek L E, Goitein M, Loeffler J S and Suit H D 2002 Relative biological effectiveness (RBE) values for proton beam therapy Int. J. Radiat. Oncol. Biol. Phys. 53 407-21
39. Perris A, Pialoglou P, Katsanos A A and Sideris E G 1986 Biological effectiveness of low energy protons. I. Survival of Chinese hamster cells Int. J. Radiat. Biol. 50 1093-101
40. Robertson J B, Williams J R, Schmidt R A, Little J B, Flynn D F and Suit H D 1975 Radiobiological studies of a high-energy modulated proton beam utilizing cultured mammalian cells Cancer 35 1664-77
41. Schettino G, Folkard M, Prise K M, Vojnovic B, Bowey A G and Michael B D 2001 Low-dose hypersensitivity in Chinese hamster V79 cells targeted with counted protons using an charged-particle microbeam Radiat. Res. 156 526-34
42. Schmid E, Roos H, Rimpl G and Bauchinger M 1997 Chromosome aberration frequencies in human lymphocytes irradiated in a multi-layer array by protons with different LET Int. J. Radiat. Biol. 72 661-5
43. Scholz M and Kraft G 1994 Calculation of heavy ion inactivation probabilities based on track structure, X ray sensitivity and target size Radiat. Prot. Dosim. 52 29-33
44. Scholz M, Kellerer A M, Kraft-Weyrather W and Kraft G 1997 Computation of cell survival in heavy ion beams for therapy. The model and its approximation Radiat. Environ. Biophys. 36 59-66
45. Skarsgard L D 1998 Radiobiology with heavy charged particles: a historical review Phys. Med. XIV (Suppl. 1) 1-19
46. 60Co γ-rays, 55 kVp X-rays, 250 kVp X-rays, and 11 MeV electrons at low doses Int. J. Radiat. Biol. 61345-53
47. Tang J T, Inoue T, Yamazaki H, Fukushima S, Fournier-Bidoz N, Koizumi M, Ozeki S and Hatanaka K 1997 Comparison of radiobiological effective depths in 65-MeV modulated proton beams Br. J. Cancer 76 220-5
48. Tepper J, Verhey L, Goitein M, Suit H D and Koehler A M 1977 In vivo determinations of RBE in a high energy modulated proton beam using normal tissue reactions and fractionated dose schedules Int. J. Radiat. Oncol. Biol. Phys. 2 1115-22
49. Tilly N, Brahme A, Carlsson J and Glimelius B 1999 Comparison of cell survival models for mixed LET radiation Int. J. Radiat. Biol. 75 233-43
50. Tilly N 2002 Radiobiological investigations of proton and light ion therapy PhD thesis Stockholm University
51. Wilkens J J and Oelfke U 2003 Analytical linear energy transfer calculations for proton therapy Med. Phys. 30 806-15
52. Wilkens J J and Oelfke U 2004 Three-dimensional LET calculations for treatment planning of proton therapy Z. Med. Phys. 14 41-46
53. Wouters B G, Lam G K Y, Oelfke U, Gardey K, Durand R E and Skarsgard L D 1996 Measurements of relative biological effectiveness of the 70 MeV proton beam at TRIUMF using Chinese hamster V79 cells and the high-precision cell sorter assay Radiat. Res. 146 159-70
54. Zaider M and Rossi H H 1980 The synergistic effects of different radiations Radiat. Res. 83 732-9