The role of platelet factor 4 in radiation-induced thrombocytopenia

International Journal of Radiation Oncology Biology Physics

Volumn 80, Issue 5, 2011, Pages 1533-1540

  Lambert, Michele P ^a,b   Xiao, Liqing ^a   Nguyen, Yvonne ^a   Kowalska, M Anna ^a,c   Poncz, Mortimer ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c INSTITUTE OF MEDICAL BIOLOGY   (Poland)

Author keywords

Chemokines; Cytokines; Platelet factor 4; Radiation induced thrombocytopenia; Thrombopoietin

Indexed keywords

CHEMOKINES; CYTOKINES; PLATELET FACTOR 4; RADIATION-INDUCED; THROMBOPOIETIN;

ANTIBODIES; MAMMALS; RECOVERY;

PLATELETS;

LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; THROMBOCYTE ANTIBODY; THROMBOCYTE FACTOR 4; THROMBOPOIETIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; MALE; MEGAKARYOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RADIATION INDUCED THROMBOCYTOPENIA; RADIATION INJURY; THROMBOCYTE COUNT; THROMBOCYTE LIFESPAN; THROMBOCYTOPENIA;

ANIMALS; BLOOD PLATELETS; BONE MARROW; CELL SURVIVAL; COLONY-FORMING UNITS ASSAY; CULTURE MEDIA, CONDITIONED; HUMANS; MEGAKARYOCYTES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; PLATELET COUNT; PLATELET FACTOR 4; RECEPTORS, LDL; THROMBOCYTOPENIA; THROMBOPOIESIS; THROMBOPOIETIN; TUMOR SUPPRESSOR PROTEINS;

EID: 79960097509     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.03.039     Document Type: Article

References (29)

1. A. Kaser, G. Brandacher, and W. Steurer Interleukin-6 stimulates thrombopoiesis through thrombopoietin: Role in inflammatory thrombocytosis Blood 98 2001 2720 2725
2. M. Majka, A. Janowska-Wieczorek, and J. Ratajczak Stromal-derived factor 1 and thrombopoietin regulate distinct aspects of human megakaryopoiesis Blood 96 2000 4142 4151
3. N.S. Weich, M. Fitzgerald, and A. Wang Recombinant human interleukin-11 synergizes with steel factor and interleukin-3 to promote directly the early stages of murine megakaryocyte development in vitro Blood 95 2000 503 509 (Pubitemid 30041662)
4. M.P. Lambert, L. Rauova, and M. Bailey Platelet factor 4 is a negative autocrine in vivo regulator of megakaryopoiesis: Clinical and therapeutic implications Blood 110 2007 1153 1160 (Pubitemid 47281411)
5. M.M. Pillai, M. Iwata, and N. Awaya Monocyte-derived CXCL7 peptides in the marrow microenvironment Blood 107 2006 3520 3526
6. A.M. Gewirtz, J. Zhang, and J. Ratajczak Chemokine regulation of human megakaryocytopoiesis Blood 86 1995 2559 2567
7. M. Majka, A. Janowska-Wieczorek, and J. Ratajczak Numerous growth factors, cytokines, and chemokines are secreted by human CD34(+) cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner Blood 97 2001 3075 3085
8. M.P. Lambert, Y. Wang, and K.H. Bdeir Platelet factor 4 regulates megakaryopoiesis through low density lipoprotein receptor related protein 1 (LRP1) on megakaryocytes Blood 114 2009 2290 2298
9. R.L. Bick, J.F. Strauss, and E.P. Frenkel Thrombosis and hemorrhage in oncology patients Hematol Oncol Clin North Am 10 1996 875 907 (Pubitemid 26240364)
10. P. Mauch, L. Constine, and J. Greenberger Hematopoietic stem cell compartment: Acute and late effects of radiation therapy and chemotherapy Int J Radiat Oncol Biol Phys 31 1995 1319 1339
11. N. Dainiak Hematologic consequences of exposure to ionizing radiation Exp Hematol 30 2002 513 528 (Pubitemid 34632623)
12. F.A. Mettler Jr., and G.L. Voelz Major radiation exposure - what to expect and how to respond N Engl J Med 346 2002 1554 1561 (Pubitemid 34755696)
13. D.R. Stickney, C. Dowding, and S. Authier 5-androstenediol improves survival in clinically unsupported rhesus monkeys with radiation-induced myelosuppression Int Immunopharmacol 7 2007 500 505 (Pubitemid 46275559)
14. D.J. Kuter Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia Annu Rev Public Health 60 2009 193 206
15. D.J. Kuter New drugs for familiar therapeutic targets: Thrombopoietin receptor agonists and immune thrombocytopenic purpura Eur J Haematol Suppl 2008 9 18 (Pubitemid 351164897)
16. C. Zhang, M.A. Thornton, and M.A. Kowalska Localization of distal regulatory domains in the megakaryocyte-specific platelet basic protein/platelet factor 4 gene locus Blood 98 2001 610 617
17. D.E. Eslin, C. Zhang, and K.J. Samuels Transgenic mice studies demonstrate a role for platelet factor 4 in thrombosis: Dissociation between anticoagulant and antithrombotic effect of heparin Blood 104 2004 3173 3180 (Pubitemid 39507132)
18. G.J. Spangrude, S. Heimfeld, and I.L. Weissman Purification and characterization of mouse hematopoietic stem cells Science 241 1988 58 62
19. A.M. Gewirtz, B. Calabretta, and B. Rucinski Inhibition of human megakaryocytopoiesis in vitro by platelet factor 4 (PF4) and a synthetic COOH-terminal PF4 peptide J Clin Invest 83 1989 1477 1486 (Pubitemid 19124100)
20. K. Kaushansky Determinants of platelet number and regulation of thrombopoiesis Hematol Am Soc Hematol Educ Program 2009 147 152
21. D.J. Kuter, and C.G. Begley Recombinant human thrombopoietin: Basic biology and evaluation of clinical studies Blood 100 2002 3457 3469 (Pubitemid 35303910)
22. T.R. Ulich, J. del Castillo, and S. Yin Megakaryocyte growth and development factor ameliorates carboplatin-induced thrombocytopenia in mice Blood 86 1995 971 976
23. K. Kaushansky, S. Lok, and R.D. Holly Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin Nature 369 1994 568 571 (Pubitemid 24192526)
24. J.E. Italiano Jr., and E.M. Battinelli Selective sorting of alpha-granule proteins J Thromb Haemost 7 Suppl 1 2009 173 176
25. M.A. Kowalska, L. Rauova, and M. Poncz The role of the platelet chemokine platelet factor 4 (PF4) in hemostasis and thrombosis Thromb Res 125 2010 292 296
26. J. Denton, D.A. Lane, and L. Thunberg Binding of platelet factor 4 to heparin oligosaccharides Biochem J 209 1983 455 460 (Pubitemid 13163719)
27. E.J. Houwerzijl, N.R. Blom, and J.J. van der Want Ultrastructural study shows morphologic features of apoptosis and para-apoptosis in megakaryocytes from patients with idiopathic thrombocytopenic purpura Blood 103 2004 500 506 (Pubitemid 38140080)
28. M. Delforge, V. Raets, and V. Van Duppen CD34+ marrow progenitors from MDS patients with high levels of intramedullary apoptosis have reduced expression of alpha4beta1 and alpha5beta1 integrins Leukemia 19 2005 57 63 (Pubitemid 40090077)
29. J.B. Bussel, D.J. Kuter, and V. Pullarkat Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP Blood 113 2009 2161 2171