Lower uncarboxylated osteocalcin concentrations in children with prediabetes is associated with β-cell function

Journal of Clinical Endocrinology and Metabolism

Volumn 96, Issue 7, 2011, Pages

  Pollock, Norman K ^a   Bernard, Paul J ^a   Gower, Barbara A ^b   Gundberg, Caren M ^c   Wenger, Karl ^a   Misra, Sudipta ^a   Bassali, Reda W ^a   Davis, Catherine L ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

25 HYDROXYVITAMIN D; AMINO TERMINAL TELOPEPTIDE; GLUCOSE; INSULIN; OSTEOCALCIN; PROCOLLAGEN C PROTEINASE;

AGE; ARTICLE; CARBOXYLATION; CELL FUNCTION; CHILD; CONTROLLED STUDY; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; MAJOR CLINICAL STUDY; MALE; NEGRO; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RACE DIFFERENCE; SCHOOL CHILD; SEX DIFFERENCE;

BLOOD GLUCOSE; CHILD; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; MALE; OSTEOCALCIN; PREDIABETIC STATE;

ANIMALIA;

EID: 79960090744     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2010-2731     Document Type: Article

References (36)

1. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, Dacquin R, Mee PJ, McKee MD, Jung DY, Zhang Z, Kim JK, Mauvais-Jarvis F, Ducy P, Karsenty G 2007 Endocrine regulation of energy metabolism by the skeleton. Cell 130:456-469 (Pubitemid 47208519)
2. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Myers Jr MG, Chua Jr SC, Kim JK, Kaestner KH, Karsenty G 2008 The sympathetic tone mediates leptin's inhibition of insulin secretion by modulating osteocalcin bioactivity. J Cell Biol 183:1235-1242
3. Ferron M, Hinoi E, Karsenty G, Ducy P 2008 Osteocalcin differentially regulates β cell and adipocyte gene expression and affects the development of metabolic diseases in wild-type mice. Proc Natl Acad Sci USA 105:5266-5270 (Pubitemid 351738545)
4. Fulzele K, Riddle RC, DiGirolamo DJ, Cao X, Wan C, Chen D, Faugere MC, Aja S, Hussain MA, Brüning JC, Clemens TL 2010 Insulin receptor signaling in osteoblasts regulates postnatal bone acquisition and body composition. Cell 142:309-319
5. Weinreb M, Shinar D, Rodan GA1990 Different pattern of alkaline phosphatase, osteopontin, and osteocalcin expression in developing rat bone visualized by in situ hybridization. J Bone Miner Res 5:831-842
6. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, Mellström D 2009 Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 24:785-791
7. Pittas AG, Harris SS, Eliades M, Stark P, Dawson-Hughes B 2009 Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab 94:827-832
8. Fernández-Real JM, Izquierdo M, Ortega F, Gorostiaga E, Gómez-Ambrosi J, Moreno-Navarrete JM, Frühbeck G, Martínez C, Idoate F, Salvador J, Forga L, Ricart W, Ibañez J 2009 The relationship of serum osteocalcin concentration to insulin secretion, sensitivity, and disposal with hypocaloric diet and resistance training. J Clin Endocrinol Metab 94:237-245
9. Kanazawa I, Yamaguchi T, Yamamoto M, Yamauchi M, Kurioka S, Yano S, Sugimoto T 2009 Serum osteocalcin level is associated with glucose metabolism and atherosclerosis parameters in type 2 diabetes mellitus. J Clin Endocrinol Metab 94:45-49
10. Reinehr T, Roth CL 2010 A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss. Int J Obes (Lond) 34:852-858
11. Prats-Puig A, Mas-Parareda M, Riera-Pérez E, González- Forcadell D, Mier C, Mallol-Guisset M, Díaz M, Bassols J, de Zegher F, Ibáñez L, López-Bermejo A 2010 Carboxylation of osteocalcin affects its association with metabolic parameters in healthy children. Diabetes Care 33:661-663
12. Shea MK, Gundberg CM, Meigs JB, Dallal GE, Saltzman E, Yoshida M, Jacques PF, Booth SL 2009 γ-Carboxylation of osteocalcin and insulin resistance in older men and women. Am J Clin Nutr 90: 1230-1235
13. Foresta C, Strapazzon G, DeToni L, Gianesello L, Calcagno A, Pilon C, Plebani M, Vettor R 2010 Evidence for osteocalcin production by adipose tissue and its role in human metabolism. J Clin Endocrinol Metab 95:3502-3506
14. Kanazawa I, Yamaguchi T, Yamauchi M, Yamamoto M, Kurioka S, Yano S, Sugimoto T 2011 Serum undercarboxylated osteocalcin was inversely associated with plasma glucose level and fat mass in type 2 diabetes mellitus. Osteoporos Int 22:187-194
15. Hwang YC, Jeong IK, Ahn KJ, Chung HY 2009 The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced β-cell function in middle-aged male subjects. Diabetes Metab Res Rev 25:768-772
16. Davis CL, Tomporowski PD, McDowell JE, Austin BP, Miller PH, Yanasak NE, Allison JD, Naglieri JA 2011 Exercise improves executive function and achievement and alters brain activation in overweight children: a randomized, controlled trial. Health Psychol 30: 91-98
17. Ogden CL, Kuczmarski RJ, Flegal KM, Mei Z, Guo S, Wei R, Grummer- Strawn LM, Curtin LR, Roche AF, Johnson CL 2002 Centers for Disease Control and Prevention 2000 growth charts for the United States: improvements to the 1977 National Center for Health Statistics version. Pediatrics 109:45-60
18. Goran MI, Gower BA 2001 Longitudinal study on pubertal insulin resistance. Diabetes 50:2444-2450 (Pubitemid 33642760)
19. Pollock NK, Bernard PJ, Wenger K, Misra S, Gower BA, Allison JD, Zhu H, Davis CL 2010 Lower bone mass in prepubertal overweight children with prediabetes. J Bone Miner Res 25:2484-2493
20. Gundberg CM, Nieman SD, Abrams S, Rosen H 1998 Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83:3258-3266
21. Matsuda M, DeFronzo RA 1999 Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care 22:1462-1470 (Pubitemid 29418240)
22. Hanson RL, Pratley RE, Bogardus C, Narayan KM, Roumain JM, Imperatore G, Fagot-Campagna A, Pettitt DJ, Bennett PH, Knowler WC 2000 Evaluation of simple indices of insulin sensitivity and insulin secretion for use in epidemiologic studies. Am J Epidemiol 151:190-198 (Pubitemid 30463650)
23. Abdul-Ghani MA, Williams K, DeFronzo RA, Stern M 2007 What is the best predictor of future type 2 diabetes? Diabetes Care 30: 1544-1548
24. Owens S, Gutin B, Allison J, Riggs S, Ferguson M, Litaker M, Thompson W 1999 Effect of physical training on total and visceral fat in obese children. Med Sci Sports Exerc 31:143-148 (Pubitemid 29036371)
25. Centers for Disease Control and Prevention 2004 Methodology of the youth risk behavior surveillance system.MMWRMorb Mortal Wkly Rep 53:1-13
26. Brener ND, Collins JL, Kann L, Warren CW, Williams BI 1995 Reliability of the Youth Risk Behavior Survey Questionnaire. Am J Epidemiol 141:575-580
27. American Diabetes Association 2008 Diagnosis and classification of diabetes mellitus. Diabetes Care 31(Suppl 1):S55-S60
28. Goran MI, Gower BA 1999 Relation between visceral fat and disease risk in children and adolescents. Am J Clin Nutr 70:149S-156S
29. Gundberg CM 2009 Vitamin K and bone: past, present, and future. J Bone Miner Res 24:980-982
30. Camacho P, Kleerekoper M 2006 Biochemical markers of bone turnover. In: Favus MJ, ed. Primer on the metabolic bone diseases and disorders of mineral metabolism. 6th ed. Washington, DC: American Society of Bone and Mineral Research; 127-133
31. Ferron M, Wei J, Yoshizawa T, Del Fattore A, DePinho RA, Teti A, Ducy P, Karsenty G 2010 Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism. Cell 142:296-308
32. Hinoi E, Gao N, Jung DY, Yadav V, Yoshizawa T, Kajimura D, Myers JrMG, Chua Jr SC, Wang Q, Kim JK, Kaestner KH, Karsenty G 2009 An osteoblast-dependent mechanism contributes to the leptin regulation of insulin secretion. Ann NY Acad Sci 1173(Suppl 1):E20-E30
33. Food and Nutrition Board, Institute of Medicine 2001 Dietary reference intakes for vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. Washington, DC: National Academy Press; 162-196
34. Booth SL, Lichtenstein AH, O'Brien-Morse M, McKeown NM, Wood RJ, Saltzman E, Gundberg CM 2001 Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 74:783-790 (Pubitemid 33101799)
35. Yoshida M, Jacques PF, Meigs JB, Saltzman E, Shea MK, Gundberg C, Dawson-Hughes B, Dallal G, Booth SL 2008 Effect of vitamin K supplementation on insulin resistance in older men and women. Diabetes Care 31:2092-2096
36. Beulens JW, van der A DL, Grobbee DE, Sluijs I, Spijkerman AM, van der Schouw YT 2010 Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care 33:1699-1705