-
1
-
-
0025766610
-
Von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation
-
Fay PJ, et al. von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation. J Biol Chem 1991; 266: 2172-2177.
-
(1991)
J Biol Chem
, vol.266
, pp. 2172-2177
-
-
Fay, P.J.1
-
2
-
-
1842408993
-
Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII)
-
Pittman DD, Kaufman RJ. Proteolytic requirements for thrombin activation of anti-hemophilic factor (factor VIII). Proc Natl Acad Sci USA 1988; 85: 2429-2433.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 2429-2433
-
-
Pittman, D.D.1
Kaufman, R.J.2
-
3
-
-
0019831499
-
The role of phospholipid and factor VIIIa in the activation of bovine factor X
-
van Dieijen G, et al. The role of phospholipid and factor VIIIa in the activation of bovine factor X. J Biol Chem 1981; 256: 3433-3442.
-
(1981)
J Biol Chem
, vol.256
, pp. 3433-3442
-
-
van Dieijen, G.1
-
4
-
-
0021750055
-
Characterization of the human factor VIII gene
-
Gitschier J, et al. Characterization of the human factor VIII gene. Nature 1984; 312: 326-330.
-
(1984)
Nature
, vol.312
, pp. 326-330
-
-
Gitschier, J.1
-
5
-
-
0021715169
-
Molecular cloning of a cDNA encoding human antihaemophilic factor
-
Toole JJ, et al. Molecular cloning of a cDNA encoding human antihaemophilic factor. Nature 1984; 312: 342-347.
-
(1984)
Nature
, vol.312
, pp. 342-347
-
-
Toole, J.J.1
-
6
-
-
41449117525
-
Crystal structure of human factor VIII: Implications for the formation of the factor IXa-factor VIIIa complex
-
Ngo JC, et al. Crystal structure of human factor VIII: implications for the formation of the factor IXa-factor VIIIa complex. Structure 2008; 16: 597-606.
-
(2008)
Structure
, vol.16
, pp. 597-606
-
-
Ngo, J.C.1
-
7
-
-
0033604501
-
Structure of the C2 domain of human factor VIII at 1.5 A resolution
-
Pratt KP, et al. Structure of the C2 domain of human factor VIII at 1.5 A resolution. Nature 1999; 402: 439-442.
-
(1999)
Nature
, vol.402
, pp. 439-442
-
-
Pratt, K.P.1
-
8
-
-
38949168866
-
The tertiary structure and domain organization of coagulation factor VIII
-
Shen BW, et al. The tertiary structure and domain organization of coagulation factor VIII. Blood 2008; 111: 1240-1247.
-
(2008)
Blood
, vol.111
, pp. 1240-1247
-
-
Shen, B.W.1
-
9
-
-
0025297357
-
Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine
-
Foster PA, et al. Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine. Blood 1990; 75: 1999-2004.
-
(1990)
Blood
, vol.75
, pp. 1999-2004
-
-
Foster, P.A.1
-
10
-
-
0029032377
-
A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor
-
Saenko EL, Scandella D. A mechanism for inhibition of factor VIII binding to phospholipid by von Willebrand factor. J Biol Chem 1995; 270: 13826-13833.
-
(1995)
J Biol Chem
, vol.270
, pp. 13826-13833
-
-
Saenko, E.L.1
Scandella, D.2
-
11
-
-
0033056797
-
Mapping of the minimal domain encoding a conformational epitope by lambda phage surface display: Factor VIII inhibitor antibodies from haemophilia A patients
-
Kuwabara I, et al. Mapping of the minimal domain encoding a conformational epitope by lambda phage surface display: factor VIII inhibitor antibodies from haemophilia A patients. J Immunol Methods 1999; 224: 89-99.
-
(1999)
J Immunol Methods
, vol.224
, pp. 89-99
-
-
Kuwabara, I.1
-
12
-
-
0031856491
-
Factor VIII inhibitors in mild and moderate-severity haemophilia A
-
Hay CR. Factor VIII inhibitors in mild and moderate-severity haemophilia A. Haemophilia 1998; 4: 558-563.
-
(1998)
Haemophilia
, vol.4
, pp. 558-563
-
-
Hay, C.R.1
-
13
-
-
27744489219
-
High-throughput site-directed mutagenesis using oligonucleotides synthesized on DNA chips
-
Saboulard D, et al. High-throughput site-directed mutagenesis using oligonucleotides synthesized on DNA chips. Biotechniques 2005; 39: 363-368.
-
(2005)
Biotechniques
, vol.39
, pp. 363-368
-
-
Saboulard, D.1
-
14
-
-
0037877123
-
A system for X-ray crystallography and NMR
-
Yale University Press, New Haven, (CT) X-PLOR Version 3
-
Brünger AT. X-PLOR, version 3.1. A system for X-ray crystallography and NMR. Yale University Press, New Haven, (CT); 1992.
-
(1992)
, vol.1
-
-
Brünger, A.T.1
-
15
-
-
0041784950
-
All-atom empirical potential for molecular modeling and dynamics studies of proteins
-
MacKerell AD, et al. All-atom empirical potential for molecular modeling and dynamics studies of proteins. J Phys Chem B 1998; 102: 3586-3616.
-
(1998)
J Phys Chem B
, vol.102
, pp. 3586-3616
-
-
Mackerell, A.D.1
-
16
-
-
33748282179
-
Multi-template approach to modeling engineered disulfide bonds
-
Pellequer J-L, Chen S-W. Multi-template approach to modeling engineered disulfide bonds. Proteins 2006; 65: 192-202.
-
(2006)
Proteins
, vol.65
, pp. 192-202
-
-
Pellequer, J.-L.1
Chen, S-W.2
-
17
-
-
1642387872
-
Identification of functionally important residues in proteins using comparative models
-
Chen S-WW, Pellequer JL. Identification of functionally important residues in proteins using comparative models. Curr Med Chem 2004; 11: 595-605.
-
(2004)
Curr Med Chem
, vol.11
, pp. 595-605
-
-
Chen, S.-W.W.1
Pellequer, J.L.2
-
18
-
-
0027656984
-
PREDITOP: A program for antigenicity predictions
-
Pellequer JL, Westhof E. PREDITOP: a program for antigenicity predictions. J Mol Graph 1993; 11: 204-210.
-
(1993)
J Mol Graph
, vol.11
, pp. 204-210
-
-
Pellequer, J.L.1
Westhof, E.2
-
19
-
-
0037263777
-
BEPITOPE: Predicting the location of continuous epitopes and patterns in proteins
-
Odorico M, Pellequer J-L. BEPITOPE: predicting the location of continuous epitopes and patterns in proteins. J Mol Recognit 2003; 16: 20-22.
-
(2003)
J Mol Recognit
, vol.16
, pp. 20-22
-
-
Odorico, M.1
Pellequer, J.-L.2
-
20
-
-
0032467348
-
Homology models of the C domains of blood coagulation factors V and VIII: A proposed membrane binding mode for FV and FVIII C2 domains
-
Pellequer JL, et al. Homology models of the C domains of blood coagulation factors V and VIII: a proposed membrane binding mode for FV and FVIII C2 domains. Blood Cells Mol Dis 1998; 24: 448-461.
-
(1998)
Blood Cells Mol Dis
, vol.24
, pp. 448-461
-
-
Pellequer, J.L.1
-
21
-
-
39649102400
-
Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation
-
Meeks SL, et al. Antihuman factor VIII C2 domain antibodies in hemophilia A mice recognize a functionally complex continuous spectrum of epitopes dominated by inhibitors of factor VIII activation. Blood 2007; 110: 4234-4242.
-
(2007)
Blood
, vol.110
, pp. 4234-4242
-
-
Meeks, S.L.1
-
22
-
-
0027411150
-
Alanine-scanning mutagenesis of the epidermal growth factor- like domains of human thrombomodulin identifies critical residues for its cofactor activity
-
Nagashima M, et al. Alanine-scanning mutagenesis of the epidermal growth factor- like domains of human thrombomodulin identifies critical residues for its cofactor activity. J Biol Chem 1993; 268: 2888-2892.
-
(1993)
J Biol Chem
, vol.268
, pp. 2888-2892
-
-
Nagashima, M.1
-
23
-
-
77951020704
-
Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII
-
Dimitrov JD, et al. Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII. Blood 2010; 115: 2682-2685.
-
(2010)
Blood
, vol.115
, pp. 2682-2685
-
-
Dimitrov, J.D.1
-
24
-
-
11144226932
-
Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities
-
Spiegel PC, et al. Surface-exposed hemophilic mutations across the factor VIII C2 domain have variable effects on stability and binding activities. J Biol Chem 2004; 279: 53691-53698.
-
(2004)
J Biol Chem
, vol.279
, pp. 53691-53698
-
-
Spiegel, P.C.1
-
25
-
-
0037846480
-
Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding
-
Lewis DA, et al. Contributions of Asn2198, Met2199, and Phe2200 in the factor VIII C2 domain to cofactor activity, phospholipid-binding, and von Willebrand factor-binding. Thromb Haemost 2003; 89: 795-802.
-
(2003)
Thromb Haemost
, vol.89
, pp. 795-802
-
-
Lewis, D.A.1
-
26
-
-
0029840409
-
Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins
-
Pipe SW, Kaufman RJ. Factor VIII C2 domain missense mutations exhibit defective trafficking of biologically functional proteins. J Biol Chem 1996; 271: 25671-25676.
-
(1996)
J Biol Chem
, vol.271
, pp. 25671-25676
-
-
Pipe, S.1
Kaufman, R.2
-
27
-
-
2942522566
-
Mutation of the surface-exposed amino acid Trp to Ala in the FVIII C2 domain results in defective secretion of the otherwise functional protein
-
Schatz SM, et al. Mutation of the surface-exposed amino acid Trp to Ala in the FVIII C2 domain results in defective secretion of the otherwise functional protein. Br J Haematol 2004; 125: 629-637.
-
(2004)
Br J Haematol
, vol.125
, pp. 629-637
-
-
Schatz, S.M.1
-
28
-
-
0037155149
-
Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs
-
Gilbert GE, et al. Four hydrophobic amino acids of the factor VIII C2 domain are constituents of both the membrane-binding and von Willebrand factor-binding motifs. J Biol Chem 2002; 277: 6374-6381.
-
(2002)
J Biol Chem
, vol.277
, pp. 6374-6381
-
-
Gilbert, G.E.1
-
29
-
-
34548796475
-
The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene
-
Chen L, et al. The enhancing effects of the light chain on heavy chain secretion in split delivery of factor VIII gene. Mol Ther 2007; 15: 1856-1862.
-
(2007)
Mol Ther
, vol.15
, pp. 1856-1862
-
-
Chen, L.1
-
30
-
-
0030446531
-
Enhanced secretory ability for the human factor VIII light chain produced in baculovirus-infected insect cells
-
Webb E, et al. Enhanced secretory ability for the human factor VIII light chain produced in baculovirus-infected insect cells. Cytotechnology 1996; 21: 165-170.
-
(1996)
Cytotechnology
, vol.21
, pp. 165-170
-
-
Webb, E.1
-
31
-
-
0038291903
-
The preparation and phospholipid binding property of the C2 domain of human factor VIII
-
Takeshima K, et al. The preparation and phospholipid binding property of the C2 domain of human factor VIII. Thromb Haemost 2003; 89: 788-794.
-
(2003)
Thromb Haemost
, vol.89
, pp. 788-794
-
-
Takeshima, K.1
-
32
-
-
0032533220
-
Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII
-
Healey JF, et al. Residues Glu2181-Val2243 contain a major determinant of the inhibitory epitope in the C2 domain of human factor VIII. Blood 1998; 92: 3701-3709.
-
(1998)
Blood
, vol.92
, pp. 3701-3709
-
-
Healey, J.F.1
-
33
-
-
0029154988
-
Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site
-
Scandella D, et al. Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site. Blood 1995; 86: 1811-1819.
-
(1995)
Blood
, vol.86
, pp. 1811-1819
-
-
Scandella, D.1
-
34
-
-
0027457180
-
A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine
-
Shima M, et al. A factor VIII neutralizing monoclonal antibody and a human inhibitor alloantibody recognizing epitopes in the C2 domain inhibit factor VIII binding to von Willebrand factor and to phosphatidylserine. Thromb Haemost 1993; 69: 240-246.
-
(1993)
Thromb Haemost
, vol.69
, pp. 240-246
-
-
Shima, M.1
-
35
-
-
34547523962
-
Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain
-
Nogami K, et al. Relationship between the binding sites for von Willebrand factor, phospholipid, and human factor VIII C2 inhibitor alloantibodies within the factor VIII C2 domain. Int J Hematol 2007; 85: 317-322.
-
(2007)
Int J Hematol
, vol.85
, pp. 317-322
-
-
Nogami, K.1
-
36
-
-
0037709840
-
Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding
-
Lewis DA, et al. Binding of factor VIII inhibitors to discrete regions of the factor VIII C2 domain disrupt phospholipid binding. Blood Coagul Fibrinolysis 2003; 14: 361-368.
-
(2003)
Blood Coagul Fibrinolysis
, vol.14
, pp. 361-368
-
-
Lewis, D.A.1
-
37
-
-
9144271163
-
Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development
-
d'Oiron R, et al. Deletion of alanine 2201 in the FVIII C2 domain results in mild hemophilia A by impairing FVIII binding to VWF and phospholipids and destroys a major FVIII antigenic determinant involved in inhibitor development. Blood 2004; 103: 155-157.
-
(2004)
Blood
, vol.103
, pp. 155-157
-
-
D'Oiron, R.1
-
38
-
-
77950576377
-
Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: Structure of a complex between the C2 domain and an inhibitor of membrane binding
-
Liu Z, et al. Trp2313-His2315 of factor VIII C2 domain is involved in membrane binding: structure of a complex between the C2 domain and an inhibitor of membrane binding. J Biol Chem 2010; 285: 8824-8829.
-
(2010)
J Biol Chem
, vol.285
, pp. 8824-8829
-
-
Liu, Z.1
-
39
-
-
0033956822
-
Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII
-
Gale AJ, et al. Structural basis for hemophilia A caused by mutations in the C domains of blood coagulation factor VIII. Thromb Haemost 2000; 83: 78-85.
-
(2000)
Thromb Haemost
, vol.83
, pp. 78-85
-
-
Gale, A.J.1
-
40
-
-
18844416634
-
Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII
-
Lewis DA, et al. Phospholipid vesicles interfere with the binding of antibody fragments to the light chain of factor VIII. Thromb Haemost 2005; 93: 833-841.
-
(2005)
Thromb Haemost
, vol.93
, pp. 833-841
-
-
Lewis, D.A.1
-
41
-
-
0032728689
-
Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: Requirement of Cys2326 and Glu2327 for maximum effect
-
Nogami K, et al. Identification of a factor VIII peptide, residues 2315-2330, which neutralizes human factor VIII C2 inhibitor alloantibodies: requirement of Cys2326 and Glu2327 for maximum effect. Br J Haematol 1999; 107: 196-203.
-
(1999)
Br J Haematol
, vol.107
, pp. 196-203
-
-
Nogami, K.1
-
42
-
-
0035412387
-
Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: Identification of an inhibitory antibody epitope on the surface of factor VIII
-
Spiegel PC, Jr., et al. Structure of a factor VIII C2 domain-immunoglobulin G4kappa Fab complex: identification of an inhibitory antibody epitope on the surface of factor VIII. Blood 2001; 98: 13-19.
-
(2001)
Blood
, vol.98
, pp. 13-19
-
-
Spiegel Jr., P.C.1
-
43
-
-
3242716186
-
Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope
-
Parker ET, et al. Reduction of the inhibitory antibody response to human factor VIII in hemophilia A mice by mutagenesis of the A2 domain B-cell epitope. Blood 2004; 104: 704-710.
-
(2004)
Blood
, vol.104
, pp. 704-710
-
-
Parker, E.T.1
-
44
-
-
0030815133
-
Raster3D: Photorealistic molecular graphics
-
Merritt EA, Bacon DJ. Raster3D: Photorealistic molecular graphics. Meth Enzymol 1997; 277: 505-524.
-
(1997)
Meth Enzymol
, vol.277
, pp. 505-524
-
-
Merritt, E.A.1
Bacon, D.J.2
-
45
-
-
0029878720
-
VMD: Visual molecular dynamics
-
Humphrey W, et al. VMD: visual molecular dynamics. J Mol Graph 1996; 14: 33-38.
-
(1996)
J Mol Graph
, vol.14
, pp. 33-38
-
-
Humphrey, W.1
-
46
-
-
65649123444
-
Structure-activity relationships in peptide-antibody complexes: Implications for epitope prediction and development of synthetic peptide vaccines
-
Chen S-wW, et al. Structure-activity relationships in peptide-antibody complexes: implications for epitope prediction and development of synthetic peptide vaccines. Curr Med Chem 2009; 16: 953-964.
-
(2009)
Curr Med Chem
, vol.16
, pp. 953-964
-
-
Chen, S.-W.W.1
-
47
-
-
0029619259
-
Knowledge-based protein secondary structure assignment
-
Frishman D, Argos P. Knowledge-based protein secondary structure assignment. Proteins 1995; 23: 566-579.
-
(1995)
Proteins
, vol.23
, pp. 566-579
-
-
Frishman, D.1
Argos, P.2
|