HIV-1 Nef impairs multiple T-cell functions in antigen-specific immune response in mice

International Immunology

Volumn 23, Issue 7, 2011, Pages 433-441

  Fujii, Hideki ^a,b   Ato, Manabu ^b   Takahashi, Yoshimasa ^b   Otake, Kaori ^c   Hashimoto, Shu ichi ^d   Kaji, Tomohiro ^e   Tsunetsugu yokota, Yasuko ^b   Fujita, Mikako ^f   Adachi, Akio ^g   Nakayama, Toshinori ^h   Taniguchi, Masaru ^e   Koyasu, Shigeo ^a   Takemori, Toshitada ^b,e  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b NATIONAL INSTITUTE OF INFECTIOUS DISEASES   (Japan)

^c Gifu Social Insurance Hospital   (Japan)

^d Chiome Bioscience Inc   (Japan)

^e Institute of Physical and Chemical Research   (Japan)

^f KUMAMOTO UNIVERSITY   (Japan)

^g UNIVERSITY OF TOKUSHIMA   (Japan)

^h CHIBA UNIVERSITY   (Japan)

Author keywords

Acquired immunity; AIDS; Humoral response

Indexed keywords

NEF PROTEIN; OVALBUMIN; VIRUS PROTEIN;

ANIMAL MODEL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE ACTIVATION; CD4+ T LYMPHOCYTE; CELL MIGRATION; CYTOKINE PRODUCTION; CYTOPATHOGENIC EFFECT; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNE RESPONSE; IMMUNITY; IN VIVO STUDY; LYMPHOCYTE PROLIFERATION; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; VIRUS REPLICATION;

EID: 79960052377     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxr031     Document Type: Article

References (32)

1. Fackler, O. T. and Baur, A. S. 2002. Live and let die: Nef functions beyond HIV replication. Immunity 16:493.
2. Wang, J. K., Kiyokawa, E., Verdin, E. and Trono, D. 2000. The Nef protein of HIV-1 associates with rafts and primes T cells for activation. Proc. Natl Acad. Sci. USA 97:394.
3. Simmons, A., Aluvihare, V. and McMichael, A. 2001. Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators. Immunity 14:763.
4. Manninen, A. and Saksela, K. 2002. HIV-1 Nef interacts with inositol trisphosphate receptor to activate calcium signaling in T cells. J. Exp. Med. 195:1023.
5. + T cells requires Nef and Tat virus gene products and results from higher NFAT, NF-jB, and AP-1 induction. J. Biol. Chem. 279:39520.
6. Campbell, D. J., Kim, C. H. and Butcher, E. C. 2003. Chemokines in the systemic organization of immunity. Immunol. Rev. 195:58.
7. Janardhan, A., Swigut, T., Hill, B., Myers, M. P. and Skowronski, J. 2004. HIV-1 Nef binds the DOCK2-ELMO1 complex to activate rac and inhibit lymphocyte chemotaxis. PLoS Biol. 2:E6.
8. Hanna, Z., Kay, D. G., Rebai, N., Guimond, A., Jothy, S. and Jolicoeur, P. 1998. Nef harbors a major determinant of pathogenicity for an AIDS-like disease induced by HIV-1 in transgenic mice. Cell 95:163.
9. + T-cell activation is Nef dependent and can occur in the absence of lymphophenia. J. Virol. 83:11830.
10. Koenen, P. G., Hofhuis, F. M., Oosterwegel, M. A. and Tesselaar, K. 2007. T cell activation and proliferation characteristic for HIV-Nef transgenic mice is lymphopenia induced. J. Immunol. 178:5762.
11. Wan, Y. Y., Leon, R. P., Marks, R. et al. 2000. Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc. Natl Acad. Sci. USA 97:13784.
12. lo thymocytes in vivo. Science 250:1720.
13. Kanegae, Y., Makimura, M. and Saito, I. 1994. A simple and efficient method for purification of infectious recombinant adenovirus. Jpn. J. Med. Sci. Biol. 47:157.
14. Takahashi, Y., Ohta, H. and Takemori, T. 2001. Fas is required for clonal selection in germinal centers and the subsequent establishment of the memory B cell repertoire. Immunity 14:181.
15. Choe, E. Y., Schoenberger, E. S., Groopman, J. E. and Park, I. W. 2002. HIV Nef inhibits T cell migration. J. Biol. Chem. 277:46079.
16. Marrack, P. and Kappler, J. 2004. Control of T cell viability. Annu. Rev. Immunol. 22:765.
17. + T cells. Proc. Natl Acad. Sci. USA 98:9277.
18. Craig, H. M., Pandori, M. W. and Guatelli, J. C. 1998. Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity. Proc. Natl Acad. Sci. USA 95:11229.
19. Dubey, S., Khalid, M., Wesley, C., Khan, S. A., Wanchu, A. and Jameel, S. 2008. Downregulation of CCR5 on activated CD4 T cells in HIV-infected Indians. J. Clin. Virol. 43:25.
20. Venzke, S., Michel, N., Allespach, I., Fackler, O. T. and Keppler, O. T. 2006. Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection. J. Virol. 80:11141.
21. Zajac, A. J., Blattman, J. N., Murali-Krishna, K. et al. 1998. Viral immune evasion due to persistence of activated T cells without effector function. J Exp Med. 188:2205.
22. Zhang, J. et al. 2000. Regulation of fas ligand expression during activation-induced cell death in T cells by p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase. J. Exp. Med. 191:1017.
23. Rhee, S. S. and Marsh, J. W. 1994. HIV-1 Nef activity in murine T cells. CD4 modulation and positive enhancement. J. Immunol. 152:5128.
24. Priceputu, E., Hanna, Z., Hu, C. et al. 2007. Primary human immunodeficiency virus type 1 nef alleles show major differences in pathogenicity in transgenic mice. J. Virol. 81:4677.
25. Bunnell, S. C., Hong, D. I., Kardon, J. R. et al. 2002. T cell receptor ligation induces the formation of dynamically regulated signaling assemblies. J. Cell Biol. 158:1263.
26. Dustin, M. L. 2009. The cellular context of T cell signaling. Immunity. 30:482.
27. Thoulouze, M. I., Sol-Foulon, N., Blanchet, F., Dautry-Varsat, A., Schwartz, O. and Alcover, A. 2006. Human immunodeficiency virus type-1 infection impairs the formation of the immunological synapse. Immunity 24:547.
28. Pereira, J. P., Kelly, L. M. and Cyster, J. G. 2010. Finding the right niche: B-cell migration in the early phases of T-dependent antibody responses. Int. Immunol. 22:413.
29. Veillette, A., Bookman, M. A., Horak, E. M., Samelson, L. E. and Bolen, J. B. 1989. Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature 338:257.
30. Krummel, M. F., Sjaastad, M. D., Wulfing, C. and Davis, M. M. 2000. Differential clustering of CD4 and CD3f during T cell recognition. Science 289:1349.
31. Holdorf, A. D., Lee, K. H., Burack, W. R., Allen, P. M. and Shaw, A. S. 2002. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat. Immunol. 3:259.
32. Stevenson, M. 2003. HIV-1 pathogenesis. Nat. Med. 9:853.