Prostanoid DP receptor antagonists suppress symptomatic asthma-like manifestation by distinct actions from a glucocorticoid in rats

European Journal of Pharmacology

Volumn 666, Issue 1-3, 2011, Pages 233-241

  Hirano, Yosuke ^a   Shichijo, Michitaka ^a   Ikeda, Minoru ^a   Kitaura, Motoji ^a   Tsuchida, Junji ^a   Asanuma, Fujio ^a   Yanagimoto, Toru ^a   Furue, Yoko ^a   Imura, Kinichi ^a   Yasui, Kiyoshi ^a   Arimura, Akinori ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

Asthma; Glucocorticoid; Neutrophil; Prostaglandin D2; Prostanoid DP receptor antagonist

Indexed keywords

7 [2 (5 HYDROXYBENZO[B]THIOPEN 3 YLCARBONYLAMINO) 10 NORPINAN 3 YL] HEPT 5 ENOIC ACID; ANTIASTHMATIC AGENT; CXCL1 CHEMOKINE; EOTAXIN; INTERLEUKIN 1BETA; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PINAGLADIN; PREDNISOLONE; PROSTANOID DP RECEPTOR ANTAGONIST; S 5751; UNCLASSIFIED DRUG;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CELL INFILTRATION; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG MECHANISM; EOSINOPHIL; FEMALE; HUMAN; HUMAN TISSUE; LOEFFLER PNEUMONIA; LUNG LAVAGE; MACROPHAGE; MALE; MONOCYTE; MUCUS SECRETION; NEUTROPHILIA; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIZATION; SYMPTOMATOLOGY;

ACETYLCHOLINE; AGED; ANIMALS; ANTIGENS; ASTHMA; BRONCHIAL HYPERREACTIVITY; CHEMOKINES; FEMALE; GENE EXPRESSION REGULATION; GLUCOCORTICOIDS; HUMANS; LUNG; MALE; MUCUS; NEUTROPHIL INFILTRATION; PREDNISOLONE; PROTEIN TRANSPORT; RATS; RECEPTORS, IMMUNOLOGIC; RECEPTORS, PROSTAGLANDIN; RNA, MESSENGER; THIOPHENES; YOUNG ADULT;

EID: 79960028737     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.003     Document Type: Article

References (32)

1. L. Antonicelli, C. Bucca, M. Neri, F. De Benedetto, P. Sabbatani, F. Bonifazi, H.G. Eichler, Q. Zhang, and D.D. Yin Asthma severity and medical resource utilization Eur. Respir. J. 23 2004 723 729 (Pubitemid 38618143)
2. M. Aoki, M. Fukunaga, M. Kitagawa, K. Hayashi, T. Morokata, G. Ishikawa, S. Kubo, and T. Yamada Effect of novel anti-inflammatory compound, YM976, on antigen-induced eosinophil infiltration into the lung in rats, mice, and ferrets J. Pharmacol. Exp. Ther. 295 2000 1149 1155
3. A. Arimura, F. Asanuma, Y. Matsumoto, A. Kurosawa, H. Jyoyama, and H. Nagai Effect of the selective thromboxane A2 receptor antagonist, S-1452, on antigen-induced sustained bronchial hyperresponsiveness Eur. J. Pharmacol. 260 1994 201 209 (Pubitemid 24240022)
4. A. Arimura, K. Yasui, J. Kishino, F. Asanuma, H. Hasegawa, S. Kakudo, M. Ohtani, and H. Arita Prevention of allergic inflammation by a novel prostaglandin receptor antagonist, S-5751 J. Pharmacol. Exp. Ther. 298 2001 411 419 (Pubitemid 32673391)
5. P.J. Barnes Effect of corticosteroids on airway hyperresponsiveness Am. Rev. Respir. Dis. 141 1990 S70 S76
6. P.J. Barnes, and A.J. Woolcock Difficult asthma Eur. Respir. J. 12 1998 1209 1218 (Pubitemid 28545638)
7. I. Basyigit, F. Yildiz, S.K. Ozkara, H. Boyaci, and A. Ilgazli Inhaled corticosteroid effects both eosinophilic and non-eosinophilic inflammation in asthmatic patients Mediators Inflamm. 13 2004 285 291 (Pubitemid 39573537)
8. R.G. Bhagat, and M.M. Grunstein Effect of corticosteroids on bronchial responsiveness to methacholine in asthmatic children Am. Rev. Respir. Dis. 131 1985 902 906 (Pubitemid 15065923)
9. D.H. Broide, M. Lotz, A.J. Cuomo, D.A. Coburn, E.C. Federman, and S.I. Wasserman Cytokines in symptomatic asthma airways J. Allergy Clin. Immunol. 89 1992 958 967
10. A. Doganci, T. Eigenbrod, N. Krug, G.T. De Sanctis, M. Hausding, V.J. Erpenbeck, el-B. Haddad, H.A. Lehr, E. Schmitt, T. Bopp, K.J. Kallen, U. Herz, S. Schmitt, C. Luft, O. Hecht, J.M. Hohlfeld, H. Ito, N. Nishimoto, K. Yoshizaki, T. Kishimoto, S. Rose-John, H. Renz, M.F. Neurath, P.R. Galle, and S. Finotto The IL-6R alpha chain controls lung CD4 + CD25+ Treg development and function during allergic airway inflammation in vivo J. Clin. Invest. 115 2005 313 325 (Pubitemid 40385473)
11. F.G. Gervais, R.P. Cruz, B.A. Chateauneuf, S. Gale, N. Sawyer, F. Nantel, K.M. Metters, and G.P. O'Neill Selective modulation of chemokinesis, degranulation, and apoptosis in eosinophils through the PGD2 receptors CRTH2 and DP J. Allergy Clin. Immunol. 108 2001 983 988
12. H. Hirai, K. Tanaka, O. Yoshie, K. Ogawa, K. Kenmotsu, Y. Takamori, M. Ichimasa, K. Sugamura, M. Nakamura, S. Takano, and K. Nagata Prostaglandin D2 selectively induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2 J. Exp. Med. 193 2001 255 261 (Pubitemid 32524457)
13. A. Jatakanon, C. Uasuf, W. Maziak, S. Lim, K.F. Chung, and P.J. Barnes Neutrophilic inflammation in severe persistent asthma Am. J. Respir. Crit. Care Med. 160 1999 1532 1539
14. S. Konno, Y. Gonokami, M. Kurokawa, K. Kawazu, K. Asano, K. Okamoto, and M. Adachi Cytokine concentrations in sputum of asthmatic patients Int. Arch. Allergy Immunol. 109 1996 73 78
15. C. Lamblin, P. Gosset, I. Tillie-Leblond, F. Saulnier, C.H. Marquette, B. Wallaert, and A.B. Tonnel Bronchial neutrophilia in patients with noninfectious status asthmaticus Am. J. Respir. Crit. Care Med. 157 1998 394 402 (Pubitemid 28090526)
16. H.Y. Lan, W. Mu, Y.Y. NG, D.J. Nikolic-Paterson, and R.C. Atkins A simple, reliable, and sensitive method for nonradioactive in situ hybridization: use of microwave heating to improve hybridization efficiency and preserve tissue morphology J. Histochem. Cytochem. 44 1996 281 287 (Pubitemid 26081129)
17. U. Lappalainen, J.A. Whitsett, S.E. Wert, J.W. Tichelaar, and K. Bry Interleukin-1beta causes pulmonary inflammation, emphysema, and airway remodeling in the adult murine lung Am. J. Respir. Cell Mol. Biol. 32 2005 311 318 (Pubitemid 40478306)
18. R.A. Lewis, N.A. Soter, P.T. Diamond, K.F. Austen, J.A. Oates, and L.J. Roberts II Prostaglandin D2 generation after the activation of rat and human mast cells with anti-IgE J. Immunol. 129 1982 1627 1631 (Pubitemid 12031103)
19. S.A. Little, K.J. MacLeod, G.W. Chalmers, J.G. Love, C. McSharry, and N.C. Thomson Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma Am. J. Med. 112 2002 446 452 (Pubitemid 34450704)
20. M.C. Liu, W.C. Hubbard, D. Proud, B.A. Stealey, S.J. Galli, A. Kagey-Sobotka, E.R. Bleecker, and L.M. Lichtenstein Immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. Cellular, mediator, and permeability changes. Am. Rev. Respir. Dis. 144 1991 51 58
21. M.C. Liu, D. Proud, L.M. Lichtenstein, W.C. Hubbard, B.S. Bochner, B.A. Stealey, L. Breslin, H. Xiao, L.R. Freidhoff, J.T. Schroeder, and R.P. Schleimer Effects of prednisone on the cellular responses and release of cytokines and mediators after segmental allergen challenge of asthmatic subjects J. Allergy Clin. Immunol. 108 2001 29 38 (Pubitemid 32662229)
22. T. Matsuoka, M. Hirata, H. Tanaka, Y. Takahashi, T. Murata, K. Kabashima, Y. Sugimoto, T. Kobayashi, F. Ushikubi, Y. Aze, N. Eguchi, Y. Urade, N. Yoshida, K. Kimura, A. Mizoguchi, Y. Honda, H. Nagai, and S. Narumiya Prostaglandin D2 as a mediator of allergic asthma Science 287 2000 2013 2017
23. L.C. Meagher, J.M. Cousin, J.R. Seckl, and C. Haslett Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes J. Immunol. 156 1996 4422 4428 (Pubitemid 26165843)
24. S. Mitsumori, T. Tsuri, T. Honma, Y. Hiramatsu, T. Okada, H. Hashizume, S. Kida, M. Inagaki, A. Arimura, K. Yasui, F. Asanuma, J. Kishino, and M. Ohtani Synthesis and biological activity of various derivatives of a novel class of potent, selective, and orally active prostaglandin D2 receptor antagonists. 2. 6,6-Dimethylbicyclo[3.1.1]heptane derivatives. J. Med. Chem. 46 2003 2446 2455 (Pubitemid 36637928)
25. J.J. Murray, A.B. Tonnel, A.R. Brash, L.J. Roberts II, P. Gosset, R. Workman, A. Capron, and J.A. Oates Release of prostaglandin D2 into human airways during acute antigen challenge N. Egnl. J. Med. 315 1986 800 804 (Pubitemid 16014343)
26. L.T. Nguyen, S. Lim, T. Oates, and K.F. Chung Increase in airway neutrophils after oral but not inhaled corticosteroid therapy in mild asthma Respir. Med. 99 2005 200 207 (Pubitemid 40104275)
27. T. Oguma, L.J. Palmer, E. Birben, L.A. Sonna, K. Asano, and C.M. Lilly Role of prostanoid DP receptor variants in susceptibility to asthma N. Engl. J. Med. 351 2004 1752 1763 (Pubitemid 39383210)
28. D.F. Rogers Airway mucus hypersecretion in asthma: an undervalued pathology? Curr. Opin. Pharmacol. 4 2004 241 250 (Pubitemid 38585308)
29. R.P. Schleimer, E.S. Schulman, D.W. MacGlashan Jr.; S.P. Peters, E.C. Hayes, G.K. Adams III, L.M. Lichtenstein, and N.F. Adkinson Jr. Effects of dexamethasone on mediator release from human lung fragments and purified human lung mast cells J. Clin. Invest. 71 1983 1830 1835 (Pubitemid 13056786)
30. M. Shichijo, A. Arimura, Y. Hirano, K. Yasui, N. Suzuki, M. Deguchi, and W.M. Abraham A prostaglandin D(2) receptor antagonist modifies experimental asthma in sheep Clin. Exp. Allergy 39 2009 1404 1414
31. T. Takizawa, N. Kawada, H. Tanaka, and H. Nagai Effect of antiallergic drugs on interleukin 5-induced eosinophil infiltration of rat airways Biol. Pharm. Bull. 25 2002 318 322 (Pubitemid 39663282)
32. P.G. Woodruff, R. Khashayar, S.C. Lazarus, S. Janson, P. Avila, H.A. Boushey, M. Segal, and J.V. Fahy Relationship between airway inflammation, hyperresponsiveness, and obstruction in asthma J. Allergy Clin. Immunol. 108 2001 753 758 (Pubitemid 33096206)