Approaches to cancer assessment in EPA's Integrated Risk Information System

Toxicology and Applied Pharmacology

Volumn 254, Issue 2, 2011, Pages 170-180

  Gehlhaus, Martin W ^a   Gift, Jeffrey S ^b   Hogan, Karen A ^a   Kopylev, Leonid ^a   Schlosser, Paul M ^b   Kadry, Abdel Razak ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Cancer; Dose response modeling; Mode of action; Physiologically based pharmacokinetic models; Risk assessment; Statistical methods

Indexed keywords

1,2,3 TRICHLOROPROPANE; 2 BUTOXYETHANOL; CARCINOGEN; CYCLOPROPANE DERIVATIVE; CYTOCHROME P450 2E1; DICHLOROMETHANE; GLUTATHIONE TRANSFERASE T1; MUTAGENIC AGENT; UNCLASSIFIED DRUG;

ANGIOSARCOMA; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; DATA BASE; DNA ADDUCT; DNA DAMAGE; DNA REPAIR; DNA SYNTHESIS; DOSE RESPONSE; ENVIRONMENTAL EXPOSURE; GENE MUTATION; GOVERNMENT; HEALTH PROGRAM; HEMOLYSIS; HUMAN; INDIVIDUALITY; INFORMATION SYSTEM; INTEGRATED RISK INFORMATION SYSTEM; IONIZING RADIATION; KIDNEY CANCER; LIVER CANCER; LIVER HEMANGIOSARCOMA; MOLECULAR MODEL; MONTE CARLO METHOD; NONHUMAN; OXIDATIVE STRESS; PHYSIOLOGICALLY BASED PHARMACOKINETIC; PRACTICE GUIDELINE; PROBABILITY; PUBLICATION; QUANTITATIVE ANALYSIS; REVIEW; RISK ASSESSMENT; THYROID CANCER; TREND STUDY;

ANIMALS; CARCINOGENS, ENVIRONMENTAL; ENVIRONMENTAL EXPOSURE; HUMANS; INFORMATION SYSTEMS; NEOPLASMS; PROPANE; RISK ASSESSMENT; UNITED STATES; UNITED STATES ENVIRONMENTAL PROTECTION AGENCY;

EID: 79960013955     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.10.019     Document Type: Review

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