Carbohydrate-remodelled acid α-glucosidase with higher affinity for the cation-independent mannose 6-phosphate receptor demonstrates improved delivery to muscles of Pompe mice

Biochemical Journal

Volumn 389, Issue 3, 2005, Pages 619-628

  Zhu, Yunxiang ^a   Li, Xuemei ^a   McVie Wylie, Alison ^a   Jiang, Canwen ^a   Thurberg, Beth L ^a   Raben, Nina ^b   Mattaliano, Robert J ^a   Cheng, Seng H ^a  

^a GENZYME CORPORATION   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acid glucosidase; Carbohydrate remodelling; Cation independent mannose 6 phosphate receptor; Enzyme replacement therapy; Lysosomal storage disorders; Pompe disease

Indexed keywords

DISEASES; DOSIMETRY; DRUG THERAPY; ENZYMES; GLUCOSE; ORGANIC ACIDS; PHOSPHATES; REDUCTION;

ACID Α-GLUCOSIDASE; CARBOHYDRATE REMODELLING; CATION-INDEPENDENT MANOSE 6-PHOSPHATE RECEPTOR; ENZYME REPLACEMENT THERAPY; LYSOSOMAL STORAGE DISORDER; POMPE DISEASE;

CARBOHYDRATES;

CARBOHYDRATE; GLUCAN 1,4 ALPHA GLUCOSIDASE; GLYCOGEN; OLIGOSACCHARIDE; RECOMBINANT GLUCAN 1,4 ALPHA GLUCOSIDASE; SOMATOMEDIN B RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DIAPHRAGM; DOSE RESPONSE; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG TISSUE LEVEL; ENZYME ACTIVITY; ENZYME REPLACEMENT; GLYCOGEN METABOLISM; GLYCOGEN STORAGE DISEASE TYPE 2; HEART; HUMAN; MOUSE; MYOBLAST; NONHUMAN; PRIORITY JOURNAL; REDUCTION; SKELETAL MUSCLE; TREATMENT OUTCOME;

AGING; ALPHA-GLUCOSIDASES; ANIMALS; GLUCAN 1,4-ALPHA-GLUCOSIDASE; GLYCOGEN; GLYCOGEN STORAGE DISEASE TYPE II; MICE; MOLECULAR STRUCTURE; MUSCLE, SKELETAL; MYOCARDIUM; OLIGOSACCHARIDES; PROTEIN BINDING; RECEPTOR, IGF TYPE 2; RECOMBINANT PROTEINS;

EID: 23644435652     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20050364     Document Type: Article

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