Phenylimino-10H-anthracen-9-ones as novel antimicrotubule agents - Synthesis, antiproliferative activity and inhibition of tubulin polymerization

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 14, 2011, Pages 4183-4191

  Prinz, Helge ^a   Schmidt, Peter ^c   Böhm, Konrad J ^b   Baasner, Silke ^c   Müller, Klaus ^a   Gerlach, Matthias ^c   Günther, Eckhard G ^c   Unger, Eberhard ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c Æterna Zentaris GmbH   (Germany)

Author keywords

9 (Phenylhydrazone) 9,10 anthracenediones; Antimitotic; Antiproliferative; Colchicine; Phenylimino 10H anthracen 9 ones; Tubulin

Indexed keywords

1,8 DICHLORO [10 (3 HYDROXY 4 METHOXYPHENYLIMINO)] 10H ANTHRACEN 9 ONE; 1,8 DICHLORO [10 (4 METHOXYPHENYLIMINO)] 10H ANTHRACEN 9 ONE; 10 (2,4 DIMETHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (2,5 DIMETHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3 HYDROXY 4 METHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3,4 DIMETHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3,4 METHYLENEDIOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3,4,5 TRIMETHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3,5 DIMETHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 (4 METHOXYPHENYLIMINO) 10H ANTHRACEN 9 ONE; 10 BROMO 1,8 DICHLORO 10H ANTRACEN 9 ONE; 10 BROMO 10H ANTHRACEN 9 ONE; 9 [(2 PHENYL)HYDRAZONE] 9,10 ANTHRACENEDIONE; 9 [(2,5 DIMETHOXYPHENYL)HYDRAZONE] 9,10 ANTHRACENEDIONE; 9 [(3,4,5 TRIMETHOXYPHENYL)HYDRAZONE] 9,10 ANTHRACENEDIONE; 9 [2 (3 METHOXYPHENYL)HYDRAZONE] 9,10 ANTHRACENEDIONE; 9 [2 (4 METHOXYPHENYL)HYDRAZONE] 9,10 ANTHRACENEDIONE; COLCHICINE; CYTOTOXIC AGENT; DOXORUBICIN; NOCODAZOLE; PACLITAXEL; PHENYLIMINO 10H ANTHRACEN 9 ONE DERIVATIVE; PODOPHYLLOTOXIN; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE SULFATE;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CELL STRAIN K 562; CONTROLLED STUDY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; MICROTUBULE ASSEMBLY; PHARMACOLOGICAL BLOCKING; PHENOTYPE;

ANTHRACENES; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; MICROTUBULES; MOLECULAR STRUCTURE; SCHIFF BASES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 79959992870     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.06.010     Document Type: Article

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