Synthesis, antiprolife ativeactivity and inhibition of tubulinpolymerization byanthracenone-based oxime derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3354-3364

  Surkau, Georg ^a   Böhm, Konrad J ^b   Müller, Klaus ^a   Prinz, Helge ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

10 Hydroxyimino 10H anthracen 9 ones; Anthracenones; Anthraquinone oximes; Antiproliferative activity; Tubulin polymerization

Indexed keywords

1,5 DICHLORO 10 (3,4,5 TRIMETHOXYBENZOYLIMINO) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (3,4,5 TRIMETHOXYBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (4 METHOXYBENZOYLOXYIMINO) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (4 METHOXYBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (4 METHOXYPHENYLSULPHONYLOXYIMINO) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 HYDROXYIMINO 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (4 METHOXYBENZOYLIMINO) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (4 METHOXYBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 HYDROXYIMINO 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10H ANTHRACENE 9 ONE; 1,8 DIMETHOXY 10 (3 HYDROXY 4 METHOXYBENZYLIMINO) 10H ANTHRACEN 9 ONE; 1,8 DIMETHOXY 10 (4 METHOXYBENZYLIMINO) 10H ANTHRACEN 9 ONE; 1,8 DIMETHOXY ANTHRACEN 9,10 DIONE; 10 (3 HYDROXY 4 METHOXYBENZOYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (3 HYDROXY 4 METHOXYBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (3,4,5 TRIMETHOXYBENZOYLIMINO) 10H ANTHRACEN 9 ONE; 10 (3,4,5 TRIMETHOXYBENZYLIMINO) 10H ANTHRACEN 9 ONE; 10 (4 CHLOROBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (4 HYDROXY 3 METHOXYBENZOYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (4 METHOXYBENZOYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (4 METHOXYBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (4 METHOXYPHENYLSULPHONYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 (4 NITROBENZYLOXYIMINO) 10H ANTHRACEN 9 ONE; 10 BENZYLOXYIMINO 10H ANTHRACEN 9 ONE; 10 HYDROXYIMINO 10H ANTHRACEN 9 ONE; ANTHRACENONE DERIVATIVE; ANTINEOPLASTIC AGENT; OXIME DERIVATIVE; TUBULIN; UNCLASSIFIED DRUG; ANTHRACENE DERIVATIVE; OXIME;

ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG INHIBITION; DRUG MECHANISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; LEUKEMIA CELL; POLYMERIZATION; CELL PROLIFERATION; CELL STRAIN K 562; CHEMISTRY; DRUG EFFECT; IC 50; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SYNTHESIS;

ANTHRACENES; ANTINEOPLASTIC AGENTS; CELL PROLIFERATION; HUMANS; INHIBITORY CONCENTRATION 50; K562 CELLS; OXIMES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; TUBULIN;

EID: 77954314150     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.019     Document Type: Article

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