Synthesis, antiprolife ativeactivity and inhibition of tubulinpolymerization by 1,5-and 1,8-disubstituted 10H-anthracen-9-onesbearinga 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety

European Journal of Medicinal Chemistry

Volumn 45, Issue 8, 2010, Pages 3420-3438

  Nickel, Holger C ^a   Schmidt, Peter ^c   Böhm, Konrad J ^b   Baasner, Silke ^c   Müller, Klaus ^a   Gerlach, Matthias ^c   Unger, Eberhard ^b   Günther, Eckhard G ^c   Prinz, Helge ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b FRITZ LIPMANN INSTITUTE   (Germany)

^c Æterna Zentaris GmbH   (Germany)

Author keywords

10 (2 Oxo 2 phenylethylidene) 10Hanthracen 9 ones; Antimitotic; Antiproliferative; Benzylidene 10H anthracen 9 ones; Colchicine; Tubulin

Indexed keywords

1,5 DICHLORO 10 (3 HYDROXY 4 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (3,4,5 TRIMETHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10 (4 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,5 DICHLORO 10(3 METHOXYBENZYL) 10H ANTHRACE 9 ONE; 1,5 DICHLORO 10(4 METHOXYBENZYL) 10H ANTHRACE 9 ONE; 1,8 DICHLORO 10 (2 HYDROXY 3 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (2 HYDROXY 4 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (2,4 DIMETHOXY 3 HYDROXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (2,4 DIMETHOXY 4 HYDROXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (3 HYDROXY 4 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (3,4,5 TRIMETHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (3,5 DIMETHOXY 4 HYDROXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (4 HYDROXY 3 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO 10 (4 METHOXYBENZYLIDENE) 10H ANTHRACEN 9 ONE; 1,8 DICHLORO [10 (3 BENZYLOXY 4 METHOXYPHENYLMETHYL)] 10H ANTHRACE 9 ONE; 1,8 DICHLORO [10 (3 HYDROXY 4 METHOXYPHENYLMETHYL)] 10H ANTHRACE 9 ONE; 1,8 DICHLORO [10 (4 METHOXYPHENYLMETHYL)] 10H ANTHRACE 9 ONE; 1,8 DIHYDROXY 10 (3 HYDROXY 4 METHOXYBENZYLIDENE) 10H ANTHRACE 9 ONE; 10 (3 BENZYLOXY 4 METHOXYBENZYLIDENE) 1,5 DICHLORO 10H ANTHRACEN 9 ONE; 10 BENZYL 1,5 DICHLORO 10H ANTHRACE 9 ONE; 10 BENZYLIDENE 1,5 DICHLORO 10H ANTHRACEN 9 ONE; ANTHRACENE DERIVATIVE; COLCHICINE; DOXORUBICIN; NOCODAZOLE; PACLITAXEL; PODOPHYLLOTOXIN; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; ANTINEOPLASTIC AGENT; BENZYLIDENE DERIVATIVE;

ARTICLE; BIOLOGICAL ACTIVITY; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; POLYMERIZATION; SUBSTITUTION REACTION; CELL CYCLE; CHEMISTRY; DRUG EFFECT; METABOLISM; PROTEIN MULTIMERIZATION; PROTEIN QUATERNARY STRUCTURE; SYNTHESIS; TUMOR CELL LINE;

ANTHRACENES; ANTINEOPLASTIC AGENTS; BENZYLIDENE COMPOUNDS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; TUBULIN;

EID: 77954315595     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.04.032     Document Type: Article

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