Expression of vascular endothelial growth factor and pigment epithelial-derived factor in a rat model of retinopathy of prematurity

Molecular Vision

Volumn 17, Issue , 2011, Pages 1577-1587

  Hartmann, John S ^a   Thompson, Hilary ^c   Wang, Haibo ^a,b   Kanekar, Shami ^b   Huang, Wei ^a   Budd, Steven J ^a   Elizabeth Hartnett, M ^a,b  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PIGMENT EPITHELIUM DERIVED FACTOR; VASCULOTROPIN;

AGE; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CLINICAL FEATURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; NEWBORN; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RETINA NEOVASCULARIZATION; RETROLENTAL FIBROPLASIA;

ANIMALS; ANIMALS, NEWBORN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE PROTEINS; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; INFANT, NEWBORN; NEOVASCULARIZATION, PATHOLOGIC; NERVE GROWTH FACTORS; OXYGEN; POLYMERASE CHAIN REACTION; RATS; RETINA; RETINAL VESSELS; RETINOPATHY OF PREMATURITY; RNA, MESSENGER; SERPINS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79959971025     PISSN: None     EISSN: 10900535     Source Type: Journal    
DOI: None     Document Type: Article

References (66)

1. Terry TL. Extreme prematurity and fibroblastic overgrowth of persistent vascular sheath behind each crystalline lens:(1) Preliminary report. Am J Ophthalmol 1942; 25:203-204.
2. Ashton N, Ward B, Serpell G. Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia. Br J Ophthalmol 1954; 38:397-432. [PMID: 13172417]
3. Patz A, Eastham A, Higginbotham DH, Kleh T. Oxygen studies in retrolental fibroplasia. Am J Ophthalmol 1953; 36:1511-1522. [PMID: 13104558]
4. Allen MC, Donohue PK, Dusman AE. The limit of viability-neonatal outcome of infants born at 22 to 25 weeks' gestation. N Engl J Med 1993; 329:1597-1601. [PMID: 8179651]
5. Phelps DL. Retinopathy of prematurity: an estimate of vision loss in the United States-1979. Pediatrics 1981; 67:924-925. [PMID: 6894488]
6. Gallo JE, Jacobsen L, Broberger U. Perinatal factors associated with retinopathy of prematurity. Acta Paediatr 1993; 82:829-834. [PMID: 8241640]
7. Hellström A, Hård AL, Engström E, Niklasson A, Andersson E, Smith L, Löfqvist C. Early Weight Gain Predicts Retinopathy in Preterm Infants: New, Simple, Efficient Approach to Screening. Pediatrics 2009; 123:e638-e645. [PMID: 19289449]
8. Cunningham S, Fleck BW, Elton RA, Mclntosh N. Transcutaneous oxygen levels in retinopathy of prematurity. Lancet 1995; 346:1464-1465. [PMID: 7490994]
9. Chow LC, Wright KW, Sola A. Can changes in clinical practice decrease the incidence of severe retinopathy of prematurity in very low birth weight infants? Pediatrics 2003; 111:339-345. [PMID: 12563061]
10. SUPPORT Study Group of the Eunice Kennedy Shriver NICHD Neonatal Research Network. Target Ranges of Oxygen Saturation in Extremely Preterm Infants. N Engl J Med 2010; 362:1959-1969. [PMID: 20472937]
11. Michaelson IC. The mode of development of the vascular system of the retina. With some observations on its significance for certain retinal diseases. Trans Ophthalmol Soc U K 1948; 68:137-180.
12. Ferrara N. Role of vascular endothelial growth factor in the regulation of angiogenesis. Kidney Int 1999; 56:794-814. [PMID: 10469350]
13. Pierce EA, Avery RL, Foley ED, Aiello LP, Smith LEH. Vascular endothelial growth factor/vascular permeability factor expression in a mouse model of retinal neovascularization. Proc Natl Acad Sci USA 1995; 92:905-909. [PMID: 7846076]
14. Penn JS, Tolman BL, Lowery LA. Variable oxygen exposure causes preretinal neovascularisation in the newborn rat. Invest Ophthalmol Vis Sci 1993; 34:576-585. [PMID: 8449677]
15. Zeng G, Taylor SM, McColm JR, Kappas NC, Kearney JB, Williams LH, Hartnett ME, Bautch VL. Orientation of endothelial cell division is regulated by VEGF signaling during blood vessel formation. Blood 2007; 109:1345-1352. [PMID: 17068148]
16. Sone H, Kawakami Y, Segawa T, Okuda Y, Sekine Y, Honmura S, Segawa T, Suzuki H, Yamashita K, Yamada N. Effects of intraocular or systemic administration of neutralizing antibody against vascular endothelial growth factor on the murine experimental model of retinopathy. Life Sci 1999; 65:2573-2580. [PMID: 10619365]
17. Krzystolik MG, Afshari MA, Adamis AP, Gaudreault J, Gragoudas ES, Michaud NA, Li W, Connolly E, O'Neill CA, Miller JW. Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment. Arch Ophthalmol 2002; 120:338-346. [PMID: 11879138]
18. Budd S, Byfield G, Martiniuk D, Geisen P, Hartnett ME. Reduction in endothelial tip cell filopodia corresponds to reduced intravitreous but not intraretinal vascularization in a model of ROP. Exp Eye Res 2009; 89:718-727. [PMID: 19576214]
19. Geisen P, Peterson L, Martiniuk D, Uppal A, Saito Y, Hartnett M. Neutralizing antibody to VEGF reduces intravitreous neovascularization and does not interfere with vascularization of avascular retina in an ROP model. Mol Vis 2008; 14:345-357. [PMID: 18334951]
20. Robinson GS, Pierce EA, Rook SL, Foley E, Webb R, Smith LEH. Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy. Proc Natl Acad Sci USA 1996; 93:4851-4856. [PMID: 8643492]
21. Young TL, Anthony DC, Pierce E, Foley E, Smith LEH. Histopathology and vascular endothelial growth factor in untreated and diode laser-treated retinopathy of prematurity. J AAPOS 1997; 1:105-110. [PMID: 10875087]
22. Sonmez K, Drenser KA, Capone A Jr, Trese MT. Vitreous Levels of Stromal Cell-Derived Factor 1 and Vascular Endothelial Growth Factor in Patients with Retinopathy of Prematurity. Ophthalmology 2008; 115:1065-1070. [PMID: 18031819]
23. Mintz-Hittner HA, Kuffel RR. Jr. Intravitreal injection of bevacizumab (avastin) for treatment of stage 3 retinopathy of prematurity in zone I or posterior zone II. Retina 2008; 28:831-838. [PMID: 18536599]
24. Jang SY, Choi KS, Lee SJ. Delayed-onset retinal detachment after an intravitreal injection of ranibizumab for zone 1 plus retinopathy of prematurity. Journal of American Association for Pediatric Ophthalmology and Strabismus 2010; 14:457-459. [PMID: 21035077]
25. Tombran-Tink J, Barnstable CJ. PEDF: A multifaceted neurotrophic factor. Nat Rev Neurosci 2003; 4:628-636. [PMID: 12894238]
26. Stellmach V, Crawford SE, Zhou W, Bouck N. Prevention of ischemia-induced retinopathy by the natural ocular antiangiogenic agent pigment epithelium-derived factor. Proc Natl Acad Sci USA 2001; 98:2593-2597. [PMID: 11226284]
27. Duh EJ, Yang HS, Suzuma I, Miyagi M, Youngman E, Mori K, Katai M, Yan L, Suzuma K, West K, Davarya S, Tong P, Gehlbach P, Pearlman J, Crabb JW, Aiello LP, Campochiaro PA, Zack DJ. Pigment epithelium-derived factor suppresses ischemia-induced retinal neovascularization and VEGF induced migration and growth. Invest Ophthalmol Vis Sci 2002; 43:821-829. [PMID: 11867604]
28. Apte RS, Barreiro RA, Duh E, Volpert O, Ferguson TA. Stimulation of Neovascularization by the Anti-angiogenic Factor PEDF. Invest Ophthalmol Vis Sci 2004; 45:4491-4497. [PMID: 15557459]
29. Bhutto IA, McLeod DS, Hasegawa T, Kim SY, Merges C, Tong P, Lutty GA. Pigment epithelium-derived factor (PEDF) and vascular endothelial growth factor (VEGF) in aged human choroid and eyes with age-related macular degeneration. Exp Eye Res 2006; 82:99-110. [PMID: 16019000]
30. Ogata N, Nishikawa M, Nishimura T, Mitsuma Y, Matsumura M. Unbalanced vitreous levels of pigment epithelium-derived factor and vascular endothelial growth factor in diabetic retinopathy. Am J Ophthalmol 2002; 134:348-353. [PMID: 12208245]
31. Campochiaro PA, Nguyen QD, Shah SM, Klein ML, Holz E, Frank RN, Saperstein DA, Gupta A, Stout JT, Macko J, DiBartolomeo R, Wei LL. Adenoviral vector-delivered pigment epithelium-derived factor for neovascular agerelated macular degeneration: results of a phase I clinical trial. Hum Gene Ther 2006; 17:167-176. [PMID: 16454650]
32. Zhang SX, Wang JJ, Gao G, Parke K, Ma J. Pigment epithelium derived factor downregulates vascular endothelial growth factor (VEGF) expression and inhibits VEGF-VEGF receptor 2 binding in diabetic retinopathy. J Mol Endocrinol 2006; 37:1-12. [PMID: 16901919]
33. Ohno-Matsui K, Morita I, Tombran-Tink J, Mrazek D, Onodera M, Uetama T, Hayano M, Murota SI, Mochizuki M. Novel mechanism for age-related macular degeneration: An equilibrium shift between the angiogenesis factors VEGF and PEDF. J Cell Physiol 2001; 189:323-333. [PMID: 11748590]
34. Gao G, Li Y, Fant J, Crosson CE, Becerra SP, Ma J. Difference in ischemic regulation of vascular endothelial growth factor and pigment epithelium-derived factor in Brown Norway and Sprague Dawley rats contributing to different susceptibilities to retinal neovascularization. Diabetes 2002; 51:1218-1225. [PMID: 11916948]
35. Gao G, Li Y, Zhang D, Gee S, Crosson C, Ma J. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett 2001; 489:270-276. [PMID: 11165263]
36. Zhang SX, Wang JJ, Dashti A, Wilson K, Zou MH, Szweda L, Ma JX, Lyons TJ. Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein. J Mol Endocrinol 2008; 41:135-143. [PMID: 18586837]
37. Gao G, Li Y, Zhang D, Gee S, Crosson C, Ma J. Unbalanced expression of VEGF and PEDF in ischemia-induced retinal neovascularization. FEBS Lett 2001; 489:270-276. [PMID: 11165263]
38. Smith LE, Wesolowski E, McLellan A, Kostyk SK, D'Amato R, Sullivan R, D'Amore PA. Oxygen induced retinopathy in the mouse. Invest Ophthalmol Vis Sci 1994; 35:101-111. [PMID: 7507904]
39. Hartnett ME. Studies on the Pathogenesis of Avascular Retina and Neovascularization into the Vitreous in Peripheral Severe Retinopathy of Prematurity (An American Ophthalmological Society Thesis). Trans Am Ophthalmol Soc 2010; 108:96-119. [PMID: 21212851]
40. Penn JS, Henry MM, Tolman BL. Exposure to alternating hypoxia and hyperoxia causes severe proliferative retinopathy in the newborn rat. Pediatr Res 1994; 36:724-731. [PMID: 7898981]
41. Hartnett ME, Martiniuk DJ, Saito Y, Geisen P, Peterson LJ, McColm JR. Triamcinolone Reduces Neovascularization, Capillary Density and IGF-1 Receptor Phosphorylation in a Model of Oxygen-Induced Retinopathy. Invest Ophthalmol Vis Sci 2006; 47:4975-4982. [PMID: 17065516]
42. Liu K, Akula JD, Falk C, Hansen RM, Fulton AB. The Retinal Vasculature and Function of the Neural Retina in a Rat Model of Retinopathy of Prematurity. Invest Ophthalmol Vis Sci 2006; 47:2639-2647. [PMID: 16723481]
43. Penn JS, Tolman BL, Henry MM. Oxygen-induced retinopathy in the rat: Relationship of retinal nonperfusion to subsequent neovascularization. Invest Ophthalmol Vis Sci 1994; 35:3429-3435. [PMID: 8056518]
44. Fulton AB, Hansen RM, Moskowitz A, Akula JD. The neurovascular retina in retinopathy of prematurity. Prog Retin Eye Res 2009; 28:452-482. [PMID: 19563909]
45. Byfield G, Budd S, Hartnett ME. The role of supplemental oxygen and JAK/STAT signaling in intravitreous neovascularization in a ROP rat model. Invest Ophthalmol Vis Sci 2009; 50:3360-3365. [PMID: 19264880]
46. Saito Y, Uppal A, Byfield G, Budd S, Hartnett ME. Activated NAD(P)H Oxidase from Supplemental Oxygen Induces Neovascularization Independent of VEGF in Retinopathy of Prematurity Model. Invest Ophthalmol Vis Sci 2008; 49:1591-1598. [PMID: 18385079]
47. Werdich XQ, Penn JS. Specific Involvement of Src Family Kinase Activation in the Pathogenesis of Retinal Neovascularization. Invest Ophthalmol Vis Sci 2006; 47:5047-5056. [PMID: 17065526]
48. Barnett JM, McCollum GW, Penn JS. Role of Cytosolic Phospholipase A2 in Retinal Neovascularization. Invest Ophthalmol Vis Sci 2010; 51:1136-1142. [PMID: 19661235]
49. Yanni SE, Barnett JM, Clark ML, Penn JS. The Role of PGE2 Receptor EP4 in Pathologic Ocular Angiogenesis. Invest Ophthalmol Vis Sci 2009; 50:5479-5486. [PMID: 19494202]
50. Chan-Ling T. Glial, vascular and neuronal cytogenesis in whole-mounted cat retina. Microsc Res Tech 1997; 36:1-16. [PMID: 9031257]
51. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the folin phenol reagent. J Biol Chem 1951; 193:265-275. [PMID: 14907713]
52. McColm JR, Geisen P, Hartnett ME. VEGF isoforms and their expression after a single episode of hypoxia or repeated fluctuations between hyperoxia and hypoxia: Relevance to clinical ROP. Mol Vis 2004; 10:512-520. [PMID: 15303088]
53. Penn JS, McCollum GW, Barnett JM, Werdich XQ, Koepke KA, Rajaratnam VS. Angiostatic Effect of Penetrating Ocular Injury: Role of Pigment Epithelium-Derived Factor. Invest Ophthalmol Vis Sci 2006; 47:405-414. [PMID: 16384991]
54. Vandesompele J, De Preter K, Pattyn F, Poppe B, Van Roy N, De Paepe A, Speleman F. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002; 3:RESEARCH0034. [PMID: 12184808]
55. Edwards D, Berry JJ. The efficiency of simulation-based multiple comparisons. Biometrics 1987; 43:913-928. [PMID: 3427176]
56. Budd SJ, Thompson H, Hartnett ME. Association of Retinal Vascular Endothelial Growth Factor With Avascular Retina in a Rat Model of Retinopathy of Prematurity. Arch Ophthalmol 2010; 128:1014-1021. [PMID: 20697002]
57. Chan-Ling T, Gock B, Stone J. The effect of oxygen on vasoformative cell division: Evidence that 'physiological hypoxia' is the stimulus for normal retinal vasculogenesis. Invest Ophthalmol Vis Sci 1995; 36:1201-1214. [PMID: 7775098]
58. Stone J, Itin A, Alon T, Pe'er J, Gnessin H, Chan-Ling T, Keshet E. Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia. J Neurosci 1995; 15:4738-4747. [PMID: 7623107]
59. Dawson DW, Volpert OV, Gillis P, Crawford SE, Xu H, Benedict W, Bouck NP. Pigment epithelium-derived factor: a potent inhibitor of angiogenesis. Science 1999; 285:245-248. [PMID: 10398599]
60. Ferrara N, Gerber HP, Lecouter J. The biology of VEGF and its receptors. Nat Med 2003; 9:669-676. [PMID: 12778165]
61. Werdich XQ, McCollum GW, Rajaratnam VS, Penn JS. Variable oxygen and retinal VEGF levels: correlation with incidence and severity of pathology in a rat model of oxygeninduced retinopathy. Exp Eye Res 2004; 79:623-630. [PMID: 15500821]
62. Lutty GA, Chan-Ling T, Phelps DL, Adamis AP, Berns KI, Chan CK, Cole CH, D'Amore PA, Das A, Deng WT, Dobson V, Flynn JT, Friedlander M, Fulton A, Good WV, Grant MB, Hansen R, Hauswirth WW, Hardy RJ, Hinton DR, Hughes S, McLeod DS, Palmer EA, Patz A, Penn JS, Raisler BJ, Repka MX, Saint-Geniez M, Shaw LC, Shima DT, Smith BT, Smith LE, Tahija SG, Tasman W, Trese MT. Proceedings of the Third International Symposium on Retinopathy of Prematurity: an update on ROP from the lab to the nursery (November 2003, Anaheim, California). Mol Vis 2006; 12:532-580. [PMID: 16735995]
63. Volpert OV, Zaichuk T, Zhou W, Reiher F, Ferguson TA, Stuart PM, Amin M, Bouck NP. Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat Med 2002; 8:349-357. [PMID: 11927940]
64. Zhang SX, Wang JJ, Dashti A, Wilson K, Zou MH, Szweda L, Ma JX, Lyons TJ. Pigment epithelium-derived factor mitigates inflammation and oxidative stress in retinal pericytes exposed to oxidized low-density lipoprotein. J Mol Endocrinol 2008; 41:135-143. [PMID: 18586837]
65. Wong WT, Rex TS, Auricchio A, Maguire AM, Chung D, Tang W, Bennett J. Effect of over-expression of pigment epithelium derived factor (PEDF) on developing retinal vasculature in the mouse. Mol Vis 2004; 10:837-844. [PMID: 15547489]
66. Huang Q, Wang S, Sorenson CM, Sheibani N. PEDF-deficient mice exhibit an enhanced rate of retinal vascular expansion and are more sensitive to hyperoxia-mediated vessel obliteration. Exp Eye Res 2008; 87:226-241. [PMID: 18602915]