Placental Trophoblast Inclusions in Autism Spectrum Disorder

Biological Psychiatry

Volumn 61, Issue 4, 2007, Pages 487-491

  Anderson, George M ^a,b   Jacobs Stannard, Andrea ^b   Chawarska, Katarzyna ^a   Volkmar, Fred R ^a   Kliman, Harvey J ^b  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Autism; early screening; marker; placenta; trophoblast; trophoblast inclusion

Indexed keywords

ARTICLE; AUTISM; BIRTH; CELL INCLUSION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE SEVERITY; FISHER EXACT TEST; HUMAN; HUMAN TISSUE; MICROSCOPY; PLACENTA; PRIORITY JOURNAL; RISK FACTOR; STATISTICAL ANALYSIS; TISSUE SECTION; TROPHOBLAST;

ADOLESCENT; ANALYSIS OF VARIANCE; AUTISTIC DISORDER; CELL COUNT; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; FEMALE; HUMANS; INCLUSION BODIES; MALE; MODELS, BIOLOGICAL; PLACENTA; RETROSPECTIVE STUDIES; STAINING AND LABELING; TROPHOBLASTS;

EID: 33846636775     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2006.03.068     Document Type: Article

References (55)

1. Adrien J.L., Roux S., Couturier G., Malvy J., Guerin P., Debuly S., et al. Towards a new functional assessment of autistic dysfunction in children with developmental disorders: the Behaviour Function Inventory. Autism 5 (2001) 249-264
2. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th ed. (1994), American Psychiatric Association, Washington, DC
3. Anderson G.M. Genetics of childhood disorders: XLV. Autism, part 4: serotonin in autism. J Am Acad Child Adolesc Psychiatry 41 (2002) 1513-1516
4. Bailey A., Le Couteur A., Gottesman I., Bolton P., Simonoff E., Yuzda E., and Rutter M. Autism as a strongly genetic disorder: evidence from a British twin study. Psychol Med 25 (1995) 63-77
5. Bolte S., and Poustka F. [Factor structure of the Autism Diagnostic Interview-Revised (ADI-R): a study of dimensional versus categorical classification of autistic disorders]. Z Kinder Jugendpsychiatr Psychother 29 (2001) 221-229
6. Bolton P., Macdonald H., Pickles A., Rios P., Goode S., Crowson M., et al. A case-control family history study of autism. J Child Psychol Psychiatry 35 (1994) 877-900
7. Bolton P.F., Murphy M., Macdonald H., Whitlock B., Pickles A., and Rutter M. Obstetric complications in autism: consequences or causes of the condition?. J Am Acad Child Adolesc Psychiatry 36 (1997) 272-281
8. Boyd J.D., and Hamilton W.J. The Human Placenta (1970), W. Heffer & Sons Ltd, Cambridge
9. Burd L., Severud R., Kerbeshian J., and Klug M.G. Prenatal and perinatal risk factors for autism. J Perinat Med 27 (1999) 441-450
10. Buznikov G.A., Lambert H.W., and Lauder J.M. Serotonin and serotonin-like substances as regulators of early embryogenesis and morphogenesis. Cell Tissue Res 305 (2001) 177-186
11. Carrasco G., Cruz M.A., Dominguez A., Gallardo V., Miguel P., and Gonzalez C. The expression and activity of monoamine oxidase A, but not of the serotonin transporter, is decreased in human placenta from pre-eclamptic pregnancies. Life Sciences 67 (2000) 2961-2969
12. Cook Jr. E.H. Genetics of autism. Child Adolesc Psychiatr Clin N Am 10 (2001) 333-350
13. Fecteau K.A., and Eiler H. Placenta detachment: unexpected high concentrations of 5-hydroxytryptamine (serotonin) in fetal blood and its mitogenic effect on placental cells in bovine. Placenta 22 (2001) 103-110
14. Folstein S., and Rutter M. Genetic influences and infantile autism. Nature 265 (1977) 726-728
15. Folstein S.E., and Rosen-Sheidley B. Genetics of autism: complex aetiology for a heterogeneous disorder. Nat Rev Genet 2 (2001) 943-955
16. Genest D.R., Roberts D., Boyd T., and Bieber F.R. Fetoplacental histology as a predictor of karyotype: a controlled study of spontaneous first trimester abortions. Hum Pathol 26 (1995) 201-209
17. Glasson E.J., Bower C., Petterson B., de Klerk N., Chaney G., and Hallmayer J.F. Perinatal factors and the development of autism: a population study. Arch Gen Psychiatry 61 (2004) 618-627
18. Gottesman, and Gould T.D. The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160 (2003) 636-645 II
19. Gottesman, and Hanson D.R. Human development: biological and genetic processes. II. Ann Rev Psychology 56 (2005) 263-286
20. Honore L., Dill F.J., and Poland B.J. Placental morphology in spontaneous human abortuses with normal and abnormal karyotypes. Teratology 14 (1976) 151-166
21. Huang W.Q., Zhang C.L., Di X.Y., and Zhang R.Q. Studies on the localization of 5-hydroxytryptamine and its receptors in human placenta. Placenta 19 (1998) 655-661
22. Hultman C.M., Sparen P., and Cnattingius S. Perinatal risk factors for infantile autism. Epidemiology 13 (2002) 417-423
23. Huppertz B., Tews D.S., and Kaufmann P. Apoptosis and syncytial fusion in human placental trophoblast and skeletal muscle. Int Rev Cytol 205 (2001) 215-253
24. Janusonis S., Gluncic V., and Rakic P. Early serotonergic projections to Cajal-Retzius cells: relevance for cortical development. J Neurosci 24 (2004) 1652-1659
25. Jones M.B., and Szatmari P. A risk-factor model of epistatic interaction, focusing on autism. Am J Med Genet 114 (2002) 558-565
26. Juul-Dam N., Townsend J., and Courchesne E. Prenatal, perinatal, and neonatal factors in autism, pervasive developmental disorder-not otherwise specified, and the general population. Pediatrics 107 (2001) E63
27. Kliman H.J. Trophoblast to Human Placenta, Encyclopedia of Reproduction (1999), Academic Press pp 834-846
28. Kliman H.J., Nestler J.E., Sermasi E., Sanger J.M., and Strauss III J.F. Purification, characterization, and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinology 118 (1986) 1567-1582
29. Kliman H.J., and Segel L. The placenta may predict the baby. J Theor Biol 225 (2003) 143-145
30. Larsson H.J., Eaton W.W., Madsen K.M., Vestergaard M., Olesen A.V., Agerbo E., et al. Risk factors for autism: perinatal factors, parental psychiatric history, and socioeconomic status. Am J Epidemiol 161 (2005) 916-925 discussion 926-8
31. Lauritsen M., and Ewald H. The genetics of autism. Acta Psychiatr Scand 103 (2001) 411-427
32. Leboyer M., Bellivier F., Nosten-Bertrand M., Jouvent R., Pauls D., and Mallet J. Psychiatric genetics: search for phenotypes. Trends in Neurosciences 21 (1998) 102-105
33. Lord C., Risi S., Lambrecht L., Cook Jr. E.H., Leventhal B.L., DiLavore P.C., et al. The autism diagnostic observation schedule-generic: a standard measure of social and communication deficits associated with the spectrum of autism. J Autism Dev Disord 30 (2000) 205-223
34. Lord C., Rutter M., and Le Couteur A. Autism Diagnostic Interview-Revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. J Autism Dev Disord 24 (1994) 659-685
35. Maestrini E., Paul A., Monaco A.P., and Bailey A. Identifying autism susceptibility genes. Neuron 28 (2000) 19-24
36. Matsuishi T., Yamashita Y., Ohtani Y., Ornitz E., Kuriya N., Murakami Y., et al. Brief report: incidence of and risk factors for autistic disorder in neonatal intensive care unit survivors. J Autism Dev Disord 29 (1999) 161-166
37. McBride P.A., Anderson G.M., and Shapiro T. Autism research. Bringing together approaches to pull apart the disorder.[comment]. Arch Gen Psychiatry 53 (1996) 980-983
38. Mullen E.M. Mullen Scales of Early Learning Manual (1995), American Guidance Service
39. Nguyen T.T., Tseng Y.T., McGonnigal B., Stabila J.P., Worrell L.A., Saha S., Padbury J.F., et al. Placental biogenic amine transporters: in vivo function, regulation and pathobiological significance. Placenta 20 (1999) 3-11
40. Novak R., Agamanolis D., Dasu S., Ornitz E., Kuriya N., Murakami Y., et al. Histologic analysis of placental tissue in first trimester abortions. Pediatr Pathol 8 (1988) 477-482
41. Padbury J.F., Tseng Y.T., McGonnigal B., Penado K., Stephan M., and Rudnick G. Placental biogenic amine transporters: cloning and expression. Brain Res Mol Brain Res 45 (1997) 163-168
42. Rejniak K.A., Kliman H.J., and Fauci L.J. A computational model of the mechanics of growth of the villous trophoblast bilayer. Bull Math Biol 66 (2004) 199-232
43. Risch N., Spiker D., Lotspeich L., Nouri N., Hinds D., Hallmayer J., et al. A genomic screen of autism: evidence for a multilocus etiology. Am J Hum Genet 65 (1999) 493-507
44. Silvestre E., Cusi V., Borras M., and Antich J. Cytogenetic and morphologic findings in chorionic villi from spontaneous abortions. Birth Defects Orig Artic Ser 30 (1996) 353-357
45. Skuse D.H. Endophenotypes and child psychiatry. Br J Psychiatry 178 (2001) 395-396
46. Szatmari P. Heterogeneity and the genetics of autism. J Psychiatry Neurosci 24 (1999) 159-165
47. Szatmari P., Merette C., Bryson S.E., Thivierge J., Roy M.A., Cayer M., Maziade M., et al. Quantifying dimensions in autism: a factor-analytic study. J Am Acad Child Adolesc Psychiatry 41 (2002) 467-474
48. Szulman A.E., Philippe E., Boue J.G., and Boue A. Human triploidy: association with partial hydatidiform moles and nonmolar conceptuses. Hum Pathol 12 (1981) 1016-1021
49. Tsai L.Y. The relationship of handedness to the cognitive, language, and visuo-spatial skills of autistic patients. Br J Psychiatry 142 (1983) 156-162
50. van Lijnschoten G., Arends J.W., and Geraedts J.P. Comparison of histological features in early spontaneous and induced trisomic abortions. Placenta 15 (1994) 765-773
51. Veenstra-Vanderweele J., Cook Jr. E., and Lombroso P.J. Genetics of childhood disorders: XLVI. Autism, part 5: genetics of autism. J Am Acad Child Adolesc Psychiatry 42 (2003) 116-118
52. Volkmar F.R., and Klin A. Issues in the Classification of Autism and Related Conditions. 3 ed Vol 2 (2005), Wiley, Hoboken NJ
53. Whitaker-Azmitia P.M. Serotonin and brain development: role in human developmental diseases. Brain Res Bull 56 (2001) 479-485
54. Wilkerson D.S., Volpe A.G., Dean R.S., and Titus J.B. Perinatal complications as predictors of infantile autism. Int J Neurosci 112 (2002) 1085-1098
55. Zwaigenbaum L., Szatmari P., Jones M.B., Bryson M.E., MacLean J.E., Mahoney W.J., et al. Pregnancy and birth complications in autism and liability to the broader autism phenotype. J Am Acad Child Adolesc Psychiatry 41 (2002) 572-579