Radiosensitization by celastrol is mediated by modification of antioxidant thiol molecules

Chemico-Biological Interactions

Volumn 193, Issue 1, 2011, Pages 34-42

  Seo, Haeng Ran ^a   Seo, Woo Duck ^b   Pyun, Bo Jeong ^c   Lee, Byong Won ^b   Jin, Yeung Bae ^c   Park, Ki Hun ^d   Seo, Eun Kyoung ^c   Lee, Yoon Jin ^a   Lee, Yun Sil ^c  

^a Korea Institute of Radiation and Medical Science   (South Korea)

^b National Institute of Animal Science   (South Korea)

^c Ewha Womans University   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Antioxidant; Celastrol; Radiosensitization; Reactive oxygen species

Indexed keywords

22 BETA HYDROXY TINGENONE; 3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CELASTROL; GLUTATHIONE; HERBACEOUS AGENT; IGUESTERIN; MACROGOL 400; PRISTIMERIN; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; THIOREDOXIN REDUCTASE; TINGENONE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CANCER RADIOTHERAPY; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG FORMULATION; DRUG ISOLATION; DRUG PURIFICATION; DRUG STRUCTURE; IN VITRO STUDY; IN VIVO STUDY; IONIZING RADIATION; LUNG CANCER; MOUSE; NONHUMAN; RADIOSENSITIZATION; TUMOR XENOGRAFT;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; CELL LINE, TUMOR; GLUTATHIONE; HUMANS; LUNG NEOPLASMS; MICE; MICE, NUDE; RADIATION, IONIZING; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; THIOREDOXIN-DISULFIDE REDUCTASE; TRANSPLANTATION, HETEROLOGOUS; TRITERPENES;

MUS; MUS MUSCULUS;

EID: 79959933122     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2011.04.009     Document Type: Article

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