Synthesis and enantiopreferential DNA-binding profile of late 3d transition metal R- and S-enantiomeric complexes derived from N,N-bis-(1-benzyl-2- ethoxyethane): Validation of R-enantiomer of copper(II) complex as a human topoisomerase II inhibitor

Chirality

Volumn 23, Issue 7, 2011, Pages 557-567

  Arjmand, Farukh ^a   Sharma, Girish Chandra ^a   Muddassir, Mohd ^a   Tabassum, Sartaj ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

chiral discrimination; circular dichroism cleavage efficiency; in vitro DNA binding studies; topoisomerase II inhibitor

Indexed keywords

2 AMINO 2 PHENYLETHANOL; COPPER; COPPER COMPLEX; DNA TOPOISOMERASE (ATP HYDROLYSING); ETHER DERIVATIVE; GYRASE INHIBITOR; N,N BIS(1 1 BENZYL 2 ETHOXYETHANE]COPPER CHLORIDE; N,N BIS(1 1 BENZYL 2 ETHOXYETHANE]ZINC CHLORIDE; N,N BIS(1 BENZYL 2 ETHOXYETHANE); N,N BIS(1 BENZYL 2 ETHOXYETHANE]NICKEL CHLORIDE; NICKEL; NUCLEASE; PHENETHYL ALCOHOL; SINGLET OXYGEN; SUPEROXIDE; TRANSITION ELEMENT; UNCLASSIFIED DRUG; ZINC;

ARTICLE; CIRCULAR DICHROISM; COMPLEX FORMATION; CONFORMATION; DNA BINDING; DNA CLEAVAGE; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ELECTRONIC ABSORPTION SPECTROSCOPY; ENANTIOMER; ENZYME ACTIVITY; FLUORESCENCE SPECTROSCOPY; GEL ELECTROPHORESIS; INFRARED RADIATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; SPECTROSCOPY; VALIDATION PROCESS;

ABSORPTION; ANIMALS; BENZYL COMPOUNDS; CATTLE; COPPER; DNA; DNA TOPOISOMERASES, TYPE II; ELECTROCHEMISTRY; HUMANS; ORGANOMETALLIC COMPOUNDS; REPRODUCIBILITY OF RESULTS; SPECTRUM ANALYSIS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TOPOISOMERASE II INHIBITORS;

EID: 79959919710     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20970     Document Type: Article

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