A mechanistic approach for the DNA binding of chiral enantiomeric L - And D -tryptophan-derived metal complexes of 1,2-DACH: Cleavage and antitumor activity

Chirality

Volumn 23, Issue 3, 2011, Pages 250-259

  Arjmand, Farukh ^a   Muddassir, Mohd ^a  

^a ALIGARH MUSLIM UNIVERSITY   (India)

Author keywords

1,2 DACH; antitumor activity; chiral recognition; circular dichroism; fluorescence studies; UV vis titration

Indexed keywords

1,2 DACH; 3 MERCAPTOPROPIONIC ACID; ASCORBIC ACID; COBALT; COPPER ION; GLUTATHIONE; HYDROGEN PEROXIDE; METAL COMPLEX; NUCLEIC ACID BASE; TRYPTOPHAN; UNCLASSIFIED DRUG; ZINC ION;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CARCINOMA CELL; CHIRALITY; DNA BINDING; DNA CLEAVAGE; DRUG SCREENING; DRUG SYNTHESIS; ELECTRON SPIN RESONANCE; ENANTIOMER; FLUORESCENCE; HISTOLOGY; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; PANCREAS CANCER; PRIORITY JOURNAL; STEADY STATE; X RAY DIFFRACTION;

5'-GUANYLIC ACID; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL SURVIVAL; CIRCULAR DICHROISM; COORDINATION COMPLEXES; COPPER; CYCLOHEXYLAMINES; DNA; DNA CLEAVAGE; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; ORGANOMERCURY COMPOUNDS; REACTIVE OXYGEN SPECIES; SPECTROPHOTOMETRY, INFRARED; STEREOISOMERISM; THYMIDINE MONOPHOSPHATE; TRYPTOPHAN; X-RAY DIFFRACTION;

EID: 79951506524     PISSN: 08990042     EISSN: 1520636X     Source Type: Journal    
DOI: 10.1002/chir.20907     Document Type: Article

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