Genetic control of resistance to Trypanosoma brucei brucei infection in mice

PLoS Neglected Tropical Diseases

Volumn 5, Issue 6, 2011, Pages

  Šíma, Matyáš ^a   Havelková, Helena ^a   Quan, Lei ^b   Svobodová, Milena ^c   Jarošíková, Taťána ^d   Vojtíšková, Jarmila ^a   Stassen, Alphons P M ^e   Demant, Peter ^b   Lipoldová, Marie ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b ROSWELL PARK CANCER INSTITUTE   (United States)

^c CHARLES UNIVERSITY   (Czech Republic)

^d CZECH TECHNICAL UNIVERSITY IN PRAGUE   (Czech Republic)

^e MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ARTICLE; BAGG ALBINO MOUSE; CHROMOSOME 12; CHROMOSOME 19; CHROMOSOME 3; CHROMOSOME 7; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENE MAPPING; GENETIC REGULATION; GENETIC VARIABILITY; HYBRID; INFECTION RESISTANCE; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; STRAIN DIFFERENCE; SURVIVAL; TBBR GENE; TBBR1 GENE; TBBR2 GENE; TBBR3 GENE; TBBR4 GENE; TRYPANOSOMA BRUCEI; ANIMAL; CHROMOSOME MAP; CROSS BREEDING; GENETICS; GENOTYPE; IMMUNOLOGY; INNATE IMMUNITY; PATHOGENICITY; RODENT DISEASE;

ANIMALS; CHROMOSOME MAPPING; CROSSES, GENETIC; FEMALE; GENETIC LOCI; GENOTYPE; IMMUNITY, INNATE; MALE; MICE; MICE, INBRED BALB C; RODENT DISEASES; SURVIVAL ANALYSIS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 79959908537     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001173     Document Type: Article

References (66)

1. Aksoy S, Gibson WC, Lehane MJ, (2003) Interactions between tsetse and trypanosomes with implications for the control of trypanosomiasis. Adv Parasitol 53: 1-83.
2. Vanhamme L, Paturiaux-Hanocq F, Poelvoorde P, Nolan DP, Lins L, et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum. Nature 422: 83-87.
3. Wheeler RJ, (2010) The trypanolytic factor-mechanism, impacts and applications. Trends Parasitol 26: 457-464.
4. Lai DH, Hashimi H, Lun ZR, Ayala FJ, Lukes J, (2008) Adaptations of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei. Proc Natl Acad Sci U S A 105: 1999-2004.
5. Vincendeau P, Bouteille B, (2006) Immunology and immunopathology of African trypanosomiasis. An Acad Bras Cienc 78: 645-665.
6. Tabel H, Wei G, Shi M, (2008) T cells and immunopathogenesis of experimental African trypanosomiasis. Immunol Rev 225: 128-139.
7. Masocha W, Amin DN, Kristensson K, Rottenberg ME, (2008) Differential invasion of Trypanosoma brucei brucei and lymphocytes into the brain of C57BL/6 and 129Sv/Ev mice. Scand J Immunol 68: 484-491.
8. Marcello L, Barry JD, (2007) Analysis of the VSG gene silent archive in Trypanosoma brucei reveals that mosaic gene expression is prominent in antigenic variation and is favored by archive substructure. Genome Res 17: 1344-1352.
9. Rickman WJ, Cox HW, (1980) Immunologic reactions associated with anemia, thrombocytopenia, and coagulopathy in experimental African trypanosomiasis. J Parasitol 66: 28-33.
10. Coller SP, Mansfield JM, Paulnock DM, (2003) Glycosylinositolphosphate soluble variant surface glycoprotein inhibits IFN-gamma-induced nitric oxide production via reduction in STAT1 phosphorylation in African trypanosomiasis. J Immunol 171: 1466-1472.
11. Diffley P, (1983) Trypanosomal surface coat variant antigen causes polyclonal lymphocyte activation. J Immunol 131: 1983-1986.
12. Darji A, Beschin A, Sileghem M, Heremans H, Brys L, et al. (1996) In vitro simulation of immunosuppression caused by Trypanosoma brucei: active involvement of gamma interferon and tumor necrosis factor in the pathway of suppression. Infect Immun 64: 1937-1943.
13. Courtin D, Jamonneau V, Mathieu JF, Koffi M, Milet J, et al. (2006) Comparison of cytokine plasma levels in human African trypanosomiasis. Trop Med Int Health 11: 647-653.
14. Black SJ, Sendashonga CN, Lalor PA, Whitelaw DD, Jack RM, et al. (1983) Regulation of the growth and differentiation of Trypanosoma (Trypanozoon) brucei brucei in resistant (C57BL/6) and susceptible (C3H/He) mice. Parasite Immunol 5: 465-478.
15. van Velthuysen ML, Veninga A, Bruijn JA, de Heer E, Fleuren GJ, (1993) Susceptibility for infection-related glomerulopathy depends on non-MHC genes. Kidney Int 43: 623-629.
16. Magez S, Truyens C, Merimi M, Radwanska M, Stijlemans B, et al. (2004) P75 tumor necrosis factor-receptor shedding occurs as a protective host response during African trypanosomiasis. J Infect Dis 189: 527-539.
17. Gershon RK, Kondo K, (1976) Deficient production of a thymus-dependent high affinity antibody subset in mice (CBA/N) with an X-linked B lymphocyte defect. J Immunol 117: 701-702.
18. Gasbarre LC, Finerty JF, Louis JA, (1981) Non-specific immune responses in CBA/N mice infected with Trypanosoma brucei. Parasite Immunol 3: 273-282.
19. Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ, (1997) Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet 16: 194-196.
20. Iraqi F, Clapcott SJ, Kumari P, Haley CS, Kemp SJ, et al. (2000) Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mamm Genome 11: 645-648.
21. Goodhead I, Archibald A, Amwayi P, Brass A, Gibson J, et al. (2010) A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Negl Trop Dis4: e880.
22. Nganga JK, Soller M, Iraqi FA, (2010) High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele. BMC Genomics 11: 394.
23. Graefe SE, Meyer BS, Muller-Myhsok B, Ruschendorf F, Drosten C, et al. (2003) Murine susceptibility to Chagas' disease maps to chromosomes 5 and 17. Genes Immun 4: 321-325.
24. Demant P, Hart AA, (1986) Recombinant congenic strains-a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24: 416-422.
25. Van Wezel T, Lipoldová M, Demant, Editors: Malcolm S P, Goodship J, (2001) Identification of disease susceptibility genes (modifiers) in mouse models: cancer and infectious diseases. Genotype to Phenotype second edition Oxford BIOS Scientific Publishers Ltd pp. 107-129.
26. Demant P, Lipoldová M, Svobodová M, (1996) Resistance to Leishmania major in mice. Science 274: 1392a.
27. Lipoldová M, Svobodová M, Krulová M, Havelková H, Badalová J, et al. (2000) Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Genes Immun 1: 200-206.
28. Havelková H, Badalová J, Svobodová M, Vojtíšková J, Kurey I, et al. (2006) Genetics of susceptibility to leishmaniasis in mice: four novel loci and functional heterogeneity of gene effects. Genes Immun 7: 220-233.
29. Lipoldová M, Demant P, (2006) Genetic susceptibility to infectious disease: lessons from mouse models of leishmaniasis. Nat Rev Genet 7: 294-305.
30. Vladimirov V, Badalová J, Svobodová M, Havelková H, Hart AA, et al. (2003) Different genetic control of cutaneous and visceral disease after Leishmania major infection in mice. Infect Immun 71: 2041-2046.
31. Banus HA, van Kranen HJ, Mooi FR, Hoebee B, Nagelkerke NJ, et al. (2005) Genetic control of Bordetella pertussis infection: identification of susceptibility loci using recombinant congenic strains of mice. Infect Immun 73: 741-747.
32. Stassen AP, Groot PC, Eppig JT, Demant P, (1996) Genetic composition of the recombinant congenic strains. Mamm Genome 7: 55-58.
33. Tripodis N, Demant P, (2001) Three-dimensional patterns of lung tumor growth: association with tumor heterogeneity. Exp Lung Res 27: 521-531.
34. Lander ES, Schork NJ, (1994) Genetic dissection of complex traits. Science 265: 2037-2048.
35. Kurey I, Kobets T, Havelková H, Slapničková M, Quan L, et al. (2009) Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection. Immunogenetics 61: 619-633.
36. Frankel WN, Schork NJ, (1996) Who's afraid of epistasis? Nat Genet 14: 371-373.
37. Hanotte O, Ronin Y, Agaba M, Nilsson P, Gelhaus A, et al. (2003) Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. Proc Natl Acad Sci U S A 100: 7443-7448.
38. Havelková H, Badalová J, Demant P, Lipoldová M, (2000) A new type of genetic regulation of allogeneic response. A novel locus on mouse chromosome 4, Alan2 controls MLC reactivity to three different alloantigens: C57BL/10, BALB/c and CBA. Genes Immun 1: 483-487.
39. Lipoldová M, Svobodová M, Havelková H, Krulová M, Badalová J, et al. (2002) Mouse genetic model for clinical and immunological heterogeneity of leishmaniasis. Immunogenetics 54: 174-183.
40. Shockley KR, Churchill GA, (2006) Gene expression analysis of mouse chromosome substitution strains. Mamm Genome 17: 598-614.
41. Li R, Lyons MA, Wittenburg H, Paigen B, Churchill GA, (2005) Combining data from multiple inbred line crosses improves the power and resolution of quantitative trait loci mapping. Genetics 169: 1699-1709.
42. Moen CJ, Stoffers HJ, Hart AA, Westerhoff HV, Demant P, (1997) Simulation of the distribution of parental strains' genomes in RC strains of mice. Mamm Genome 8: 884-889.
43. Badalová J, Svobodová M, Havelková H, Vladimirov V, Vojtíšková J, et al. (2002) Separation and mapping of multiple genes that control IgE level in Leishmania major infected mice. Genes Immun 3: 187-195.
44. Gusareva ES, Havelková H, Blažková H, Kosařová M, Kučera P, et al. (2009) Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12. Immunogenetics 61: 15-25.
45. Alexander J, Irving K, Snider H, Satoskar A Editors: Klein SL, Roberts CW, (2010) Sex hormones of host responses against parasites. Heildelberg, Dordrecht, London, New York pp. 147-186.
46. Yeretssian G, Doiron K, Shao W, Leavitt BR, Hayden MR, et al. (2009) Gender differences in expression of the human caspase-12 long variant determines susceptibility to Listeria monocytogenes infection. Proc Natl Acad Sci U S A 106: 9016-9020.
47. Greenblatt HC, Rosenstreich DL, (1984) Trypanosoma rhodesiense infection in mice: sex dependence of resistance. Infect Immun 43: 337-340.
48. Brownstein DG, Gras L, (1995) Chromosome mapping of Rmp-4, a gonad-dependent gene encoding host resistance to mousepox. J Virol 69: 6958-6964.
49. Lundberg P, Welander P, Openshaw H, Nalbandian C, Edwards C, et al. (2003) A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice. J Virol 77: 11661-11673.
50. Butterfield RJ, Roper RJ, Rhein DM, Melvold RW, Haynes L, et al. (2003) Sex-specific quantitative trait loci govern susceptibility to Theiler's murine encephalomyelitis virus-induced demyelination. Genetics 163: 1041-1046.
51. Carroll SF, Loredo Osti JC, Guillot L, Morgan K, Qureshi ST, (2008) Sex differences in the genetic architecture of susceptibility to Cryptococcus neoformans pulmonary infection. Genes Immun 9: 536-545.
52. Min-Oo G, Lindqvist L, Vaglenov A, Wang C, Fortin P, et al. (2008) Genetic control of susceptibility to pulmonary infection with Chlamydia pneumoniae in the mouse. Genes Immun 9: 383-388.
53. Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, et al. (2010) Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls. Pediatr Pulmonol 45: 608-613.
54. Gamper CJ, Agoston AT, Nelson WG, Powell JD, (2009) Identification of DNA methyltransferase 3a as a T cell receptor-induced regulator of Th1 and Th2 differentiation. J Immunol 183: 2267-2276.
55. Dagenais TR, Freeman BE, Demick KP, Paulnock DM, Mansfield JM, (2009) Processing and presentation of variant surface glycoprotein molecules to T cells in African trypanosomiasis. J Immunol 183: 3344-3355.
56. Catania A, (2007) The melanocortin system in leukocyte biology. J Leukoc Biol 81: 383-392.
57. Bicknell AB, (2008) The tissue-specific processing of pro-opiomelanocortin. J Neuroendocrinol 20: 692-699.
58. Tasken K, Stokka AJ, (2006) The molecular machinery for cAMP-dependent immunomodulation in T-cells. Biochem Soc Trans 34: 476-479.
59. Xu J, Wu RC, O'Malley BW, (2009) Normal and cancer-related functions of the p160 steroid receptor co-activator (SRC) family. Nat Rev Cancer 9: 615-630.
60. Schleifer KW, Mansfield JM, (1993) Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins. J Immunol 151: 5492-5503.
61. Dorshkind K, Montecino-Rodriguez E, (2007) Fetal B-cell lymphopoiesis and the emergence of B-1-cell potential. Nat Rev Immunol 7: 213-219.
62. Dutra WO, Colley DG, Pinto-Dias JC, Gazzinelli G, Brener Z, et al. (2000) Self and nonself stimulatory molecules induce preferential expansion of CD5+ B cells or activated T cells of chagasic patients, respectively. Scand J Immunol 51: 91-97.
63. Onah DN, Hopkins J, Luckins AG, (1998) Increase in CD5+ B cells and depression of immune responses in sheep infected with Trypanosoma evansi. Vet Immunol Immunopathol 63: 209-222.
64. Buza J, Sileghem M, Gwakisa P, Naessens J, (1997) CD5+ B lymphocytes are the main source of antibodies reactive with non-parasite antigens in Trypanosoma congolense-infected cattle. Immunology 92: 226-233.
65. Taft RJ, Pang KC, Mercer TR, Dinger M, Mattick JS, (2010) Non-coding RNAs: regulators of disease. J Pathol 220: 126-139.
66. Roy MF, Riendeau N, Loredo-Osti JC, Malo D, (2006) Complexity in the host response to Salmonella typhimurium infection in AcB and BcA recombinant congenic strains. Genes Immun 7: 655-666.