High resolution mapping of trypanosomosis resistance loci Tir2 and Tir3 using F12 advanced intercross lines with major locus Tir1 fixed for the susceptible allele

BMC Genomics

Volumn 11, Issue 1, 2010, Pages

  Nganga, Joseph K ^a,b   Soller, Morris ^c   Iraqi, Fuad A ^a,d  

^a INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE   (Kenya)

^b JOMO KENYATTA UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Kenya)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED INTERCROSS LINE; ANIMAL TISSUE; ARTICLE; C57BL 6 MOUSE; CONTROLLED STUDY; FEMALE; GENE LOCUS; GENETIC SUSCEPTIBILITY; GENOTYPE; INFECTION SENSITIVITY; MALE; MICROSATELLITE MARKER; MOUSE; NAGANA; NONHUMAN; PLEIOTROPY; POPULATION GENETICS; QUANTITATIVE TRAIT LOCUS MAPPING; SURVIVAL TIME; TRYPANOSOMA CONGOLENSE; ALLELE; ANIMAL; CHROMOSOME MAP; GENETIC PREDISPOSITION; GENETIC RECOMBINATION; GENETICS; HYBRIDIZATION; IMMUNOLOGY; INNATE IMMUNITY; QUANTITATIVE TRAIT LOCUS; TRYPANOSOMIASIS;

BOS; MUS;

MICROSATELLITE DNA;

ALLELES; ANIMALS; CHROMOSOME MAPPING; FEMALE; GENETIC LOCI; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HYBRIDIZATION, GENETIC; IMMUNITY, INNATE; MALE; MICE; MICROSATELLITE REPEATS; QUANTITATIVE TRAIT LOCI; RECOMBINATION, GENETIC; TRYPANOSOMIASIS;

EID: 77953677504     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-11-394     Document Type: Article

References (27)

1. World Health Organization. Tropical Disease Research Thirteenth Programme Report. UNDP/World Bank/WHO Special Programme for Research and Training in Tropical Disease (TDR) 1997, 125-126. World Health Organization. Tropical Disease Research.
2. World Health Organization Control and surveillance of African trypanosomiasis. Report of a WHO Expert Committee. World Health Organ Tech Rep Ser 1998, 881:I-VI. 1-114, World Health Organization.
3. Murray M, Dexter TM. Anaemia in bovine African trypanosomiasis. Acta Trop 1988, 45:389-432.
4. Gardiner PR, Assoku RK, Whitelaw DD, Murray M. Haemorrhagic lesions resulting from Trypanosoma vivax infection in Ayrshire cattle. Vet Parasitol 1989, 31:187-197. 10.1016/0304-4017(89)90069-1, 2763442.
5. Roelants GE, Fumoux F, Pinder M, Queval R, Bassinga A, Authie E. Identification and selection of cattle naturally resistant to African trypanosomiasis. Acta Trop 1987, 44:55-66.
6. Hanotte O, Ronin Y, Agaba M, Gelhaus A, Horstmann R, Sugimoto Y, Kemp S, Gibson J, Korol A, Soller M, Teale A. Mapping of quantitative trait loci controlling trypanotolerance in a cross of tolerant West African N'Dama and susceptible East African Boran cattle. Proc Natl Acad Sci USA 2003, 100:7443-7448. 10.1073/pnas.1232392100, 164605, 12805560.
7. Kemp SJ, Darvasi A, Soller M, Teale AJ. Genetic control of resistance to trypanosomiasis. Veterinary Immunology and Immunopathology 1996, 54:239-243. 10.1016/S0165-2427(96)05692-9, 8988870.
8. Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ. Localization of genes controlling resistance to trypanosomiasis in mice. Nat Genet 1997, 16:194-196. 10.1038/ng0697-194, 9171834.
9. Moore KJ, Nagle DL. Complex trait analysis in the mouse: The strengths, the limitations and the promise yet to come. Annu Rev Genet 2000, 34:653-686. 10.1146/annurev.genet.34.1.653, 11092842.
10. Morrison WI, Roelants GE, Mayor-Withey KS, Murray M. Susceptibility of inbred strains of mice to Trypanosoma congolense: correlation with changes in spleen lymphocyte populations. Clin Exp Immunol 1978, 32:25-40. 1541310, 307464.
11. Noyes HA, Alimohammadian MH, Agaba M, Brass A, Fuchs H, Gailus-Durner V, Hulme H, Iraqi FA, Kemp SJ, Rathkolb B, Wolf E, Hrabé de Angelis M, Roshandel D, Naessens J. Mechanisms controlling anaemia in Trypanosoma congolense infected mice. PLOS One 2009, 4(4):e5170. 10.1371/journal.pone.0005170, 2664899, 19365556.
12. Whitelaw DD, Holmes PH, Urquhart GM. The susceptibility of strains of mice to infection with Trypanosoma congolense. Res Vet Sci 1978, 25:399-400.
13. Murray M, Gray RA. The current situation in animal trypanosomosis in Africa. Preventive Veterinary Medicine 1984, 2:23-30.
14. Whitelaw DD, Macaskill JA, Holmes PH, Jennings FW, Urquhart GM. Genetic resistance to Trypanosoma congolense infections in mice. Infect Immun 1980, 27:707-713. 550831, 7380550.
15. Darvasi A, Soller M. Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 1995, 141:1199-1207. 1206841, 8582624.
16. Iraqi F, Clapcott SJ, Kumari P, Haley CS, Kemp SJ, Teale AJ. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines. Mammalian Genome 2000, 11:645-648. 10.1007/s003350010133, 10920233.
17. Darvasi A, Soller M. Selective genotyping for determination of linkage between a marker locus and a quantitative trait locus. Theoretical and applied Genetics 1992, 85:353-359.
18. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genetics1 1994, 38:963-971.
19. Clapcott S. Localization of Genes Controlling Resistance to Trypanosomiasis in Mice (Mus musculus L.). PhD thesis 1998, Conducted at the University of Liverpool, UK.
20. Darvasi A. Interval specific congenic strains (ISCS): an experimental design for mapping a QTL into a 1-centimorgan interval. Mammalian Genome 1997, 8:163-167. 10.1007/s003359900382, 9069114.
21. Fehr C, Shirley R, Belknap JK, Crabbel JC, Buck KJ. Congenic Mapping of Alcohol and Pentobarbital Withdrawal Liability Loci to a <1 Centimorgan Interval of Murine Chromosome 4: Identification of Mpdz as a Candidate Gene. The Journal of Neuroscience 2002, 22:3730-3738.
22. Baguet A, Epler J, Wen KW, Bix M. A Leishmania major Response Locus Identified by Interval-specific Congenic Mapping of a T Helper Type 2 Cell Bias-controlling Quantitative Trait Locus. Journal of Experimental Medicine 2004, 200:1605-1612. 10.1084/jem.20040334, 2211989, 15596523.
23. Crabbe JC, Dudek BC. Genetics of mouse behavior, interactions with laboratory environment. Science 1999, 284:1670-1672. 10.1126/science.284.5420.1670, 10356397.
24. Sambrook J, Fritsch EF, Maniatis T. Molecular Cloning a Laboratory Manual. 1989, Cold Spring Harbor Laboratory Press, NY.
25. Kruglyak L, Lander ES. A nonparametric approach for mapping quantitative trait loci. Genetics 1995, 139:1421-1428. 1206467, 7768449.
26. Haley CS, Knott SA. A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 1992, 69:315-324.
27. Ronin YI, Korol AB, Weller JI. Selective genotyping to detect quantitative trait lociaffecting multiple traits: interval mapping analysis. Theoretical and Applied Genetics 1998, 97:1169-1178.