Susceptibility to Leishmania major infection in mice: Multiple loci and heterogeneity of immunopathological phenotypes

Genes and Immunity

Volumn 1, Issue 3, 2000, Pages 200-206

  Lipoldova M ^a   Svobodova M ^b   Krulova M ^a   Havelkova H ^a   Badalova J ^a   Nohynkova E ^b   Holan V ^a   Hart, Aam ^c   Volf, P ^b   Demant, P ^c  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

Author keywords

Genetic control; Immune response; Leishmania major; Pathology; Th1 Th2 paradigm

Indexed keywords

LEISHMANIA MAJOR;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; C57BL MOUSE; COMPARATIVE STUDY; CONGENIC STRAIN; FEMALE; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETICS; GENOTYPE; HYBRIDIZATION; IMMUNOLOGY; IN VITRO STUDY; LEISHMANIA MAJOR; LYMPHOCYTE ACTIVATION; MOUSE; MOUSE STRAIN; PATHOLOGY; PHENOTYPE; SKIN LEISHMANIASIS; SPECIES DIFFERENCE; TH1 CELL; TH2 CELL;

ANIMALS; ANIMALS, CONGENIC; FEMALE; GENOTYPE; HYBRIDIZATION, GENETIC; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; LINKAGE (GENETICS); LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED STRAINS; PHENOTYPE; POLYMORPHISM, GENETIC; SPECIES SPECIFICITY; TH1 CELLS; TH2 CELLS;

EID: 0034139626     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6363660     Document Type: Article

References (37)

1. Reiner SL, Locksley RM. The regulation of immunity to Leishmania major. Annu Rev Immunol 1995; 13: 151-177.
2. Bogdan C, Gessner A, Sollbach W, Röllinghoff M. Invasion, control and persistence of Leishmania parasites. Curr Opin Immunol 1996; 8: 517-525.
3. + T cells in leishmaniasis. Immunol Today 1989; 10: 40-45.
4. Phillips SM. Mechanisms of immunopathology in parasitic infections. In: Warren KS. Immunology and Molecular Biology of Parasitic Infections. Blackwell Scientific Publication, Boston, Oxford, London, Edinburgh, Melbourne, Paris, Berlin, Vienna. 1993, pp 52-86.
5. + T cell subsets and induces early resistance to Leishmania major in mice. J Exp Med 1993; 178: 567-578.
6. Launois P, Swihart KG, Milon G, Louis JA. Early production of IL-4 in susceptible mice infected with Leishmania major rapidly induces IL-12 unresponsiveness. J Immunol 1997; 158: 3317-3324.
7. Diefenbach A, Schindler H, Donhauser N et al. Type 1 interferon (IFNα/β) and type 2 nitric oxide synthase regulate the innate immune response to a protozoan parasite. Immunity 1998; 8: 77-78.
8. Demant P, Lipoldová M, Svobodová M. Resistance to Leishmania major in mice (technical comment). Science 1996; 274: 1392.
9. Beebe AM, Mauze S, Schork NJ, Coffman RL. Serial backcross mapping of multiple loci associated with resistance to Leishmania major in mice. Immunity 1997; 6: 551-557.
10. Roberts LJ, Baldwin TM, Curtis JM, Handman E, Foote SJ. Resistance to Leishmania major is linked to H2 region on chromosome 17 and to chromosome 9. J Exp Med 1997; 9: 1705-1710.
11. Demant P, Hart AAM. Recombinant congenic strains: a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 1986; 24: 416-422.
12. Roberts M, Mock BA, Blackwell JM. Mapping of genes controlling Leishmania major infection in CXS recombinant inbred mice. Eur J Immunogenet 1993; 20: 349-362.
13. Aebischer T, Moody SF, Handman E. Persistence of virulent Leishmania major in murine cutaneous leishmaniasis: a possible hazard for the host. Infect Immun 1993; 16: 220-226.
14. Stassen APM, Groot PC, Eppig JT, Demant P. Genetic composition of the recombinant congenic strains. Mamm Genome 1996; 7: 55-58.
15. Kemp SJ, Iraqi F, Darvasi A, Soller M, Teale AJ. Localization of genes controlling resistance to trypanosomiasis in mice. Nature Genet 1997; 16: 194-196.
16. Hoerauf A, Solbach W, Röllinghoff M, Gessner A. Effect of IL-7 treatment on Leishmania major-infected BALB.XId mice: enhanced lymphopoesis with sustained lack of B1 cells and clinical aggravation of disease. Int Immunol 1995; 7: 1879-1884.
17. Garcia I, Miyazaki Y, Araki K, et al. Transgenic mice expressing high levels of soluble TNF-R1 fusion protein are protected from lethal septic shock and cerebral malaria, and are highly sensitive to Listeria monocytogenes and Leishmania major infections. Eur J Immunol 1995; 25: 2401-2407.
18. + effector cells default to the Th2 pathway in interferon-deficient mice infected with Leishmania major. J Exp Med 1994; 179: 1367-1371.
19. Shimoda K, van Deursen J, Sangster MY et al. Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996; 380: 630-633.
20. Moen CJA, Groot PC, Hart AAM, Snoek M, Demant P. Fine mapping of colon tumor susceptibility (Scc) genes in the mouse, different from the genes known to be somatically mutated in colon cancer. Proc Natl Acad Sci USA 1996; 93: 1082-1086.
21. H1 cell development. Science 1996; 271: 984-987.
22. Kopf M, Le Gros G, Coyle AJ, Kosco-Vilboa M, Brombacher F. Immune responses of IL-4, IL-5, IL-6 deficient mice. Immunol Rev 1995; 148: 45-69.
23. Shanebeck KD, Maliszewski CR, Kennedy MK et al. Regulation of murine B cell growth and differentiation by CD30 ligand. Eur J Immunol 1995; 25: 2147-2153.
24. Coffman RL, Carty J. A T-cell activity that enhances polyclonal IgE production and its inhibition by interferon-γ. J Immunol 1986; 136: 949-954.
25. Sutton BJ, Gould HJ. The human IgE network. Nature 1993; 366: 421-428.
26. Holgate ST. Asthma genetics: waiting to exhale. Nature Genet 1997; 15: 227-229.
27. Marsh DG, Neely JD, Breazeale DR et at. Linkage analysis of IL-4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 1994; 264: 1152-1156.
28. Barnes KC, Neely JD, Duffy DL et al. Linkage of asthma and total serum IgE concentration to arkers on chromosome 12q: evidence from Afro-Caribbean and Caucasian population. Genomics 1996; 34: 41-45.
29. Bix M, Wang ZE, Thiel B, Schork NJ, Locksley RM. Genetic regulation of commitment to Interleukin 4 production by a CD4+ T-cell-intrinsic mechanism. J Exp Med 1998; 188: 2289-2299.
30. Taylor AER, Baker JR. The Cultivation of Parasites in vitro. Blackwell Scientific Publications, Oxford and Edinburgh, 1968.
31. Diamond LS, Herman CM. Incidence of trypanosomes in the Canada goose as revealed by bone marrow culture. J Parasitol 1954; 40: 195-202.
32. Control of the leishmanioses. Technical Report Series 793, WHO 1990.
33. Lipoldová M, Kosařová M, Zajícová A et al. Separation of multiple genes controlling the T-cell proliferative response to IL-2 and anti-CD3 using recombinant congenic strains. Immunogenetics 1995; 41: 301-311.
34. Chirgwin JM, Przybyla AE, MacDonald RJ, Rutter JW. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry 1979; 24: 5294-5299.
35. Laird P, Zijderveld A, Linders K, Rudnicky MA, Jaenisch R, Berns A. Simplified mammalian DNA isolation procedure. Nucleic Acids Res 1991; 19: 4293.
36. Krulová M, Havelková H, Kosařová M et al. IL-2-induced proliferative response is controlled by loci Cinda1 and Cinda2 on mouse chromosomes 11 and 12. A distinct control of the response induced by different IL-2 concentrations. Genomics 1997; 41: 11-15.
37. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting results. Nature Genet 1995; 11: 241-247.