Proteolytic processing of the γ-subunit is associated with the failure to form GlcNAc-1-phosphotransferase complexes and mannose 6-phosphate residues on lysosomal enzymes in human macrophages

Journal of Biological Chemistry

Volumn 285, Issue 31, 2010, Pages 23936-23944

  Pohl, Sandra ^a   Tiede, Stephan ^a,c   Marschner, Katrin ^a   Encarnação, Marisa ^a   Castrichini, Monica ^a,d   Kollmann, Katrin ^a   Muschol, Nicole ^a   Ullrich, Kurt ^a   Müller Loennies, Sven ^b   Braulke, Thomas ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b RESEARCH CENTER BORSTEL   (Germany)

^c UNIVERSITY OF LÜBECK   (Germany)

^d UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN D; HELA CELL; HUMAN MACROPHAGES; LYSOSOMAL ENZYMES; MOLECULAR COMPLEXES; MRNA LEVEL; PHOSPHOTRANSFERASES; PROTEIN LEVEL; PROTEOLYTIC PROCESSING; REAL-TIME PCR;

CATALYSTS; CELL CULTURE; ENZYME ACTIVITY; ENZYMES; OLIGOMERS; SIZE EXCLUSION CHROMATOGRAPHY;

MACROPHAGES;

CATHEPSIN D; LYSOSOME ENZYME; MANNOSE 6 PHOSPHATE; N ACETYGLUCOSAMINE 1 PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; EXPRESSION VECTOR; FIBROBLAST; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; GOLGI COMPLEX; HELA CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MACROPHAGE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; PROTEIN SYNTHESIS; PROTEIN TARGETING; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL TRANSPORT; CATHEPSIN D; CERCOPITHECUS AETHIOPS; CHROMATOGRAPHY; COS CELLS; HELA CELLS; HUMANS; LYSOSOMES; MACROPHAGES; MANNOSEPHOSPHATES; MODELS, BIOLOGICAL; PROTEIN BINDING; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFERASES (OTHER SUBSTITUTED PHOSPHATE GROUPS);

EID: 77954897974     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.129684     Document Type: Article

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