Targeting the proteolytic processing of the viral glycoprotein precursor is a promising novel antiviral strategy against arenaviruses

Journal of Virology

Volumn 84, Issue 1, 2010, Pages 573-584

  Rojek, Jillian M ^a   Pasqual, Giulia ^b   Sanchez, Ana B ^c   Nguyen, Ngoc Thao ^a   De La Torre, Juan Carlos ^a   Kunz, Stefan ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; DECANOYL ARGINYLARGINYLLEUCYLLEUCYL CHLOROMETHYLKETONE; DECANOYL ARGINYLVALYLLYSYLARGINYL CHLOROMETHYLKETONE; FURIN; PEPTIDE DERIVATIVE; PROTEINASE INHIBITOR; RIBAVIRIN; SERINE PROTEINASE; SERINE PROTEINASE INHIBITOR; SITE 1 PROTEASE; UNCLASSIFIED DRUG; VIRUS ENZYME;

ANIMAL CELL; ANTIVIRAL ACTIVITY; ANTIVIRAL THERAPY; ARENAVIRUS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; DRUG POTENCY; DRUG TARGETING; EMBRYO; HUMAN; HUMAN CELL; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN MOTIF; PROTEIN TARGETING; VIRAL GENETICS; VIRUS MENINGITIS; VIRUS MUTANT; VIRUS TITRATION;

ANIMALS; ANTIVIRAL AGENTS; ARENAVIRUS; CELL LINE; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; GLYCOPROTEINS; HUMANS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; PEPTIDE HYDROLASES; PEPTIDES; PROPROTEIN CONVERTASES; PROTEASE INHIBITORS; RIBAVIRIN; SERINE ENDOPEPTIDASES; VIRAL ENVELOPE PROTEINS;

ARENAVIRUS; LYMPHOCYTIC CHORIOMENINGITIS VIRUS;

EID: 72849146137     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.01697-09     Document Type: Article

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