Combined Oral Contraceptive Pills Containing Desogestrel or Drospirenone Enhance Large Vessel and Microvasculature Vasodilation in Healthy Premenopausal Women

Microcirculation

Volumn 18, Issue 5, 2011, Pages 339-346

  Thompson, Abby K ^a   Przemska, Agnieszka ^a   Vasilopoulou, Dafni ^a   Newens, Katie J ^a   Williams, Christine M ^a  

^a UNIVERSITY OF READING   (United Kingdom)

Author keywords

Arterial stiffness; Combined oral contraceptive; Endothelial function; Estradiol; Progestin

Indexed keywords

DESOGESTREL; DESOGESTREL PLUS ETHINYLESTRADIOL; DROSPIRENONE; DROSPIRENONE PLUS ETHINYLESTRADIOL; ETHINYLESTRADIOL; ETHINYLESTRADIOL PLUS LEVONORGESTREL; GESTAGEN; LEVONORGESTREL; ORAL CONTRACEPTIVE AGENT;

ADULT; ARTERIAL STIFFNESS; ARTICLE; BLOOD VESSEL; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; FEMALE; HORMONAL CONTRACEPTION; HUMAN; HUMAN EXPERIMENT; MENSTRUAL CYCLE; MICROVASCULATURE; NORMAL HUMAN; ORAL CONTRACEPTION; PILL; PREMENOPAUSE; PRIORITY JOURNAL; RISK FACTOR; TREATMENT DURATION; VASCULAR DISEASE; VASODILATATION;

ADULT; ALDOSTERONE ANTAGONISTS; ANDROSTENES; CONTRACEPTIVES, ORAL, SYNTHETIC; DESOGESTREL; ENDOTHELIUM, VASCULAR; ESTROGENS; ETHINYL ESTRADIOL; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MENSTRUAL CYCLE; NITRIC OXIDE SYNTHASE TYPE III; TIME FACTORS; VASODILATION;

EID: 79959849963     PISSN: 10739688     EISSN: 15498719     Source Type: Journal    
DOI: 10.1111/j.1549-8719.2011.00094.x     Document Type: Article

References (48)

1. Anderson TJ, Elstein E, Haber H, Charbonneau F. Comparative study of ACE-inhibition, angiotensin II antagonism, and calcium channel blockade on flow-mediated vasodilation in patients with coronary disease (BANFF study). J Am Coll Cardiol 35: 60-66, 2000.
2. Arnal JF, Gourdy P, Simoncini T. Interference of progestins with endothelial actions of estrogens: a matter of glucocorticoid action or deprivation? Arterioscler Thromb Vasc Biol 29: 441-443, 2009.
3. Barrett-Connor E. An epidemiologist looks at hormones and heart disease in women. J Clin Endocrinol Metab 88: 4031-4042, 2003.
4. Bruce RC, Howard O. Estrogen and progestin components of oral contraceptives: relationship to vascular disease. Contraception 55: 267-272, 1997.
5. Chan NN, MacAllister RJ, Colhoun HM, Vallance P, Hingorani AD. Changes in endothelium-dependent vasodilatation and alpha-adrenergic responses in resistance vessels during the menstrual cycle in healthy women. J Clin Endocrinol Metab 86: 2499-2504, 2001.
6. Cooke JP, Dzau VJ. Nitric oxide synthase: role in the genesis of vascular disease. Annu Rev Med 48: 489-509, 1997.
7. Corretti MC, Anderson TJ, Benjamin EJ, Celermajer D, Charbonneau F, Creager MA, Deanfield J, Drexler H, Gerhard-Herman M, Herrington D, Vallance P, Vita J, Vogel R. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 39: 257-265, 2002.
8. Donald AE, Halcox JP, Charakida M, Storry C, Wallace SM, Cole TJ, Friberg P, Deanfield JE. Methodological approaches to optimize reproducibility and power in clinical studies of flow-mediated dilation. J Am Coll Cardiol 51: 1959-1964, 2008.
9. Dupuis J, Tardif J-C, Cernacek P, Theroux P. Cholesterol reduction rapidly improves endothelial function after acute coronary syndromes: the RECIFE (Reduction of Cholesterol in Ischemia and Function of the Endothelium) trial. Circulation 99: 3227-3233, 1999.
10. English JL, Jacobs LO, Green G, Andrews TC. Effect of the menstrual cycle on endothelium-dependent vasodilation of the brachial artery in normal young women. Am J Cardiol 82: 256-258, 1998.
11. Frank J, George TW, Lodge JK, Rodriguez-Mateos AM, Spencer JPE, Minihane AM, Rimbach G. Daily consumption of an aqueous green tea extract supplement does not impair liver function or alter cardiovascular disease risk biomarkers in healthy men. J Nutr 139: 58-62, 2009.
12. Freedman RR, Girgis R. Effects of menstrual cycle and race on peripheral vascular alpha-adrenergic responsiveness. Hypertension 35: 795-799, 2000.
13. Ganz P. Vasomotor and vascular effects of hormone replacement therapy. Am J Cardiol 90(1 Suppl. 1): F11-F16, 2002.
14. George TW, Niwat C, Waroonphan S, Gordon MH, Lovegrove JA. Effects of chronic and acute consumption of fruit- and vegetable-puree-based drinks on vasodilation, risk factors for CVD and the response as a result of the eNOS G298T polymorphism. Proc Nutr Soc 68: 148-161, 2009.
15. Hansell J, Henareh L, Agewall S, Norman M. Non-invasive assessment of endothelial function-relation between vasodilatory responses in skin microcirculation and brachial artery. Clin Physiol Funct Imaging 24: 317-322, 2004.
16. Hashimoto M, Akishita M, Eto M, Ishikawa M, Kozaki K, Toba K, Sagara Y, Taketani Y, Orimo H, Ouchi Y. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation 92: 3431-3435, 1995.
17. Higashi Y, Nakagawa K, Kimura M, Noma K, Hara K, Sasaki S, Goto C, Oshima T, Chayama K, Yoshizumi M. Circadian variation of blood pressure and endothelial function in patients with essential hypertension: a comparison of dippers and non-dippers. J Am Coll Cardiol 40: 2039-2043, 2002.
18. Hisamoto K, Bender JR. Vascular cell signaling by membrane estrogen receptors. Steroids 70: 382-387, 2005.
19. John S, Jacobi J, Schlaich MP, Delles C, Schmieder RE. Effects of oral contraceptives on vascular endothelium in premenopausal women. Am J Obstet Gynecol 183: 28-33, 2000.
20. Kalantaridou SN, Naka KK, Papanikolaou E, Kazakos N, Kravariti M, Calis KA, Paraskevaidis EA, Sideris DA, Tsatsoulis A, Chrousos GP, Michalis LK. Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. J Clin Endocrinol Metab 89: 3907-3913, 2004.
21. Kawano H, Motoyama T, Ohgushi M, Kugiyama K, Ogawa H, Yasue H. Menstrual cyclic variation of myocardial ischemia in premenopausal women with variant angina. Ann Intern Med 135: 977-981, 2001.
22. Kelly RP, Millasseau SC, Ritter JM, Chowienczyk PJ. Vasoactive drugs influence aortic augmentation index independently of pulse-wave velocity in healthy men. Hypertension 37: 1429-1433, 2001.
23. Koh KK, Quon MJ, Lee SJ, Han SH, Ahn JY, Kim J-a, Chung W-J, Lee Y, Shin EK. Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension. Diabetes Care 30: 1605-1607, 2007.
24. Kublickiene K, Fu X-D, Svedas E, Landgren B-M, Genazzani AR, Simoncini T. Effects in postmenopausal women of estradiol and medroxyprogesterone alone and combined on resistance artery function and endothelial morphology and movement. J Clin Endocrinol Metab 93: 1874-1883, 2008.
25. Laurent S, Cockcroft J, Van Bortel L, Boutouyrie P, Giannattasio C, Hayoz D et al. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 27: 2588-2605, 2006.
26. Lizarelli P, Martins W, Vieira C, Soares G, Franceschini S, Ferriani R, Patta MC. Both a combined oral contraceptive and depot medroxyprogesterone acetate impair endothelial function in young women. Contraception 79: 35-40, 2009.
27. MacRitchie AN, Jun SS, Chen Z, German Z, Yuhanna IS, Sherman TS, Shaul PW. Estrogen upregulates endothelial nitric oxide synthase gene expression in fetal pulmonary artery endothelium. Circ Res 81: 355-362, 1997.
28. Marc PM. High-dose folic acid supplementation effects on endothelial function and blood pressure in hypertensive patients: a meta-analysis of randomized controlled clinical trials. Journal of Chiropractic Medicine 8: 15-24, 2009.
29. Meendering JR, Torgrimson BN, Miller NP, Kaplan PF, Minson CT. Estrogen, medroxyprogesterone acetate, endothelial function, and biomarkers of cardiovascular risk in young women. Am J Physiol Heart Circ Physiol 294: H1630-H1637, 2008.
30. Meendering JR, Torgrimson BN, Miller NP, Kaplan PF, Minson CT. Ethinyl estradiol-to-desogestrel ratio impacts endothelial function in young women. Contraception 79: 41-49, 2009.
31. Meendering JR, Torgrimson BN, Miller NP, Kaplan PF, Minson CT. A combined oral contraceptive containing 30mcg ethinyl estradiol and 3.0mg drospirenone does not impair endothelium-dependent vasodilation. Contraception 82: 366-372, 2010.
32. Mendelsohn ME. Nongenomic, ER-mediated activation of endothelial nitric oxide synthase: how does it work? What does it mean? Circ Res 87: 956-960, 2000.
33. Millasseau SC, Kelly RP, Ritter JM, Chowienczyk PJ. Determination of age-related increases in large artery stiffness by digital pulse contour analysis. Clin Sci 103: 371-377, 2002.
34. Morris SJ, Shore AC. Skin blood flow responses to the iontophoresis of acetylcholine and sodium nitroprusside in man: possible mechanisms. J Physiol 496(Pt 2): 531-542, 1996.
35. Oesterheld JR, Cozza K, Sandson NB. Oral contraceptives. Psychosomatics 49: 168-175, 2008.
36. Palloshi A, Fragasso G, Piatti P, Monti LD, Setola E, Valsecchi G, Galluccio E, Chierchia SL, Morgonato A. Effect of oral-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol 93: 933-935, 2004.
37. Papaioannou TG, Stamatelopoulos KS, Georgiopoulos G, Vlachopoulos C, Georgiou S, Lykka M, Lambrinoudaki I, Papamichael CM, Stefanadis CI. Arterial wave reflections during the menstrual cycle of healthy women: a reproducibility study. Hypertension 54: 1021-1027, 2009.
38. Rosendaal FR, Helmerhorst FM, Vandenbroucke JP. Female hormones and thrombosis. Arterioscler Thromb Vasc Biol 22: 201-210, 2002.
39. Rossi M, Di Maria C, Erba P, Galetta F, Carpi A, Santoro G. Study of skin vasomotion during phollicular and luteal phase in young healthy women. Clin Hemorheol Microcirc 42: 107-115, 2009.
40. Simoncini T, Fu XD, Caruso A, Garibaldi S, Baldacci C, Giretti MS, Mannella P, Flamini MI, Sanchez AM, Genazzani AR. Drospirenone increases endothelial nitric oxide synthesis via a combined action on progesterone and mineralocorticoid receptors. Hum Reprod 22: 2325-2334, 2007.
41. Torgrimson BN, Meendering JR, Kaplan PF, Minson CT. Endothelial function across an oral contraceptive cycle in women using levonorgestrel and ethinyl estradiol. Am J Physiol Heart Circ Physiol 292: H2874-H2880, 2007.
42. Torgrimson BN, Meendering JR, Miller NP, Kaplan PF, Minson CT. Endothelial function, endothelin-1, and fibrinogen in young women using the vaginal contraceptive ring. Fertil Steril 92: 441-447, 2009.
43. Vandenbroucke JP, Rosing J, Bloemenkamp KWM, Middeldorp S, Helmerhorst FM, Bouma BN, Rosendaal FR. Oral contraceptives and the risk of venous thrombosis. N Engl J Med 344: 1527-1535, 2001.
44. Virdis A, Pinto S, Versari D, Salvetti G, Bernini G, Fruzzetti F, Genazzin AR, Taddei S, Salvetti A. Effect of oral contraceptives on endothelial function in the peripheral microcirculation of healthy women. J Hypertens 21: 2275-2280, 2003.
45. Wilkinson I, Cockcroft J, Webb D. Pulse wave analysis and arterial stiffness. J Cardiovasc Pharmacol 32(Suppl. 3): S33-S37, 1998.
46. Williams MRI, Westerman RA, Kingwell BA, Paige J, Blombery PA, Sudhir K, Komesaroff PA. Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab 86: 5389-5395, 2001.
47. Witte DR, Westerink J, de Koning EJ, van der Graaf Y, Grobbee DE, Bots ML. Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations? J Am Coll Cardiol 45: 1987-1993, 2005.
48. Zerr-Fouineau M, Jourdain M, Boesch C, Hecker M, Bronner C, Schini-Kerth VB. Certain progestins prevent the enhancing effect of 17 beta-estradiol on NO-mediated inhibition of platelet aggregation by endothelial cells. Arterioscler Thromb Vasc Biol 29: 586-593, 2009.