The presence of IGHG1 in human pancreatic carcinomas is associated with immune evasion mechanisms

Pancreas

Volumn 40, Issue 5, 2011, Pages 753-761

  Li, Xiaoyan ^a   Ni, Runzhou ^a   Chen, Jianhua ^a   Liu, Zhaoxiu ^a   Xiao, Mingbing ^a   Jiang, Feng ^a   Lu, Cuihua ^a  

^a NANTONG UNIVERSITY   (China)

Author keywords

ADCC; comparative proteomic analysis; IGHG1; immune escape; NK cells; pancreatic cancer

Indexed keywords

IMMUNOGLOBULIN GAMMA 1 CHAIN C REGION; IMMUNOGLOBULIN HEAVY CHAIN; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY DEPENDENT CELLULAR CYTOTOXICITY; ARTICLE; CANCER GROWTH; CANCER TISSUE; CARCINOGENESIS; CELL ASSAY; CONTROLLED STUDY; DOWN REGULATION; FEMALE; FUNCTIONAL PROTEOMICS; HUMAN; HUMAN TISSUE; IMMUNE EVASION; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; LYMPHOCYTOTOXICITY; MOUSE; NATURAL KILLER CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PANCREAS CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANIMALS; ANTIBODY-DEPENDENT CELL CYTOTOXICITY; BASE SEQUENCE; CARRIER PROTEINS; CELL LINE, TUMOR; CELL PROLIFERATION; DNA PRIMERS; FEMALE; HUMANS; IMMUNOGLOBULIN GAMMA-CHAINS; KILLER CELLS, NATURAL; MICE; MICE, INBRED C57BL; NEOPLASM TRANSPLANTATION; PANCREATIC NEOPLASMS; RECOMBINANT FUSION PROTEINS; TRANSPLANTATION, HETEROLOGOUS; TUMOR ESCAPE; TUMOR MARKERS, BIOLOGICAL;

EID: 79959831598     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e318213d51b     Document Type: Article

References (29)

1. Postier RG. Past, present, and future of pancreatic surgery. Am J Surg. 2001;182:547-551. (Pubitemid 34142670)
2. Brammer R, Buckels J, Bramhall S. Advances in non-operative therapy in pancreatic cancer. Int J Clin Pract. 2000;54:373-381.
3. Sitek B, Sipos B, Alkatout I, et al. Analysis of the pancreatic tumor progression by a quantitative proteomic approach and immunhistochemical validation. J Proteome Res. 2009;8:1647-1656.
4. Xiao J, Lee WN, Zhao Y, et al. Profiling pancreatic cancer-secreted proteome using 15N amino acids and serum-free media. Pancreas. 2010;39:17-23.
5. Deisenhofer J. Crystallographic refinement and atomic models of a human Fc fragment and its complex with fragment B of protein A from Staphylococcus aureus at 2.9- and 2.8-Å resolution. Biochemistry. 1981;20:2361-2370. (Pubitemid 11089772)
6. Schaedel O, Reiter Y. Antibodies and their fragments as anti-cancer agents. Curr Pharm. 2006;12:363-378.
7. Iannello A, Ahmad A. Role of antibody-dependent cell-mediated cytotoxicity in the efficacy of therapeutic anti-cancer monoclonal antibodies. Cancer Metastasis Rev. 2005;24:487-499. (Pubitemid 43096997)
8. Chen Z, Gu J. Immunoglobulin G expression in carcinomas and cancer cell lines. FASEB J. 2007;21:2931-2938. (Pubitemid 47372759)
9. Kimoto Y. Expression of heavy-chain constant region of immunoglobulin and T-cell receptor gene transcripts in human non-hematopoietic tumor cell lines. Genes Chromosomes Cancer. 1998;22:83-86. (Pubitemid 28217811)
10. Zhu X, Li C, Sun X, et al. Immunoglobulin mRNA and protein expression in human oral epithelial tumor cells. Appl Immunohistochem Mol Morphol. 2008;16:232-238. (Pubitemid 351589554)
11. Okabe H, Satoh S, Kato T, et al. Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: Identification of genes involved in viral carcinogenesis and tumor progression. Cancer Res. 2001;61:2129-2137. (Pubitemid 32692038)
12. Li J, Tan C, Xiang Q, et al. Proteomic detection of changes in protein synthesis induced by NGX6 transfected in human nasopharyngeal carcinoma cells. J Protein Chem. 2001;20:265-271.
13. Chen Z, Qiu X, Gu J. Immunoglobulin expression in non-lymphoid lineage and neoplastic cells. Am J Pathol. 2009;174:1139-1148.
14. Hu D, Zheng H, Liu H, et al. Immunoglobulin expression and its biological significance in cancer cells. Cell Mol Immunol. 2008;5:319-324.
15. Qiu X, Zhu X, Zhang L, et al. Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells. Cancer Res. 2003;63:6488-6495. (Pubitemid 37255201)
16. Deng YQ, Zheng J, Li GH, et al. Immunoglobulin expression in colon cancer cell line HT-29 and its biological activities. Zhonghua Zhong Liu Za Zhi. 2006;28:88-91.
17. Zheng H, Li M, Liu H, et al. Immunoglobulin alpha heavy chain derived from human epithelial cancer cells promotes the access of S phase and growth of cancer cells. Cell Biol Int. 2007;31:82-87. (Pubitemid 46138048)
18. Nechansky A, Schuster M, Jost W, et al. Compensation of endogenous IgG mediated inhibition of antibody-dependent cellular cytotoxicity by glyco-engineering of therapeutic antibodies. Mol Immunol. 2007;44:1815-1817.
19. Preithner S, Elm S, Lippold S, et al. High concentrations of therapeutic IgG1 antibodies are needed to compensate for inhibition of antibody-dependent cellular cytotoxicity by excess endogenous immunoglobulin G. Mol Immunol. 2006;43:1183-1193. (Pubitemid 43063171)
20. Koble C, Kyewski B. The thymic medulla: A unique microenvironment for intercellular self-antigen transfer. J Exp Med. 2009;206:1505-1513.
21. Laronne-Bar-On A, Zipori D, Haran-Ghera N. Increased regulatory versus effector T cell development is associated with thymus atrophy in mouse models of multiple myeloma. J Immunol. 2008;181:3714-3724.
22. Chung JW, Yoon SR, Choi I. The regulation of NK cell function and development. Front Biosci. 2008;13:6432-6442.
23. Zusman I, Kossoy G, Ben-Hur H. T cell kinetics and apoptosis in immune organs and mammary tumors of rats treated with cyclophosphamide and soluble tumor-associated antigens. In Vivo. 2002;16:567-576. (Pubitemid 35460371)
24. Corbett TH, Roberts BJ, Leopold WR, et al. Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice. Cancer Res. 1984;44:717-726. (Pubitemid 14184610)
25. Priebe TS, Atkinson EN, Pan BF, et al. Intrinsic resistance to anticancer agents in the murine pancreatic adenocarcinoma PANC02. Cancer Chemother Pharmacol. 1992;29:485-489.
26. Ziske C, Etzrodt PE, Eliu AS, et al. Increase of in vivo antitumoral activity by CD40L (CD154) gene transfer into pancreatic tumor cellYdendritic cell hybrids. Pancreas. 2009;38:758-765.
27. Heukeshoven J, Dernick R. Simplified method for silver staining of proteins in polyacrylamide gels and the mechanism of silver staining. Electrophoresis. 1985;6:103-112. (Pubitemid 15148654)
28. Yan JX, Wait R, Berkelman T, et al. A modified silver staining protocol for visualization of proteins compatible with matrix-assisted laser desorption/ionization and electrospray ionizationYmass spectrometry. Electrophoresis. 2000;21:3666-3672.
29. Shevchenko A, Tomas H, Havlis J, et al. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc. 2006;1:2856-2860.