Mitochondrial biogenesis fails in secondary biliary cirrhosis in rats leadingto mitochondrial DNA depletion and deletions

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 1, 2011, Pages

  Arduini, Alessandro ^a   Serviddio, Gaetano ^b   Escobar, Javier ^a   Tormos, Ana M ^a   Bellanti, Francesco ^b   Viña, José ^a   Monsalve, María ^c   Sastre, Juan ^a  

^a UNIVERSITY OF VALENCIA   (Spain)

^b UNIVERSITY OF FOGGIA   (Italy)

^c CSIC   (Spain)

Author keywords

Chronic cholestasis; Mitochondrial DNA; PGC 1 ; TFAM

Indexed keywords

ADENYLATE KINASE; CASPASE 3; CELL NUCLEUS DNA; GA BINDING PROTEIN; GA BINDING PROTEIN ALPHA; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN BAX; PROTEIN BCL 2; PYRUVATE DEHYDROGENASE; PYRUVATE DEHYDROGENASE KINASE; SINGLE STRANDED DNA BINDING PROTEIN; SIRTUIN 1; TRANSCRIPTION FACTOR NRF1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BILE DUCT LIGATION; BILIARY CIRRHOSIS; BIOGENESIS; CELL PROLIFERATION; CHOLESTASIS; CHRONIC CHOLESTASIS; CONTROLLED STUDY; COPY NUMBER VARIATION; DISEASE ASSOCIATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENERGY CONSUMPTION; ENZYME ACTIVATION; ENZYME BLOOD LEVEL; GENE DELETION; GENOMIC INSTABILITY; LIVER MITOCHONDRION; MALE; MITOCHONDRIAL BIOGENESIS; MITOCHONDRIAL DNA DELETION; MITOCHONDRIAL DNA DEPLETION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RAT; SECONDARY BILIARY CIRRHOSIS;

ANIMALS; BCL-2-ASSOCIATED X PROTEIN; BILE DUCTS; CASPASE 3; CHOLESTASIS; CHRONIC DISEASE; DNA, MITOCHONDRIAL; GA-BINDING PROTEIN TRANSCRIPTION FACTOR; GENE DELETION; GENES, MITOCHONDRIAL; LIVER CIRRHOSIS, BILIARY; MALE; MITOCHONDRIA, LIVER; NF-E2-RELATED FACTOR 1; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, WISTAR; RNA-BINDING PROTEINS; SIRTUIN 1; TRANSCRIPTION FACTORS;

EID: 79959819158     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00253.2010     Document Type: Article

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