Long-term intracerebroventricular infusion of insulin, but not glucose, modulates body weight and hepatic insulin sensitivity by modifying the hypothalamic insulin signaling pathway in type 2 diabetic rats

Neuroendocrinology

Volumn 89, Issue 4, 2009, Pages 387-399

  Park, Sunmin ^a   Hong, Sang Mee ^a   Ahn, Il Sung ^a  

^a Hoseo University   (South Korea)

Author keywords

Euglycemic hyperinsulinemic clamp; Gluconeogenesis; Hyperglycemic clamp; Hypothalamus; Insulin signaling

Indexed keywords

GLUCOSE; GLYCOGEN; INSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CISTERNA MAGNA; CONTROLLED STUDY; FOOD INTAKE; GLUCONEOGENESIS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPOTHALAMUS; INFUSION RATE; INSULIN SENSITIVITY; LIPID DIET; LIVER; LONG TERM CARE; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; OSMOTIC PUMP; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; GLUCOSE; INJECTIONS, INTRAVENTRICULAR; INSULIN; INSULIN INFUSION SYSTEMS; INSULIN RESISTANCE; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 67650222475     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000197974     Document Type: Article

References (36)

1. DeFronzo RA: Pathogenesis of type 2 diabetes mellitus. Med Clin North Am 2004;88: 787-835.
2. Park S, Park CH, Jang JS: Antecedent intake of traditional Asian-style diets exacerbates pancreatic β-cell function, growth and survival after Western-style diet feeding in weaning male rats. J Nutr Biochem 2006;17: 307-318.
3. Levin BE, Dunn-Meynell AA, Routh VH: Brain glucose sensing and body energy homeostasis: role in obesity and diabetes. Am J Physiol 1999;276:R1223-R1231.
4. Levin BE: Metabolic sensing neurons and the control of energy homeostasis. Physiol Behav 2006;89:486-489.
5. Brief DJ, Davis JD: Reduction of food intake and body weight by chronic Intracerebroventricular insulin infusion. Brain Res Bull 1984;12:571-575.
6. Gerozissis K: Brain insulin and feeding: a bidirectional communication. Eur J Pharmacol 2004;490:59-70.
7. Stockhorst U, de Fries D, Steingrueber HJ, Scherbaum WA: Insulin and the CNS: effects on food intake, memory, and endocrine parameters and the role of intranasal insulin administration in humans. Physiol Behav 2004;83:47-54.
8. Schultz-Klarr S, Wright-Richey J, Dunbar JC: Plasma glucose, insulin and cardiovascular responses after intravenous intracerebroventricular injections of insulin, 2-deoxyglucose and glucose in rats. Diabetes Res Clin Pract 1994;26:81-89.
9. Foster LA, Ames NK, Emery RS: Food intake and serum insulin responses to intraventricular infusions of insulin and IGF-I. Physiol Behav 1991;50:745-749.
10. Prodi E, Obici S: The brain as a molecular target for diabetic therapy. Endocrinology 2006;147:2664-2669.
11. Konner AC, Janoschek R, Plum L, Jordan SD, Rother E, Ma X, Xu C, Enriori P, Hampel B, Barsh GS, Kahn CR, Cowley MA, Ashcroft FM, Bruning JC: Insulin action in AgRP-ex-pressing neurons is required for suppression of hepatic glucose production. Cell Metab 2007;5:438-449.
12. Obici S, Zhang BB, Karkanias G, Rossetti L: Hypothalamic insulin signaling is required for inhibition of glucose production. Nat Med 2002;8:1376-1382.
13. Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L: Decreasing hypothalamicinsulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 2002;5:566-572.
14. Cota D, Proulx K, Seeley RJ: The role of CNS fuel sensing in energy and glucose regulation. Gastroenterology 2007;132:2158-2168.
15. Hosokawa YA, Hosokawa H, Chen C, Leahy JL: Mechanism of impaired glucose-potentiated insulin-secretion in diabetic 90 percent pancreatectomy rats - study using glucagonlike peptide-1 (7-37). J Clin Invest 1996;97: 180-186.
16. Kwon DY, Jang JS, Hong SM, Kim DW, Lee JE, Sung SR, Park HR, Park S: Long-term consumption of fermented soybean-derived Chungkookjang enhances insulinotropic action unlike soybeans in 90% pancreatectomized diabetic rats. Eur J Nutr 2007;46: 44-52.
17. Choi SB, Jang JS, Park S: Estrogen and exercise may enhance (3-cell function and mass via insulin receptor substrate 2 induction in ovariectomized diabetic rats. Endocrinology 2005;146: 4786-4794.
18. Committee of the American Institute of Nutrition: Ad hoc committee on standards for nutritional studies. J Nutr 1997;107:1340-1348.
19. Clark KA, MohanKumar SM, Kasturi BS, MohanKumar PS: Effects of central and systemic administration of leptin on neurotransmitter concentrations in specific areas of the hypothalamus. Am J Physiol 2006; 290:R306-R312.
20. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI: Prevention of fatinduced insulin resistance by salicylate. J Clin Invest 2001;108:437-446.
21. Frontoni S, Choi SB, Banduch D, Rossetti L: In vivo insulin resistance induced by amylin primarily through inhibition of insulinstimulated glycogen synthesis in skeletal muscle. Diabetes 1991;40: 568-573.
22. Hennige AM, Burks DJ, Ozcan U, Kulkarni RN, Ye J, Park S, Schubert M, Fisher TL, Dow MA, Leshan R, Zakaria M, Mossa-Basha M, White MF: Upregulation of insulin receptor substrate-2 in pancreatic β-cells prevents diabetes. J Clin Invest 2003;112:1521-1532.
23. Park S, Jang JS, Jun DW, Hong SM: Exercise enhances insulin and leptin signaling in the cerebral cortex and hypothalamus during dexamethasone-induced stress in diabetic rats. Neuroendocrinology 2005;82:282-293.
24. Okamoto H, Obici S, Accili D, Rossetti L: Restoration of liver insulin signaling in Insr knockout mice fails to normalize hepatic insulin action. J Clin Invest 2005;115:1314-1322.
25. Ikeda H, West DB, Pustek JJ, Figlewicz DP, Greenwood MR, Porte D Jr, Woods SC: Intracerebroventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite 1986;7:381-386.
26. Broberger C: Brain regulation of food intake and appetite: molecules and networks. J Intern Med 2005;258:301-327.
27. Claret M, Smith MA, Batterham RL, Selman C, Choudhury AI, Fryer LG, Clements M, Al-Qassab H, Heffron H, Xu AW, Speakman JR, Barsh GS, Viollet B, Vaulont S, Ashford ML, Carling D, Withers DJ: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 2007;117:2325-2336.
28. Kahn B, Alquier T, Carling D, Hardie D: AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab 2005;1: 15-25.
29. Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Ca rling D, Kahn BB: Leptin sti mulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002;415: 339-343.
30. Carvalheira JB, Torsoni MA, Ueno M, Amaral ME, Araujo EP, Velloso LA, Gontijo JA, Saad MJ: Cross-talk between the insulin and leptin signaling systems in rat hypothalamus. Obes Res 2005;13:48-57.
31. Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW: Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2003;52: 227-231.
32. Mayer J: Glucostatic mechanism of regulation of food intake. N Engl J Med 1953;249: 13 -16.
33. Parton LE, Ye CP, Coppari R, Enriori PJ, Choi B, Zhang CY, Xu C, Vianna CR, Balthasar N, Lee CE, Elmquist JK, Cowley MA, Lowell BB: Glucose sensing by POMC neurons regulates glucose homeostasis and i s i mp a i re d i n obe s it y. Nat u re 2 0 0 7;449:228-232.
34. Cherrington AD: The role of hepatic insulin receptors in the regulation of glucose production. J Clin Invest 2005;115:1136-1139.
35. Dong X, Park S, Lin X, Copps K, Yi X, White MF: Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growth. J Clin Invest 2006;116:101-114.
36. Pocai A, Lam TK, Gutierrez-Juarez R, Obici S, Schwartz GJ, Bryan J, Aguilar-Bryan L, Rossetti L: Hypothalamic K (ATP) channels control hepatic glucose production. Nature 2005;434:1026-1031.