Determination of the scale of segregation of low dose tablets using hyperspectral imaging

International Journal of Pharmaceutics

Volumn 414, Issue 1-2, 2011, Pages 157-160

  Ely, David R ^a   Carvajal, M Teresa ^a,b  

^a PURDUE UNIVERSITY   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

Chemical imaging; Hyperspectroscopy; Low dose; NIR; Scale of segregation

Indexed keywords

LACTOSE; MAGNESIUM STEARATE; TOLMETIN;

ARTICLE; HYPERSPECTROSCOPY; ILLUMINATION; IMAGE ANALYSIS; IMAGING; IMAGING SYSTEM; INFRARED SPECTROSCOPY; LASER; LOW DRUG DOSE; NEAR INFRARED RADIATION HYPERSPECTRAL IMAGING; PRIORITY JOURNAL; TABLET;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DRUG COMPOUNDING; EXCIPIENTS; LACTOSE; SPECTROSCOPY, NEAR-INFRARED; STEARIC ACIDS; TABLETS; TOLMETIN;

EID: 79959757621     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.027     Document Type: Article

References (10)

1. J.M. Amigo, and C. Ravn Direct quantification and distribution assessment of major and minor components in pharmaceutical tablets by NIR-chemical imaging Eur. J. Pharm. Sci. 37 2009 76 82
2. ASTM, 2000. Standard practices for infrared multivariate quantitative analysis: E 1655-00.
3. P.V. Danckwerts The definition and measurement of some characteristics of mixtures Appl. Sci. Res. 3 1952 279 296
4. D. Ely, S. Chamarthy, and M.T. Carvajal An investigation into low dose blend uniformity and segregation determination using NIR spectroscopy Colloids Surf. A Physicochem. Eng. Aspects 288 2006 71 76 (Pubitemid 44233239)
5. B.J. Ennis Measuring Powder Flowability and Its Applications: A Hands-on Design-oriented Workshop 2006 The Inn at Evins Mill Nashville, TN
6. D.S. Hausman, R.T. Cambron, and A. Sakr Application of Raman spectroscopy for on-line monitoring of low dose blend uniformity Int. J. Pharm. 298 2005 80 90 (Pubitemid 40828329)
7. M.C.R. Johnson The effect of particle size upon mixture homogeneity Pharm. Acta Helv. 50 1975 60 63
8. C.K. Lai, and C.C. Cooney Application of a fluorescence sensor for miniscale on-line monitoring of powder mixing kinetics J. Pharm. Sci. 93 2004 60 70 (Pubitemid 38081814)
9. C.K. Lai, D. Holt, J.C. Leung, C.L. Cooney, G.K. Raju, and P. Hansen Real time and noninvasive monitoring of dry powder blend homogeneity AIChE J. 47 2001 2618
10. G. Léonard, F. Bertrand, J. Chaouki, and P.M. Gosselin An experimental investigation of effusivity as an indicator of powder blend uniformity Powder Technol. 181 2008 149 159