Application of a Fluorescence Sensor for Miniscale On-line Monitoring of Powder Mixing Kinetics

Journal of Pharmaceutical Sciences

Volumn 93, Issue 1, 2004, Pages 60-70

  Lai, Chee Kong ^a   Cooney, Charles C ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

Author keywords

Blend homogeneity; Blend stability; Light induced fluorescence; Noninvasive; On line; Pharmaceuticals; Powders

Indexed keywords

AMOXICILLIN; EXCIPIENT; LACTOSE; MICROCRYSTALLINE CELLULOSE; TETRAHYDROLIPSTATIN; TRIAMTERENE;

ANALYTIC METHOD; ARTICLE; BIOLOGICAL MONITORING; BIOSENSOR; DRUG FORMULATION; DRUG MONITORING; DRUG STABILITY; FLUORESCENCE; MEDICAL TECHNOLOGY; SAMPLING; ULTRAVIOLET SPECTROPHOTOMETRY;

EID: 0345863530     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10478     Document Type: Article

References (24)

1. Poole KR, Taylor RF, Wall GP. 1964. Mixing powders to fine-scale homogeneity: studies of batch mixing. Trans Inst Chem Eng 42:T305-T315.
2. Harwood CF, Ripley T. 1977. Errors associated with the thief probe for bulk powder sampling. J Powder Bulk Solids Tech 1:20-29.
3. Carstensen JT, Rhodes CT. 1993. Sampling in blending validation. Drug Dev Ind Pharm 19: 2699-2708.
4. Garcia T, Elsheimer B, Tarczynski F. 1995. Examination of components of variance for a production scale, low dose powder blend and resulting tablets. Drug Dev Ind Pharm 21:2035-2045.
5. Berman J, Schoeneman A, Shelton JT. 1996. Unit dose sampling - A tale of two thieves. Drug Dev Ind Pharm 22:1121-1132.
6. Muzzio FJ, Robinson P, Wightman C, Brone D. 1977. Sampling practices in powder blending. Int J Pharm 155:153-178.
7. Carley-Macauly KW, Donald MB. 1962. The mixing of solids in tumbling mixers - I. Chem Eng Sci 17:493-506.
8. Harwood CF, Walanski KA. 1973. Monitoring the mixing of powders. ACS Div Org Coatings Plastic Chem 33:508-515.
9. Orr NA, Shotton E. 1973. The mixing of cohesive powders. Chem Eng January: 12-19.
10. Schofield C. 1976. The definition and assessment of mixture quality in mixtures of particulate solids. Powder Technol 15:169-180.
11. Thiel WJ, Stephenson PL. 1982. Assessing the homogeneity of and ordered mixture. Powder Technol 31:45-50.
12. Carstensen JT, Dali MV. 1996. Blending validation and content uniformity of low-content noncohesive powder blends. Drug Dev Ind Pharm 22:285-290.
13. Lantz RL Jr, Schwartz JB. 1990. Pharmaceutical dosage forms - Tablets, vol. 2. In: Lieberman HA, Lachman L, Schwartz JB, editors. 2nd ed. New York: Marcel Dekker. pp 27-32.
14. Lantz RL Jr, Schwartz JB. 1990. Pharmaceutical dosage forms - Tablets, vol. 2. In: Lieberman HA, Lachman L, Schwartz JB, editors. 2nd ed. New York: Marcel Dekker. pp 158-162.
15. Allen T. 1990. Particle size measurement, 4th ed. London: Chapman and Hall.
16. Timmermans JH. 2001. A report of the PQRI workshop on blend uniformity. Pharm Tech 25:76-84.
17. Wechsler J. 2002. Modernizing pharmaceutical manufacturing. Pharm Tech 26:16-24.
18. Lai CK, Holt D, Leung JC, Raju GK, Hansen P, Cooney CL. 2001. Real time and non-invasive monitoring of dry powder blend homogeneity. AIChE J 47:2618-2622.
19. Allen T. 1981. Particle size measurement, 3rd ed. London: Chapman and Hall, p 5.
20. Brittain HG. 2002. Particle size distribution II: The problem of sampling powdered solids. Pharm Tech 26:67-73.
21. Hogg R, Cahn DS, Healy TW, Fuerstenau DW. 1966. Diffusional mixing in an ideal system. Chem Eng Sci 21:1025-1038.
22. Miyanami K. 1997. Mixing. In: Gotoh K, Masuda H, Higashitani K, editors. Powder technology handbook. New York: Marcel Dekker, pp 609-626.
23. Muzzio FJ, Moakher M, Shinbrot T. 2000. Experimentally validated computations of flow, mixing and segregation of non-cohesive grains in 3D tumbling blenders. Powder Technol 109:58-71.
24. Bridgwater J. 1976. Fundamental powder mixing mechanisms. Powder Technol 15:215-236.