Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects

Annals of Oncology

Volumn 22, Issue 7, 2011, Pages 1478-1486

  Raijmakers, N J H ^a   van Zuylen, L ^a   Costantini, M ^b   Caraceni, A ^c   Clark, J ^d   Lundquist, G ^e   Voltz, R ^f   Ellershaw, J E ^g   van der Heide, A ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b National Cancer Research Institute   (United States)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d Education and Research Unit   (New Zealand)

^e Department of Palliative Home Care ^*  (Sweden)

^f UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^g UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Artificial hydration; Artificial nutrition; Dying phase; End of life; Palliative care; Terminal care

Indexed keywords

ARTIFICIAL FEEDING; ARTIFICIAL HYDRATION; ASCITES; CANCER MORTALITY; CANCER PALLIATIVE THERAPY; CANCER PATIENT; CANCER SURVIVAL; CHRONIC DISEASE; DEHYDRATION; DELIRIUM; EVIDENCE BASED PRACTICE; FLUID THERAPY; HUMAN; HYPERVOLEMIA; NAUSEA; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SYSTEMATIC REVIEW; TERMINAL CARE; TERMINALLY ILL PATIENT; THIRST; TREATMENT RESPONSE;

EID: 79959739648     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdq620     Document Type: Review

References (71)

1. Cinocco D. The difficulties of swallowing at the end of life. J Palliat Med 2007; 10(2): 506-508.
2. Tsai JS, Wu CH, Chiu TY et al. Symptom patterns of advanced cancer patients in a palliative care unit. Palliat Med 2006; 20(6): 617-622.
3. Chiu TY, Hu WY, Chuang RB et al. Nutrition and hydration for terminal cancer patients in Taiwan. Support Care Cancer 2002; 10(8): 630-636.
4. Komurcu S, Nelson KA, Walsh D et al. Gastrointestinal symptoms among inpatients with advanced cancer. Am J Hosp Palliat Care 2002; 19(5): 351-355.
5. Conill C, Verger E, Henriquez I et al. Symptom prevalence in the last week of life. J Pain Symptom Manage 1997; 14(6): 328-331.
6. Coyle N, Adelhardt J, Foley KM et al. Character of terminal illness in the advanced cancer patient: pain and other symptoms during the last four weeks of life. J Pain Symptom anage 1990; 5(2): 83-93.
7. Duerksen DR, Ting E, Thomson P et al. Is there a role for TPN in terminally ill patients with bowel obstruction? Nutrition 2004; 20(9): 760-763.
8. Pothuri B, Montemarano M, Gerardi M et al. Percutaneous endoscopic gastrostomy tube placement in patients with malignant bowel obstruction due to ovarian carcinoma. ynecol Oncol 2005; 96(2): 330-334.
9. Ellershaw JE, Sutcliffe JM, Saunders CM. Dehydration and the dying patient. J Pain Symptom Manage 1995; 10(3): 192-197.
10. Capuano G, Gentile PC, Bianciardi F et al. Prevalence and influence of malnutrition on quality of life and performance status in patients with locally advanced head and neck cancer efore treatment. Support Care Cancer 2010; 18: 433-437.
11. Tsoussis S, Ikonomidou F, Vourliotaki I et al. Clinical burden of terminal phase in cancer patients. J BUON 2007; 12(3): 383-388.
12. McCann RM, Hall WJ, Groth-Juncker A. Comfort care for terminally ill patients. The appropriate use of nutrition and hydration. JAMA 1994; 272(16): 1263-1266.
13. Bozzetti F, Arends J, Lundholm K et al. ESPEN guidelines on parenteral nutrition: non-surgical oncology. Clin Nutr 2009; 28: 445-454.
14. Mazaki T, Ebisawa K. Enteral versus parenteral nutrition after gastrointestinal surgery: a systematic review and meta-analysis of randomized controlled trials in the English literature. J Gastrointest Surg 2008; 12(4): 739-755.
15. Wu MH, Lin MT, Chen WJ. Effect of perioperative parenteral nutritional support for gastric cancer patients undergoing gastrectomy. Hepatogastroenterology 2008; 55(82-83): 99-802.
16. Buiting HM, van Delden JJ, Rietjens JA et al. Forgoing artificial nutrition or hydration in patients nearing death in six European countries. J Pain Symptom Manage 2007; 34(3): 05-314.
17. Fan BG. Parenteral nutrition prolongs the survival of patients associated with malignant gastrointestinal obstruction. JPEN J Parenter Enteral Nutr 2007; 31(6): 508-510.
18. Shang E, Weiss C, Post S et al. The influence of early supplementation of parenteral nutrition on quality of life and body composition in patients with advanced cancer. JPEN J arenter Enteral Nutr 2006; 30(3): 222-230.
19. Bozzetti F, Cozzaglio L, Biganzoli E et al. Quality of life and length of survival in advanced cancer patients on home parenteral nutrition. Clin Nutr 2002; 21(4): 281-288.
20. Rudberg MA, Egleston BL, Grant MD et al. Effectiveness of feeding tubes in nursing home residents with swallowing disorders. JPEN J Parenter Enteral Nutr 2000; 24(2): 97-02.
21. Arends J, Bodoky G, Bozzetti F et al. ESPEN guidelines on enteral nutrition: nonsurgical oncology. Clin Nutr 2006; 25(2): 245-259.
22. Good P, Cavenagh J, Mather M et al. Medically assisted hydration for palliative care patients. Cochrane Database Syst Rev 2008; (2): CD006273.
23. Good P, Cavenagh J, Mather M et al. Medically assisted nutrition for palliative care in adult patients. Cochrane Database Syst Rev 2008; (4): CD006274.
24. Teunissen SC, Wesker W, Kruitwagen C et al. Symptom prevalence in patients with incurable cancer: a systematic review. J Pain Symptom Manage 2007; 34(1): 94-104.
25. Kamei T, Shimanouchi S, Nakayama Y. Preliminary study of change in the terminal care needs of cancer patients at home. Int Med J 1999; 6(2): 101-107.
26. Sato K, Miyashita M, Morita T et al. Quality of end-of-life treatment for cancer patients in general wards and the palliative care unit at a regional cancer center in Japan: a etrospective chart review. Support Care Cancer 2008; 16(2): 113-122.
27. Oh DY, Kim JH, Lee SH et al. Artificial nutrition and hydration in terminal cancer patients: the real and the ideal. Support Care Cancer 2007; 15(6): 631-636.
28. Masuda Y, Noguchi H, Kuzuya M et al. Comparison of medical treatments for the dying in a hospice and a geriatric hospital in Japan. J Palliat Med 2006; 9(1): 152-160.
29. Morita T, Hyodo I, Yoshimi T et al. Artificial hydration therapy, laboratory findings, and fluid balance in terminally ill patients with abdominal malignancies. J Pain Symptom anage 2006; 31(2): 130-139.
30. Lanuke K, Fainsinger RL, DeMoissac D. Hydration management at the end of life. J Palliat Med 2004; 7(2): 257-263.
31. Goncalves JF, Alvarenga M, Silva A. The last forty-eight hours of life in a Portuguese palliative care unit: does it differ from elsewhere? J Palliat Med 2003; 6(6): 895-900.
32. Morita T, Tei Y, Inoue S. Agitated terminal delirium and association with partial opioid substitution and hydration. J Palliat Med 2003; 6(4): 557-563.
33. Groenewoud JH, van der Heide A, Kester JG et al. A nationwide study of decisions to forego life-prolonging treatment in Dutch medical practice. Arch Intern Med 2000; 160(3): 57-363.
34. Bosshard G, Nilstun T, Bilsen J et al. Forgoing treatment at the end of life in 6 European countries. Arch Intern Med 2005; 165(4): 401-407.
35. Fins JJ, Miller FG, Acres CA et al. End-of-life decision-making in the hospital: current practice and future prospects. J Pain Symptom Manage 1999; 17(1): 6-15.
36. Bruera E, Pruvost M, Schoeller T et al. Proctoclysis for hydration of terminally ill cancer patients. J Pain Symptom Manage 1998; 15(4): 216-219.
37. Cerchietti L, Navigante A, Sauri A et al. Hypodermoclysis for control of dehydration in terminal-stage cancer. Int J Palliat Nurs 2000; 6(8): 370-374.
38. Morita T, Hyodo I, Yoshimi T et al. Association between hydration volume and symptoms in terminally ill cancer patients with abdominal malignancies. Ann Oncol 2005; 16(4): 40-647.
39. Ellershaw J. Care of the dying: what a difference an LCP makes! Palliat Med 2007; 21(5): 365-368.
40. Ellershaw JE, Murphy D. The Liverpool Care Pathway (LCP) influencing the UK national agenda on care of the dying. Int J Palliat Nurs 2005; 11(3): 132-134.
41. Badger F, Thomas K, Clifford C. Raising standards for elderly people dying in care homes. Eur J Palliat Care 2007; 14(6): 4.
42. Veerbeek L, van Zuylen L, Swart SJ et al. The effect of the Liverpool Care Pathway for the dying: a multi-centre study. Palliat Med 2008; 22(2): 145-151.
43. Badger F, Clifford C, Hewison A et al. An evaluation of the implementation of a programme to improve end-of-life care in nursing homes. Palliat Med 2009; 23(6): 502-511.
44. Chan R, Webster J. End-of-life care pathways for improving outcomes in caring for the dying. Cochrane Database Syst Rev 2010; (1): CD008006.
45. Hickman SE, Tolle SW, Brummel-Smith K et al. Use of the Physician Orders for Life-Sustaining Treatment program in Oregon nursing facilities: beyond resuscitation status. J Am eriatr Soc 2004; 52(9): 1424-1429.
46. Konishi E, Davis AJ, Aiba T. The ethics of withdrawing artificial food and fluid from terminally ill patients: an end-of-life dilemma for Japanese nurses and families. Nurs Ethics 2002; 9(1): 7-19.
47. Chiu TY, Hu WY, Chuang RB et al. Terminal cancer patients' wishes and influencing factors toward the provision of artificial nutrition and hydration in Taiwan. J Pain Symptom anage 2004; 27(3): 206-214.
48. Morita T, Miyashita M, Shibagaki M et al. Knowledge and beliefs about end-oflife care and the effects of specialized palliative care: a population-based survey in Japan. J Pain ymptom Manage 2006; 31(4): 306-316.
49. Morita T, Tsunoda J, Inoue S et al. Perceptions and decision-making on rehydration of terminally ill cancer patients and family members. Am J Hosp Palliat Care 1999; 16(3): 09-516.
50. Mercadante S, Ferrera P, Girelli D et al. Patients' and relatives' perceptions about intravenous and subcutaneous hydration. J Pain Symptom Manage 2005; 30(4): 354-358.
51. Craig GM. On withholding artificial hydration and nutrition from terminally ill sedated patients. The debate continues. J Med Ethics 1996; 22(3): 147-153.
52. Geppert CM, Andrews MR, Druyan ME. Ethical issues in artificial nutrition and hydration: a review. JPEN J Parenter Enteral Nutr 2010; 34(1): 79-88.
53. Kwak J, Haley WE. Current research findings on end-of-life decision making among racially or ethnically diverse groups. Gerontologist 2005; 45(5): 634-641.
54. Pang MC, Volicer L, Chung PM et al. Comparing the ethical challenges of forgoing tube feeding in American and Hong Kong patients with advanced dementia. J Nutr Health ging 2007; 11(6): 495-501.
55. Ko E, Lee J. End-of-life communication: ethnic differences between Korean American and non-Hispanic White older adults. J Aging Health 2009; 21(7): 967-984.
56. Perkins HS, Cortez JD, Hazuda HP. Cultural beliefs about a patient's right time to die: an exploratory study. J Gen Intern Med 2009; 24(11): 1240-1247.
57. Blackhall LJ, Murphy ST, Frank G et al. Ethnicity and attitudes toward patient autonomy. JAMA 1995; 274(10): 820-825.
58. Tsai LY, Lee MY, Lai YL. Practical effects of educating nurses on the Natural Death Act. Support Care Cancer 2005; 13(4): 6.
59. Bruera E, Sala R, Rico MA et al. Effects of parenteral hydration in terminally ill cancer patients: a preliminary study. J Clin Oncol 2005; 23(10): 2366-2371.
60. Steinhauser KE, Clipp EC, Bosworth HB et al. Measuring quality of life at the end of life: validation of the QUAL-E. Palliat Support Care 2004; 2(1): 3-14.
61. Steinhauser KE, Bosworth HB, Clipp EC et al. Initial assessment of a new instrument to measure quality of life at the end of life. J Palliat Med 2002; 5(6): 829-841.
62. Diehr P, Lafferty WE, Patrick DL et al. Quality of life at the end of life. Health Qual Life Outcomes 2007; 5: 51.
63. Groenvold M, Petersen MA, Aaronson NK et al. The development of the EORTC QLQ-C15-PAL: a shortened questionnaire for cancer patients in palliative care. Eur J Cancer 006; 42(1): 55-64.
64. Albers G, Echteld MA, de Vet HC et al. Evaluation of quality-of-life measures for use in palliative care: a systematic review. Palliat Med 2010; 24(1): 17-37.
65. Fainsinger RL, MacEachern T, Miller MJ et al. The use of hypodermoclysis for rehydration in terminally ill cancer patients. J Pain Symptom Manage 1994; 9(5): 298-302.
66. Fainsinger RL, Bruera E. When to treat dehydration in a terminally ill patient? Support Care Cancer 1997; 5(3): 205-211.
67. Rees E, Hardy J. Novel consent process for research in dying patients unable to give consent. BMJ (Clinical Research Ed) 2003; 327(7408): 198.
68. Scales DC, Smith OM, Pinto R et al. Patients' preferences for enrolment into critical-care trials. Intensive Care Med 2009; 35(10): 1703-1712.
69. Jansen TC, Kompanje EJ, Bakker J. Deferred proxy consent in emergency critical care research: ethically valid and practically feasible. Crit Care Med 2009; 37 (1 Suppl): S65-68.
70. Varma S, Jenkins T, Wendler D. How do children and parents make decisions about pediatric clinical research? J Pediatr Hematol Oncol 2008; 30(11): 823-828.
71. Stadhouder A, Oner FC, Wilson KW et al. Surgeon equipoise as an inclusion criterion for the evaluation of nonoperative versus operative treatment of thoracolumbar spinal njuries. Spine J 2008; 8(6): 975-981.