Comparison of virtual high-throughput screening methods for the identification of phosphodiesterase-5 inhibitors

Journal of Chemical Information and Modeling

Volumn 51, Issue 6, 2011, Pages 1353-1363

  Niinivehmas, Sanna P ^a   Virtanen, Salla I ^a   Lehtonen, Jukka V ^b   Postila, Pekka A ^a,c   Pentikäinen, Olli T ^a  

^a UNIVERSITY OF JYVÄSKYLÄ   (Finland)

^b ÅBO AKADEMI UNIVERSITY   (Finland)

^c TAMPERE UNIVERSITY OF TECHNOLOGY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

DISSOCIATION; ELECTROSTATICS; ESTERS; IMAGE ENHANCEMENT; LIGANDS; PROTEINS;

HIGH THROUGHPUT SCREENING; HIGH THROUGHPUT SCREENING METHODS; LIGAND-BINDING SITES; LIGAND-PROTEIN INTERACTION; PHOSPHODIESTERASE 5 INHIBITORS; PHOSPHODIESTERASES; SOLVATION STATE; TARGET PROTEINS;

DRUG PRODUCTS;

LIGAND; PHOSPHODIESTERASE V; PHOSPHODIESTERASE V INHIBITOR;

ARTICLE; CHEMISTRY; COMPARATIVE STUDY; COMPUTER INTERFACE; DRUG SCREENING; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; HIGH THROUGHPUT SCREENING; METABOLISM; METHODOLOGY; MOLECULAR DYNAMICS; STATIC ELECTRICITY;

CATALYTIC DOMAIN; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; LIGANDS; MOLECULAR DYNAMICS SIMULATION; PHOSPHODIESTERASE 5 INHIBITORS; STATIC ELECTRICITY; SUBSTRATE SPECIFICITY; USER-COMPUTER INTERFACE;

EID: 79959737431     PISSN: 15499596     EISSN: 1549960X     Source Type: Journal    
DOI: 10.1021/ci1004527     Document Type: Article

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