Gene expression analysis in radiotherapy patients and C57BL/6 mice as a measure of exposure to ionizing radiation

Radiation Research

Volumn 176, Issue 1, 2011, Pages 49-61

  Filiano, Ashley N ^a   Fathallah Shaykh, Hassan M ^b   Fiveash, John ^c   Gage, Jarrod ^d   Cantor, Alan ^e   Kharbanda, Sandhya ^f   Johnson, Martin R ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c The University of Alabama at Birmingham   (United States)

^d BIRMINGHAM CHILDREN S HOSPITAL   (United Kingdom)

^e University of Alabama at Birmingham   (United States)

^f STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ACTIN ALPHA 2 SMOOTH MUSCLE AORTA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN G1; ENZYME INHIBITOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MIDKINE; PUMA PROTEIN; SERPIN PEPTIDASE INHIBITOR CLADE E MEMBER 1; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BLOOD SAMPLING; CANCER RADIOTHERAPY; CASE REPORT; DOSIMETRY; FEMALE; GENE; GENE EXPRESSION; HUMAN; IONIZING RADIATION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RADIATION EXPOSURE; SENSITIVITY AND SPECIFICITY;

ADOLESCENT; ALGORITHMS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; LINEAR MODELS; MALE; MICE; MICE, INBRED C57BL; PRECURSOR CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; RADIATION INJURIES, EXPERIMENTAL; RADIATION, IONIZING; RADIOMETRY; TIME FACTORS; WHOLE-BODY IRRADIATION; YOUNG ADULT;

MUS;

EID: 79959736851     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2419.1     Document Type: Article

References (51)

1. N. Dainiak, P. Berger and J. Albanese, Relevance and feasibility of multi-parameter assessment for management of mass casualties from a radiological event. Exp. Hematol. 35, 17-23 (2007). (Pubitemid 46427977)
2. I. Turai, K. Veress, B. Gunalp and G. Souchkevitch, Medical response to radiation incidents and radionuclear threats. BMJ 328, 568-572 (2004). (Pubitemid 38316631)
3. J. K. Waselenko, T. J. MacVittie, W. F. Blakely, N. Pesik, A. L. Wiley, W. E. Dickerson, H. Tsu, D. L. Confer, C. N. Coleman and N. Dainiak, Medical management of the acute radiation syndrome: recommendations of the Strategic National Stockpile Radiation Working Group. Ann. Intern. Med. 140, 1037-1051 (2004).
4. E. Hall and A. Giaccia, DNA strand breaks and chromosomal aberrations. In Radiobiology for the Radiologist, 6th ed., pp. 16- .29. Lippincott Williams & Wilkins, Philadelphia, 2006.
5. M. Shrivastav, L. P. De Haro and J. A. Nickoloff, Regulation of DNA double-strand break repair pathway choice. Cell Res. 18, 134-147 (2008).
6. M. A. Bender and P. C. Gooch, Somatic chromosome aberrations induced by human whole-body irradiation: the "Recuplex" criticality accident. Radiat. Res. 29, 568-582 (1966).
7. G. S. Akerman, B. A. Rosenzweig, O. E. Domon, C. A. Tsai, M. E. Bishop, L. J. McGarrity, J. T. Macgregor, F. D. Sistare, J. J. Chen and S. M. Morris, Alterations in gene expression profiles and the DNA-damage response in ionizing radiation-exposed TK6 cells. Environ. Mol. Mutagen. 45, 188-205 (2005).
8. S. A. Amundson, M. Bittner, Y. Chen, J. Trent, P. Meltzer and A. J. Fornace, Jr., Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18, 3666-3672 (1999). (Pubitemid 29322393)
9. S. A. Amundson, M. Bittner and A. J. Fornace, Jr., Functional genomics as a window on radiation stress signaling. Oncogene 22, 5828-5833 (2003). (Pubitemid 37176703)
10. S. A. Amundson, K. T. Do, L. C. Vinikoor, R. A. Lee, C. A. Koch-Paiz, J. Ahn, M. Reimers, Y. Chen, D. A. Scudiero and A. J. Fornace, Jr., Integrating global gene expression and radiation survival parameters across the 60 cell lines of the National Cancer Institute Anticancer Drug Screen. Cancer Res. 68, 415-424 (2008). (Pubitemid 351380067)
11. S. A. Amundson, R. A. Lee, C. A. Koch-Paiz, M. L. Bittner, P. Meltzer, J. M. Trent and A. J. Fornace, Jr., Differential responses of stress genes to low dose-rate gamma irradiation. Mol. Cancer Res. 1, 445-452 (2003). (Pubitemid 36459255)
12. B. N. Ford, D. Wilkinson, E. M. Thorleifson and B. L. Tracy, Gene expression responses in lymphoblastoid cells after radiation exposure. Radiat. Res. 156, 668-671 (2001). (Pubitemid 33027546)
13. K. Y. Jen and V. G. Cheung, Identification of novel p53 target genes in ionizing radiation response. Cancer Res. 65, 7666-7673 (2005). (Pubitemid 41297240)
14. K. Y. Jen and V. G. Cheung, Transcriptional response of lymphoblastoid cells to ionizing radiation. Genome Res. 13, 2092-2100 (2003). (Pubitemid 37161766)
15. C. M. Kang, K. P. Park, J. E. Song, D. I. Jeoung, C. K. Cho, T. H. Kim, S. Bae, S. J. Lee and Y. S. Lee, Possible biomarkers for ionizing radiation exposure in human peripheral blood lymphocytes. Radiat. Res. 159, 312-319 (2003). (Pubitemid 36314945)
16. R. Lin, Y. Sun, C. Li, C. Xie and S. Wang, Identification of differentially expressed genes in human lymphoblastoid cells exposed to irradiation and suppression of radiation-induced apoptosis with antisense oligonucleotides against caspase-4. Oligonucleotides 17, 314-326 (2007). (Pubitemid 47463363)
17. X. H. Long, Z. Q. Zhao, X. P. He, H. P. Wang, Q. Z. Xu, J. An, B. Bai, J. L. Sui and P. K. Zhou, Dose-dependent expression changes of early response genes to ionizing radiation in human lymphoblastoid cells. Int. J. Mol. Med. 19, 607-615 (2007).
18. V. G. Tusher, R. Tibshirani and G. Chu, Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98, 5116-5121 (2001). (Pubitemid 32397092)
19. H. P. Wang, X. H. Long, Z. Z. Sun, O. Rigaud, Q. Z. Xu, Y. C. Huang, J. L. Sui, B. Bai and P. K. Zhou, Identification of differentially transcribed genes in human lymphoblastoid cells irradiated with 0.5 Gy of gamma-ray and the involvement of low dose radiation inducible CHD6 gene in cell proliferation and radiosensitivity. Int. J. Radiat. Biol. 82, 181-190 (2006).
20. O. Zschenker, K. Borgmann, T. Streichert, I. Meier, A. Wrona and E. Dikomey, Lymphoblastoid cell lines differing in p53 status show clear differences in basal gene expression with minor changes after irradiation. Radiother. Oncol. 80, 236-249 (2006). (Pubitemid 44314016)
21. H. K. Dressman, G. G. Muramoto, N. J. Chao, S. Meadows, D. Marshall, G. S. Ginsburg, J. R. Nevins and J. P. Chute, Gene expression signatures that predict radiation exposure in mice and humans. PLoS Med. 4, e106 (2007).
22. G. Gruel, C. Lucchesi, A. Pawlik, V. Frouin, O. Alibert, T. Kortulewski, A. Zarour, B. Jacquelin, X. Gidrol and D. Tronik- Le Roux, Novel microarray-based method for estimating exposure to ionizing radiation. Radiat. Res. 166, 746-756 (2006). (Pubitemid 44706611)
23. S. K. Meadows, H. K. Dressman, P. Daher, H. Himburg, J. L. Russell, P. Doan, N. J. Chao, J. Lucas, J. R. Nevins and J. P. Chute, Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. PLoS One 5, e11535 (2010).
24. S. K. Meadows, H. K. Dressman, G. G. Muramoto, H. Himburg, A. Salter, Z. Wei, G. S. Ginsburg, N. J. Chao, J. R. Nevins and J. P. Chute, Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. PLoS One 3, e1912 (2008).
25. S. A. Amundson, K. T. Do, S. Shahab, M. Bittner, P. Meltzer, J. Trent and A. J. Fornace, Jr., Identification of potential mRNA biomarkers in peripheral blood lymphocytes for human exposure to ionizing radiation. Radiat. Res. 154, 342-346 (2000).
26. E. Kis, T. Szatmari, M. Keszei, R. Farkas, O. Esik, K. Lumniczky, A. Falus and G. Safrany, Microarray analysis of radiation response genes in primary human fibroblasts. Int. J. Radiat. Oncol. Biol. Phys. 66, 1506-1514 (2006).
27. M. Mori, M. A. Benotmane, I. Tirone, E. L. Hooghe-Peters and C. Desaintes, Transcriptional response to ionizing radiation in lymphocyte subsets. Cell Mol. Life Sci. 62, 1489-1501 (2005). (Pubitemid 40922951)
28. W. Y. Park, C. I. Hwang, C. N. Im, M. J. Kang, J. H. Woo, J. H. Kim, Y. S. Kim, J. H. Kim, H. Kim and J. S. Seo, Identification of radiation-specific responses from gene expression profile. Oncogene 21, 8521-8528 (2002). (Pubitemid 36054894)
29. S. Paul and S. A. Amundson, Development of gene expression signatures for practical radiation biodosimetry. Int. J. Radiat. Oncol. Biol. Phys. 71, 1236-1244 (2008).
30. A. Turtoi, I. Brown, D. Oskamp and F. H. Schneeweiss, Early gene expression in human lymphocytes after gamma-irradiationa genetic pattern with potential for biodosimetry. Int. J. Radiat. Biol. 84, 375-387 (2008). (Pubitemid 351878841)
31. S. A. Amundson, M. B. Grace, C. B. McLeland, M. W. Epperly, A. Yeager, Q. Zhan, J. S. Greenberger and A. J. Fornace, Jr., Human in vivo radiation-induced biomarkers: gene expression changes in radiotherapy patients. Cancer Res. 64, 6368-6371 (2004). (Pubitemid 39297886)
32. M. B. Grace, C. B. McLeland and W. F. Blakely, Real-time quantitative RT-PCR assay of GADD45 gene expression changes as a biomarker for radiation biodosimetry. Int. J. Radiat. Biol. 78, 1011-1021 (2002). (Pubitemid 35333034)
33. M. B. Grace, C. A. Salter, J. R. Bullard, P. G. Prasanna, G. L. Manglapus and W. F. Blakely, Gene-expression biomarkers for application to high-throughput radiation biodosimetry. In NATO Human Factors and Medicine Panel Research Task Group 099 "Radiation Bioeffects and Countermeasures," pp. 12- 1-12-15. Armed Forces Radiobiology Research Institute, Bethesda, MD, 2005.
34. K. Bishay, K. Ory, M. F. Olivier, J. Lebeau, C. Levalois and S. Chevillard, DNA damage-related RNA expression to assess individual sensitivity to ionizing radiation. Carcinogenesis 22, 1179-1183 (2001). (Pubitemid 32737332)
35. A. Steg, S. M. Vickers, M. Eloubeidi, W. Wang, I. A. Eltoum, W. E. Grizzle, M. W. Saif, A. F. Lobuglio, A. R. Frost and M. R. Johnson, Hedgehog pathway expression in heterogeneous pancreatic adenocarcinoma: implications for the molecular analysis of clinically available biopsies. Diagn. Mol. Pathol. 16, 229-237 (2007). (Pubitemid 350196981)
36. A. Steg, W. Wang, C. Blanquicett, J. M. Grunda, I. A. Eltoum, K. Wang, D. J. Buchsbaum, S. M. Vickers, S. Russo and M. R. Johnson, Multiple gene expression analyses in paraffinembedded tissues by TaqMan low-density array: Application to hedgehog and Wnt pathway analysis in ovarian endometrioid adenocarcinoma. J. Mol. Diagn. 8, 76-83 (2006). (Pubitemid 43257437)
37. C. Blanquicett, M. R. Johnson, M. Heslin and R. B. Diasio, Housekeeping gene variability in normal and carcinomatous colorectal and liver tissues: applications in pharmacogenomic gene expression studies. Anal. Biochem. 303, 209-214 (2002). (Pubitemid 34407587)
38. M. R. Johnson, K. Wang, J. B. Smith, M. J. Heslin and R. B. Diasio, Quantitation of dihydropyrimidine dehydrogenase expression by real-time reverse transcription polymerase chain reaction. Anal. Biochem. 278, 175-184 (2000). (Pubitemid 30090740)
39. T. R. Golub, D. K. Slonim, P. Tamayo, C. Huard, M. Gaasenbeek, J. P. Mesirov, H. Coller, M. L. Loh, J. R. Downing and E. S. Lander, Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999).
40. S. Ramaswamy, K. N. Ross, E. S. Lander and T. R. Golub, A molecular signature of metastasis in primary solid tumors. Nat Genet, 33, 49-54 (2003). (Pubitemid 36068681)
41. L. E. Eberly, Multiple linear regression. Methods Mol. Biol. 404, 165-187 (2007).
42. D. F. Flynn and R. E. Goans, Nuclear terrorism: triage and medical management of radiation and combined-injury casualties. Surg. Clin. North Am. 86, 601-636 (2006). (Pubitemid 43884836)
43. P. R. Martin, R. E. Berdychevski, U. Subramanian, W. F. Blakely and P. G. Prasanna, Sample tracking in an automated cytogenetic biodosimetry laboratory for radiation mass casualties. Radiat. Meas. 42, 1119-1124 (2007). (Pubitemid 47430025)
44. E. L. Green, Biology of the Laboratory Mouse, 2nd ed. Dover Publications, New York, 1966.
45. P. K. LeMotte and J. B. Little, A comparison of the lethal effects of intracellular radionuclides in human and rodent cells. Radiat. Res. 95, 359-369 (1983). (Pubitemid 13020926)
46. K. Sankaranarayanan, Evaluation and re-evaluation of genetic radiation hazards in man. II. The arm number hypothesis and the induction of reciprocal translocations in man. Mutat. Res. 35, 371-386 (1976).
47. J. Hageman, B. J. Eggen, T. Rozema, K. Damman, H. H. Kampinga and R. P. Coppes, Radiation and transforming growth factor-beta cooperate in transcriptional activation of the profibrotic plasminogen activator inhibitor-1 gene. Clin. Cancer Res. 11, 5956-5964 (2005). (Pubitemid 41170326)
48. W. Zhao, Y. O'Malley and M. E. Robbins, Irradiation of rat mesangial cells alters the expression of gene products associated with the development of renal fibrosis. Radiat. Res. 152, 160-169 (1999). (Pubitemid 29374598)
49. W. Zhao, Y. O'Malley, S. Wei and M. E. Robbins, Irradiation of rat tubule epithelial cells alters the expression of gene products associated with the synthesis and degradation of extracellular matrix. Int. J. Radiat. Biol. 76, 391-402 (2000). (Pubitemid 30137746)
50. W. Zhao, D. R. Spitz, L. W. Oberley and M. E. Robbins, Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation. Cancer Res. 61, 5537-5543 (2001). (Pubitemid 32694939)
51. C. F. Reilly and R. C. McFall, Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells. J Biol. Chem. 266, 9419-9427 (1991). (Pubitemid 21906673)