Characterization of the solution structure of human serum albumin loaded with a metal porphyrin and fatty acids

Biophysical Journal

Volumn 100, Issue 9, 2011, Pages 2293-2301

  Junk, Matthias J N ^a,b   Spiess, Hans W ^a   Hinderberger, Dariush ^a  

^a MAX PLANCK INSTITUTE FOR POLYMER RESEARCH   (Germany)

^b University of California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959721233     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2011.03.050     Document Type: Article

References (58)

1. Peters, T. 1995. All About Albumin: Biochemistry, Genetics and Medical Applications. Academic Press, San Diego, CA.
2. Carter, D. C., and J. X. Ho. 1994. Structure of serum albumin. Adv. Protein Chem. 45:153-203. (Pubitemid 24139888)
3. Spector, A. A. 1975. Fatty acid binding to plasma albumin. J. Lipid Res. 16:165-179.
4. 13C NMR study. Proc. Natl. Acad. Sci. USA. 81:3718-3722.
5. Bhattacharya, A. A., T. Grüne, and S. Curry. 2000. Crystallographic analysis reveals common modes of binding of medium and long-chain fatty acids to human serum albumin. J. Mol. Biol. 303:721-732.
6. Fasano, M., S. Curry,..., P. Ascenzi. 2005. The extraordinary ligand binding properties of human serum albumin. IUBMB Life. 57:787-796. (Pubitemid 43062399)
7. Curry, S., H. Mandelkow,..., N. Franks. 1998. Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites. Nat. Struct. Biol. 5:827-835. (Pubitemid 28402087)
8. Curry, S., P. Brick, and N. P. Franks. 1999. Fatty acid binding to human serum albumin: new insights from crystallographic studies. Biochim. Biophys. Acta. 1441:131-140. (Pubitemid 29537733)
9. Henzler-Wildman, K., and D. Kern. 2007. Dynamic personalities of proteins. Nature. 450:964-972. (Pubitemid 350273626)
10. Lange, O. F., N.-A. Lakomek,..., B. L. de Groot. 2008. Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution. Science. 320:1471-1475. (Pubitemid 351929422)
11. Karush, F. 1950. Heterogeneity of the binding sites of bovine serum albumin. J. Am. Chem. Soc. 72:2705-2713.
12. Karush, F. 1954. The interaction of optically isomeric dyes with human serum albumin. J. Am. Chem. Soc. 76:5536-5542.
13. Junk, M. J. N., H. W. Spiess, and D. Hinderberger. 2010. The distribution of fatty acids reveals the functional structure of human serum albumin. Angew. Chem. Int. Ed. Engl. 49:8755-8759.
14. Akdogan, Y., M. J. N. Junk, and D. Hinderberger. 2011. Effect of ionic liquids on the solution structure of human serum albumin. Biomacromolecules. 12:1072-1079.
15. Milov, A. D., K. M. Salikhov, and M. D. Shirov. 1981. Application of ENDOR in electron-spin echo for paramagnetic center space distribution in solids. Fiz. Tverd. Tela. 23:975-982.
16. Pannier, M., S. Veit,..., H. W. Spiess. 2000. Dead-time free measurement of dipole-dipole interactions between electron spins. J. Magn. Reson. 142:331-340.
17. Jeschke, G., M. Pannier, and H. W. Spiess. 2000. Double electron-electron resonance. In Biological Magnetic Resonance: Distance Measurements in Biological Systems by EPR. L. J. Berliner, G. R. Eaton, and S. S. Eaton, editors. Kluwer Academic, New York. 493-511.
18. Jeschke, G. 2002. Distance measurements in the nanometer range by pulse EPR. ChemPhysChem. 3:927-932.
19. Jeschke, G. 2002. Determination of the nanostructure of polymer materials by electron paramagnetic resonance spectroscopy. Macromol. Rapid Commun. 23:227-246.
20. Hinderberger, D., O. Schmelz,..., G. Jeschke. 2004. Electrostatic site attachment of divalent counterions to rodlike ruthenium (II) coordination polymers characterized by EPR spectroscopy. Angew. Chem. Int. Ed. Engl. 43:4616-4621. (Pubitemid 39359125)
21. Schiemann, O., and T. F. Prisner. 2007. Long-range distance determinations in biomacromolecules by EPR spectroscopy. Q. Rev. Biophys. 40:1-53. (Pubitemid 47343581)
22. Jeschke, G., and Y. Polyhach. 2007. Distance measurements on spinlabeled biomacromolecules by pulsed electron paramagnetic resonance. Phys. Chem. Chem. Phys. 9:1895-1910.
23. Martin, R. E., M. Pannier,..., H. W. Spiess. 1998. Determination of end-to-end distances in a series of TEMPO diradicals of up to 2.8 nm length with a new four-pulse double electron-electron resonance experiment. Angew. Chem. Int. Ed. 37:2834-2837. (Pubitemid 29008565)
24. He, X. M., and D. C. Carter. 1992. Atomic structure and chemistry of human serum albumin. Nature. 358:209-215.
25. Curry, S. 2009. Lessons from the crystallographic analysis of small molecule binding to human serum albumin. Drug Metab. Pharmacokinet. 24:342-357.
26. Simard, J. R., P. A. Zunszain,..., J. A. Hamilton. 2005. Locating highaffinity fatty acidβinding sites on albumin by x-ray crystallography and NMR spectroscopy. Proc. Natl. Acad. Sci. USA. 102:17958-17963. (Pubitemid 41798484)
27. Simard, J. R., P. A. Zunszain,..., S. Curry. 2006. Location of high and low affinity fatty acid binding sites on human serum albumin revealed by NMR drug-competition analysis. J. Mol. Biol. 361:336-351. (Pubitemid 44092787)
28. Zunszain, P. A., J. Ghuman,..., S. Curry. 2003. Crystal structural analysis of human serum albumin complexed with hemin and fatty acid. BMC Struct. Biol. 3:6. 10.1186/1472-6807-1183-1186.
29. Zunszain, P. A., J. Ghuman,..., S. Curry. 2008. Crystallographic analysis of human serum albumin complexed with 4Z, 15Eβilirubin-IXa. J. Mol. Biol. 381:394-406.
30. Wardell, M., Z. M. Wang,..., D. C. Carter. 2002. The atomic structure of human methemalbumin at 1.9 Å. Biochem. Biophys. Res. Commun. 291:813-819. (Pubitemid 34694348)
31. Petitpas, I., C. E. Petersen,..., S. Curry. 2003. Structural basis of albumin-thyroxine interactions and familial dysalbuminemic hyperthyroxinemia. Proc. Natl. Acad. Sci. USA. 100:6440-6445. (Pubitemid 36666600)
32. Hoard, J. L. 1971. Stereochemistry of hemes and other metalloporphyrins. Science. 174:1295-1302.
33. Narr, E., A. Godt, and G. Jeschke. 2002. Selective measurements of a nitroxide-nitroxide separation of 5 nm and a nitroxide-copper separation of 2.5 nm in a terpyridineβased copper (II) complex by pulse EPR spectroscopy. Angew. Chem. Int. Ed. Engl. 41:3907-3910. (Pubitemid 35278037)
34. van Amsterdam, I. M. C., M. Ubbink,..., M. Huber. 2003. Measurement of a Cu-Cu distance of 26 Å by a pulsed EPR method. Angew. Chem. Int. Ed. Engl. 42:62-64. (Pubitemid 36109498)
35. Bund, T., J. M. Boggs,..., D. Hinderberger. 2010. Copper uptake induces self-assembly of 18.5 kDa myelin basic protein (MBP). Biophys. J. 99:3020-3028.
36. Yang, Z., M. Ji, and S. Saxena. 2010. Practical aspects of copper ionbased double electron-electron resonance distance measurements. Appl. Magn. Reson. 39:487-500.
37. Reference deleted in proof.
38. Larsen, R. G., and D. J. Singel. 1993. Double electron-electron resonance spin-echo modulation: spectroscopic measurement of electron spin pair separations in orientationally disordered solids. J. Chem. Phys. 98:5134-5146.
39. Maryasov, A. G., Y. D. Tsvetkov, and J. Raap. 1998. Weakly coupled radical pairs in solids: ELDOR in ESE structure studies. Appl. Magn. Reson. 14:101-113. (Pubitemid 128657420)
40. Polyhach, Y., A. Godt,..., G. Jeschke. 2007. Spin pair geometry revealed by high-field DEER in the presence of conformational distributions. J. Magn. Reson. 185:118-129. (Pubitemid 46501770)
41. Hertel, M. M., V. P. Denysenkov,..., T. F. Prisner. 2005. Pulsed 180-GHz EPR/ENDOR/PELDOR spectroscopy. Magn. Reson. Chem. 43(Spec no):S248-S255. (Pubitemid 41578522)
42. Denysenkov, V. P., T. F. Prisner,..., M. Bennati. 2006. High-field pulsed electron-electron double resonance spectroscopy to determine the orientation of the tyrosyl radicals in ribonucleotide reductase. Proc. Natl. Acad. Sci. USA. 103:13386-13390. (Pubitemid 44380117)
43. Denysenkov, V. P., D. Biglino,..., M. Bennati. 2008. Structure of the tyrosyl biradical in mouse R2 ribonucleotide reductase from high-field PELDOR. Angew. Chem. Int. Ed. Engl. 47:1224-1227.
44. Savitsky, A., A. A. Dubinskii,..., K. Möbius. 2007. Orientationresolving pulsed electron dipolar high-field EPR spectroscopy on disordered solids: I. Structure of spin-correlated radical pairs in bacterial photosynthetic reaction centers. J. Phys. Chem. B. 111:6245-6262. (Pubitemid 46966232)
45. Schiemann, O., P. Cekan,..., S. T. Sigurdsson. 2009. Relative orientation of rigid nitroxides by PELDOR: beyond distance measurements in nucleic acids. Angew. Chem. Int. Ed. Engl. 48:3292-3295.
46. Margraf, D., B. E. Bode,..., T. F. Prisner. 2007. Conformational flexibility of nitroxide biradicals determined by Xβand PELDOR experiments. Mol. Phys. 105:2153-2160. (Pubitemid 351426631)
47. Bode, B. E., J. Plackmeyer,..., O. Schiemann. 2008. PELDOR measurements on a nitroxide-labeled Cu (II) porphyrin: orientation selection, spin-density distribution, and conformational flexibility. J. Phys. Chem. A. 112:5064-5073.
48. Kay, C. W. M., H. E. Mkami,..., R. W. Evans. 2007. Pulsed ELDOR determination of the intramolecular distance between the metal binding sites in dicupric human serum transferrin and lactoferrin. J. Am. Chem. Soc. 129:4868-4869. (Pubitemid 46651347)
49. Yang, Z., J. Becker, and S. Saxena. 2007. On Cu (II)-Cu (II) distance measurements using pulsed electron-electron double resonance. J. Magn. Reson. 188:337-343. (Pubitemid 47562814)
50. Lovett, J. E., A. M. Bowen,..., J. Harmer. 2009. Structural information from orientationally selective DEER spectroscopy. Phys. Chem. Chem. Phys. 11:6840-6848.
51. Hyde, J. S., M. Pasenkiewicz-Gierula,..., W. E. Antholine. 1990. Pseudofield modulation in EPR spectroscopy. Appl. Magn. Reson. 1:483-496.
52. Stoll, S., and A. Schweiger. 2006. EasySpin, a comprehensive software package for spectral simulation and analysis in EPR. J. Magn. Reson. 178:42-55. (Pubitemid 41774010)
53. Stoll, S., and A. Schweiger. 2003. An adaptive method for computing resonance fields for continuous-wave EPR spectra. Chem. Phys. Lett. 380:464-470.
54. Jeschke, G., A. Bender,..., A. Godt. 2004. Sensitivity enhancement in pulse EPR distance measurements. J. Magn. Reson. 169:1-12.
55. Jeschke, G., V. Chechik,..., H. Jung. 2006. DeerAnalysis 2006 - a comprehensive software package for analyzing pulsed ELDOR data. Appl. Magn. Reson. 30:473-498.
56. Junk, M. J. N., H. W. Spiess, and D. Hinderberger. 2011. DEER in biological multispin-systems: a case study on the fatty acid binding to human serum albumin. J. Magn. Reson. 10.1016/j.jmr.2011.1003.1003.
57. Schweiger, A., and G. Jeschke. 2001. Principles of Pulse Electron Paramagnetic Resonance. Oxford University Press, Oxford, UK.
58. Cunningham, K. L., K. M. McNett,..., D. R. McMillin. 1997. EPR spectra, luminescence data, and radiationless decay processes of copper (II) porphyrins. Inorg. Chem. 36:608-613. (Pubitemid 127471989)