Targeting rapid action of sex-steroid receptors in breast and prostate cancers

Frontiers in Bioscience

Volumn 16, Issue 6, 2011, Pages 2224-2232

  Giovannelli, Pia ^a   Di Donato, Marzia ^a   Giraldi, Tiziana ^a   Migliaccio, Antimo ^a   Castoria, Gabriella ^a   Auricchio, Ferdinando ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

Author keywords

Breast And Prostate Cancers; Review; Signaling Activation; Steroids; Targeted Therapy

Indexed keywords

ANTINEOPLASTIC HORMONE AGONISTS AND ANTAGONISTS; SEX HORMONE; STEROID RECEPTOR;

BIOLOGICAL MODEL; BREAST TUMOR; FEMALE; HUMAN; MALE; METABOLISM; NEOPLASM; PROSTATE TUMOR; REVIEW; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS, HORMONAL; BREAST NEOPLASMS; FEMALE; GONADAL STEROID HORMONES; HUMANS; MALE; MODELS, BIOLOGICAL; NEOPLASMS, HORMONE-DEPENDENT; PROSTATIC NEOPLASMS; RECEPTORS, STEROID; SIGNAL TRANSDUCTION;

EID: 79959715529     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3849     Document Type: Review

References (61)

1. G Castoria, A Migliaccio, L D'Amato, R Di Stasio, A Ciociola, M Lombardi, A Bilancio, M Di Domenico, A de Falco, F Auricchio: Integrating signals between cAMP and MAPK pathways in breast cancer. Front Biosci 13, 1318-1327 (2008) (Pubitemid 351606113)
2. K Fizazi, CN Sternberg, JM Fitzpatrick, RW Watson, M Tabesh: Role of targeted therapy in the treatment of advanced prostate cancer. BJU Int 105, 748-767 (2010)
3. M Beato, P Herrlich, G Schütz: Steroid hormone receptors: many actors in search of a plot. Cell 83, 851-857 (1995) (Pubitemid 26006527)
4. CM Szego, JS Davis: Adenosine 3′,5′-monophosphate in rat uterus: acute elevation by estrogen. Proc Natl Acad Sci U S A 58, 1711-1718 (1967)
5. A Migliaccio, G Castoria, F Auricchio: Src-dependent signalling pathway regulation by sex-steroid hormones: therapeutic implications. Int J Biochem Cell Biol 39, 1343-1348 (2007) (Pubitemid 47031025)
6. A Migliaccio, M Di Domenico, G Castoria, A de Falco, P Bontempo, E Nola, F Auricchio: Tyrosine kinase/p21ras/MAP-kinase pathway activation by estradiolreceptor complex in MCF-7 cells. EMBO J 15, 1292-1300 (1996)
7. A Migliaccio, D Piccolo, G Castoria, M Di Domenico, A Bilancio, M Lombardi, W Gong, M Beato, F Auricchio: Activation of the Src/p21ras/Erk pathway by progesterone receptor via cross-talk with estrogen receptor. EMBO J 17, 2008-2018 (1998) (Pubitemid 28154530)
8. A Migliaccio, G Castoria, M Di Domenico, A de Falco, A Bilancio, M Lombardi, MV Barone, D Ametrano, MS Zannini, C Abbondanza, F Auricchio: Steroid-induced androgen receptor-oestradiol receptor beta-Src complex triggers prostate cancer cell proliferation. EMBO J 19, 5406-5417 (2000)
9. A Migliaccio, M Di Domenico, G Castoria, M Nanayakkara, M Lombardi, A de Falco, A Bilancio, L Varricchio, A Ciociola, F Auricchio: Steroid receptor regulation of epidermal growth factor signaling through Src in breast and prostate cancer cells: steroid antagonist action. Cancer Res 65, 10585-10593 (2005) (Pubitemid 41743754)
10. H Peterziel, S Mink, A Schonert, M Becker, H Klocker, AC Cato: Rapid signalling by androgen receptor in prostate cancer cells. Oncogene 18, 6322-6329 (1999)
11. T Simoncini, AR Genazzani, R De Caterina: Towards a molecular understanding of the atheroprotective effects of estrogens: a review of estrogen effects on endothelial activation. Ital Heart J 1, 104-107 (2000)
12. S Kousteni, T Bellido, LI Plotkin, CA O'Brien, DL Bodenner, L Han, K Han, GB DiGregorio, JA Katzenellenbogen, BS Katzenellenbogen, PK Roberson, RS Weinstein, RL Jilka, SC Manolagas: Nongenotropic, sexnonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity. Cell 104, 719-730 (2001) (Pubitemid 32241022)
13. G Castoria, M Lombardi, MV Barone, A Bilancio, M Di Domenico, D Bottero, F Vitale, A Migliaccio, F Auricchio: Androgen-stimulated DNA synthesis and cytoskeletal changes in fibroblasts by a nontranscriptional receptor action. J Cell Biol 161, 547-556 (2003) (Pubitemid 36578579)
14. G Castoria, L D'Amato, A Ciociola, P Giovannelli, T Giraldi, L Sepe, G Paolella, MV Barone, A Migliaccio, F Auricchio: Androgen-induced cell migration: the role of AR/Filamin A association. PLoS One, in press.
15. G Vallejo, C Ballaré, JL Barañao, M Beato, P Saragüeta: Progestin activation of nongenomic pathways via cross talk of progesterone receptor with estrogen receptor beta induces proliferation of endometrial stromal cells. Mol Endocrinol 19, 3023-3037 (2005) (Pubitemid 41699783)
16. G Castoria, MV Barone, M Di Domenico, A Bilancio, D Ametrano, A Migliaccio, F Auricchio: Non-transcriptional action of oestradiol and progestin triggers DNA synthesis. EMBO J 18, 2500-2510 (1999) (Pubitemid 29213282)
17. G Castoria, A Migliaccio, A Bilancio, M Di Domenico, A de Falco, M Lombardi, R Fiorentino, L Varricchio, MV Barone, F Auricchio: PI3-kinase in concert with Src promotes the S-phase entry of oestradiol-stimulated MCF-7 cells. EMBO J 20, 6050-9 (2001) (Pubitemid 33049280)
18. G Castoria, A Migliaccio, M Di Domenico, M Lombardi, A de Falco, L Varricchio, A Bilancio, MV Barone, F Auricchio: Role of atypical protein kinase C in estradioltriggered G1/S progression of MCF-7 cells. Mol Cell Biol 24, 7643-7653 (2004) (Pubitemid 39121490)
19. C Ballaré, M Uhrig, T Bechtold, E Sancho, M Di Domenico, A Migliaccio, F Auricchio, M Beato: Two domains of the progesterone receptor interact with the estrogen receptor and are required for progesterone activation of the c-Src/Erk pathway in mammalian cells. Mol Cell Biol 1994-2008 (2003) (Pubitemid 36278811)
20. GP Vicent, C Ballaré, AS Nacht, J Clausell, A Subtil- Rodríguez, I Quiles, A Jordan, M Beato: Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3. Mol Cell 24, 367-381 (2006) (Pubitemid 44649285)
21. S Cabodi, L Moro, G Baj, M Smeriglio, P Di Stefano, S Gippone, N Surico, L Silengo, E Turco, G Tarone, P Defilippi: p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells. J Cell Sci 117, 1603-1611 (2004) (Pubitemid 38559834)
22. SR Hammes, ER Levin: Extranuclear steroid receptors: nature and actions. Endocr Rev 28, 726-741 (2007) (Pubitemid 350294293)
23. A Migliaccio, L Varricchio, A de Falco, G Castoria, C Arra, H Yamaguchi, A Ciociola, M Lombardi, R Di Stasio, A Barbieri, A Baldi, MV Barone, E Appella, F Auricchio: Inhibition of the SH3 domain-mediated binding of Src to the androgen receptor and its effect on tumor growth. Oncogene 26, 6619-6629 (2007) (Pubitemid 47573684)
24. L Varricchio, A Migliaccio, G Castoria, H Yamaguchi, A de Falco, M Di Domenico, P Giovannelli, W Farrar, E Appella, F Auricchio: Inhibition of estradiol receptor/Src association and cell growth by an estradiol receptor alpha tyrosine-phosphorylated peptide. Mol Cancer Res 5, 1213-1221 (2007) (Pubitemid 350137116)
25. XD Fu, MS Giretti, C Baldacci, S Garibaldi, M Flamini, AM Sanchez, A Gadducci, AR Genazzani, T Simoncini: Extra-nuclear signaling of progesterone receptor to breast cancer cell movement and invasion through the actin cytoskeleton. PLoS One 3, e2790 (2008)
26. MS Giretti, XD Fu, G De Rosa, I Sarotto, C Baldacci, S Garibaldi, P Mannella, N Biglia, P Sismondi, AR Genazzani, T Simoncini: Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion. PLoS One 3, e2238 (2008)
27. M Qiu, A Olsen, E Faivre, KB Horwitz, CA Lange: Mitogen-activated protein kinase regulates nuclear association of human progesterone receptors. Mol Endocrinol 17, 628-642 (2003) (Pubitemid 36403575)
28. M Lombardi, G Castoria, A Migliaccio, MV Barone, R Di Stasio, A Ciociola, D Bottero, H Yamaguchi, E Appella, F Auricchio: Hormone-dependent nuclear export of estradiol receptor and DNA synthesis in breast cancer cells. J Cell Biol 182, 327-340 (2008)
29. M Le Romancer, I Treilleux, N Leconte, Y Robin- Lespinasse, S Sentis, K Bouchekioua-Bouzaghou, S Goddard, S Gobert-Gosse, L Corbo: Regulation of estrogen rapid signaling through arginine methylation by PRMT1. Mol Cell 31, 212-221 (2008) (Pubitemid 352005820)
30. RC Hovey, JF Trott, BK Vonderhaar: Establishing a framework for the functional mammary gland: from endocrinology to morphology. J Mammary Gland Biol Neoplasia 7, 17-38 (2002) (Pubitemid 38420779)
31. SZ Haslam, LJ Counterman, KA Nummy: Effects of epidermal growth factor, estrogen, and progestin on DNA synthesis in mammary cells in vivo are determined by the developmental state of the gland. J Cell Physiol 155, 72-78 (1993) (Pubitemid 23109058)
32. V Speirs, PJ Carder, S Lane, D Dodwell, MR Lansdown, AM Hanby: Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol 5, 174-181 (2004) (Pubitemid 38262850)
33. F Holst, PR Stahl, C Ruiz, O Hellwinkel, Z Jehan, M Wendland, A Lebeau, L Terracciano, K Al-Kuraya, F Jänicke, G Sauter, R Simon: Estrogen receptor alpha (ESR1) gene amplification is frequent in breast cancer. Nat Genet 39, 655-660 (2007) (Pubitemid 46676104)
34. A Migliaccio, M Pagano, F Auricchio: Immediate and transient stimulation of protein tyrosine phosphorylation by estradiol in MCF-7 cells. Oncogene 8, 2183-2191 (1993) (Pubitemid 23226952)
35. R Kumar, RA Wang, A Mazumdar, AH Talukder, M Mandal, Z Yang, R Bagheri-Yarmand, A Sahin, G Hortobagyi, L Adam, CJ Barnes, RK Vadlamudi: A naturally occurring MTA1 variant sequesters oestrogen receptor-alpha in the cytoplasm. Nature 418, 654-657 (2002)
36. CA Lange, D Yee: Progesterone and breast cancer. Womens Health (Lond Engl) 4, 151-62 (2008) (Pubitemid 351513635)
37. GP Vicent, AS Nacht, R Zaurín, C Ballaré, J Clausell, M Beato: Minireview: Role of Kinases and Chromatin Remodeling in Progesterone Signaling to Chromatin. Mol Endocrinol (2010)
38. V Boonyaratanakornkit, MP Scott, V Ribon, L Sherman, SM Anderson, JL Maller, WT Miller, DP Edwards: Progesterone receptor contains a proline-rich motif that directly interacts with SH3 domains and activates c-Src family tyrosine kinases. Mol Cell 8, 269-280 (2001) (Pubitemid 32831545)
39. V Boonyaratanakornkit, E McGowan, L Sherman, MA Mancini, BJ Cheskis, DP Edwards: The role of extranuclear signaling actions of progesterone receptor in mediating progesterone regulation of gene expression and the cell cycle. Mol Endocrinol 21, 359-375 (2007) (Pubitemid 46184890)
40. RP Carnevale, CJ Proietti, M Salatino, A Urtreger, G Peluffo, DP Edwards, V Boonyaratanakornkit, EH Charreau, E Bal de Kier Joffé, R Schillaci, PV Elizalde: Progestin effects on breast cancer cell proliferation, proteases activation, and in vivo development of metastatic phenotype all depend on progesterone receptor capacity to activate cytoplasmic signaling pathways. Mol Endocrinol 21, 1335-1358 (2007) (Pubitemid 46984741)
41. EJ Faivre, CA Lange: Progesterone receptors upregulate Wnt-1 to induce epidermal growth factor receptor transactivation and c-Src-dependent sustained activation of Erk1/2 mitogen-activated protein kinase in breast cancer cells. Mol Cell Biol 27, 466-480 (2007) (Pubitemid 46080117)
42. S Yeh, YC Hu, PH Wang, C Xie, Q Xu, MY Tsai, Z Dong, RS Wang, TH Lee, C Chang: Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor. J Exp Med 198, 1899-1908 (2003) (Pubitemid 38032122)
43. AS Doane, M Danso, P Lal, M Donaton, L Zhang, C Hudis, WL Gerald: An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen. Oncogene 25, 3994-4008 (2006) (Pubitemid 43990755)
44. GP Risbridger, ID Davis, SN Birrell, WD Tilley: Breast and prostate cancer: more similar than different. Nat Rev Cancer 10, 205-212 (2010)
45. ER Levin: Bidirectional signaling between the estrogen receptor and the epidermal growth factor receptor. Mol Endocrinol 17, 309-317 (2003) (Pubitemid 36315626)
46. WA Ricke, SJ McPherson, JJ Bianco, GR Cunha, Y Wang, GP Risbridger. Prostatic hormonal carcinogenesis is mediated by in situ estrogen production and estrogen receptor alpha signaling. FASEB J 22, 1512-1520 (2008) (Pubitemid 351656791)
47. D Price, B Stein, P Sieber, R Tutrone, J Bailen, E Goluboff, D Burzon, D Bostwick, M Steiner: Toremifene for the prevention of prostate cancer in men with high grade prostatic intraepithelial neoplasia: results of a doubleblind, placebo controlled, phase IIB clinical trial. J Urol 176, 965-970 (2006)
48. G Pandini, R Mineo, F Frasca, CT Jr Roberts, M Marcelli, R Vigneri, A Belfiore: Androgens up-regulate the insulin-like growth factor-I receptor in prostate cancer cells. Cancer Res 65, 1849-1857 (2005) (Pubitemid 40478613)
49. G Pandini, T Wurch, B Akla, N Corvaia, A Belfiore, L Goetsch: Functional responses and in vivo anti-tumour activity of h7C10: a humanised monoclonal antibody with neutralising activity against the insulin-like growth factor-1 (IGF-1) receptor and insulin/IGF-1 hybrid receptors. Eur J Cancer 43, 1318-27 (2007) (Pubitemid 46720250)
50. M Genua, G Pandini, D Sisci, G Castoria, M Maggiolini, R Vigneri, A Belfiore: Role of cyclic AMP response element-binding protein in insulin-like growth factor-i receptor up-regulation by sex steroids in prostate cancer cells. Cancer Res 69, 7270-7277 (2009)
51. L Jerome, L Shiry, B Leyland-Jones: Deregulation of the IGF axis in cancer: epidemiological evidence and potential therapeutic interventions. Endocr Relat Cancer 10, 561-578 (2003) (Pubitemid 38094891)
52. E Unni, S Sun, B Nan, MJ McPhaul, B Cheskis, MA Mancini, M Marcelli: Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res 64, 7156-7168 (2004) (Pubitemid 39331031)
53. DM Ozanne, ME Brady, S Cook, L Gaughan, DE Neal, CN Robson: Androgen receptor nuclear translocation is facilitated by the f-actin cross-linking protein filamin. Mol Endocrinol 14, 1618-1626 (2000)
54. CJ Loy, KS Sim, EL Yong: Filamin-A fragment localizes to the nucleus to regulate androgen receptor and coactivator functions. Proc Natl Acad Sci U S A 100, 4562-4567 (2003) (Pubitemid 36457770)
55. Y Wang, JI Kreisberg, RG Bedolla, M Mikhailova, RW deVere White, PM Ghosh: A 90 kDa fragment of filamin A promotes Casodex-induced growth inhibition in Casodex-resistant androgen receptor positive C4-2 prostate cancer cells. Oncogene 26, 6061-6070 (2007) (Pubitemid 47373811)
56. RG Bedolla, Y Wang, A Asuncion, K Chamie, S Siddiqui, MM Mudryj, TJ Prihoda, J Siddiqui, AM Chinnaiyan, R Mehra, RW de Vere White, PM Ghosh: Nuclear versus cytoplasmic localization of filamin A in prostate cancer: immunohistochemical correlation with metastases. Clin Cancer Res 15, 788-796 (2009)
57. B Cinar, NK Mukhopadhyay, G Meng, MR Freeman: Phosphoinositide 3-kinase-independent nongenomic signals transit from the androgen receptor to Akt1 in membrane raft microdomains. J Biol Chem 282, 29584-29593 (2007) (Pubitemid 350043392)
58. NC Bennett, RA Gardiner, JD Hooper, DW Johnson, GC Gobe: Molecular cell biology of androgen receptor signalling. Int J Biochem Cell Biol 42, 813-827 (2010)
59. G Castoria, A Migliaccio, F Auricchio: Signalingdependent nuclear export of estradiol receptor controls cell cycle progression in breast cancer cells. Mol Cell Endocrinol 308, 26-31 (2009)
60. A Joliot, A Prochiantz: Transduction peptides: from technology to physiology. Nat Cell Biol 6, 189-196 (2004) (Pubitemid 38344356)
61. TJ Gibson: Cell regulation: determined to signal discrete cooperation. Trends Biochem Sci 34, 471-482 (2009)