Extra-nuclear signalling of estrogen receptor to breast cancer cytoskeletal remodelling, migration and invasion

PLoS ONE

Volumn 3, Issue 5, 2008, Pages

  Giretti, Maria Silvia ^a   Fu, Xiao Dong ^a   De Rosa, Giovanni ^b   Sarotto, Ivana ^b   Baldacci, Chiara ^a   Garibaldi, Silvia ^a   Mannella, Paolo ^a   Biglia, Nicoletta ^b   Sismondi, Piero ^b   Genazzani, Andrea Riccardo ^a   Simoncini, Tommaso ^a  

^a UNIVERSITY OF PISA   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN BINDING PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; G ACTIN; MOESIN; RHO KINASE; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ACTIN;

ARTICLE; BREAST CANCER; BREAST CARCINOMA; BREAST FIBROADENOMA; CELL ACTIVATION; CELL INVASION; CELL MIGRATION; CELL MOTION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; DOWNSTREAM PROCESSING; HUMAN; HUMAN CELL; HUMAN TISSUE; MEMBRANE STRUCTURE; MOLECULAR DYNAMICS; PROTEIN PROTEIN INTERACTION; PSEUDOPODIUM; SIGNAL TRANSDUCTION; WILD TYPE; BREAST TUMOR; CANCER INVASION; CELL NUCLEUS; METABOLISM; METASTASIS; PATHOLOGY; TUMOR CELL LINE;

ACTINS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; CYTOSKELETON; HUMANS; MICROFILAMENT PROTEINS; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION;

EID: 48249111803     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002238     Document Type: Article

References (28)

1. Jemal A, Siegel R, Ward E, Murray T, Xu J, et al. (2007) Cancer statistics, 2007. CA Cancer J Clin 57: 43-66.
2. Ricketts D, Turnbull L, Ryall G, Bakhshi R, Rawson NS, et al. (1991) Estrogen and progesterone receptors in the normal female breast. Cancer Res 51: 1817-1822.
3. Kelsey JL, Gammon MD, John EM (1993) Reproductive factors and breast cancer. Epidemiol Rev 15: 36-47.
4. Yager JD, Davidson NE (2006) Estrogen carcinogenesis in breast cancer. N Engl J Med 354: 270-282.
5. Acconcia F, Barnes CJ, Kumar R (2006) Estrogen and tamoxifen induce cytoskeletal remodeling and migration in endometrial cancer cells. Endocrinology 147: 1203-1212.
6. Pollard TD, Borisy GG (2003) Cellular Motility driven by assembly and disassembly of actin filaments. Cell 112: 453-465.
7. Song RX. McPherson RA, Adam L, Bao Y, Shupnik M, et al. (2002) Linkage of rapid estrogen action to MAPK activation by ERalpha-Shc association and Shc pathway activation. Mol Endocrinol 16: 116-127.
8. Simoncini T, Scorticati C, Mannella P, Fadiel A, Giretti MS, et al. (2006) Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/mocsin pathway. Mol Endocrinol 20: 1756-1771.
9. Tsukita S, Yonemura S (1999) Cortical actin organization: lessons from ERM (ezrin/radixin/moesin) proteins. J Biol Chem 274: 34507-34510.
10. Bretscher A, Reczek D, Berryman M (1997) Ezrin: a protein requiring conformational activation to link microfilaments to the plasma membrane in the assembly of cell surface structures. J Cell Sci 110 (Pt 24): 3011-3018.
11. Yu Y, Khan J, Khanna C, Helman L, Meltzer PS, et al. (2004) Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators. Nat Med 10: 175-181.
12. Khanna C, Wan X, Bose S, Cassaday R, Olomu O, et al. (2004) The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10: 182-186.
13. Elliott BE, Meens JA, SenGupta SK, Louvard D, Arpin M (2005) The membrane cytoskeletal crosslinker ezrin is required for metastasis of breast carcinoma cells. Breast Cancer Res 7: R365-373.
14. Song J, Fadiel A, Edusa V, Chen Z, So J, et al. (2005) Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen. Cancer Lett 220: 57-65.
15. Oshiro N, Fukata, Y, Kaibuchi K (1998) Phosphorylation of moesin by rhoassociated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem 273: 34663-34666.
16. Matsui T, Maeda M, Doi Y, Yonemura S, Amano M, et al. (1998) Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head-to-tail association. J Cell Biol 140: 647-657.
17. Long X, Nephew KP (2006) Fulvestrant (ICI 182,780)-dependent interacting proteins mediate immobilization and degradation of estrogen receptor-alpha. J Biol Chem 281: 9607-9615.
18. Kraichely DM, Sun J, Katzenellenbogen JA, Katzenellenbogen BS (2000) Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members. Endocrinology 141: 3534-3545.
19. Meyers MJ, Sun J, Carlson KE, Marriner GA, Katzenellenbogen BS, et al. (2001) Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues. J Med Chem 11: 4230-4251.
20. Jeon S, Kim S, Park JB, Suh PG, Kim YS, et al. (2002) RhoA and Rho kinase-dependent phosphorylation of moesin at Thr-558 in hippocampal neuronal cells by glutamate. J Biol Chem 277: 16576-16584.
21. Platet N, Cathiard AM, Gleizes M, Garcia M (2004) Estrogens and their receptors in breast cancer progression: a dual role in cancer proliferation and invasion. Crit Rev Oncol Hematol 51: 55-67.
22. Giannone G, Dubin-Thader BJ, Dobereiner HG, Kieffer N, Bresnick AR, et al. (2004) Periodic lamellipodial contractions correlate with rearward actin waves. Cell 116: 431-443.
23. Simoncini T, Genazzani AR (2003) Non-genomic actions of sex steroid hormones. Eur J Endocrinol 148: 281-292.
24. Pawlak G, Helfman DM (2001) Cytoskeletal changes in cell transformation and tumorigenesis. Curr Opin Genet Dev 11: 41-47.
25. Chen Z, Fadiel A, Feng Y, Ohtani K, Rutherford T, et al. (2001) Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor. Cancer 92: 3068-3075.
26. Carmeci C, Thompson DA, Kuang WW, Lightdale N, Furthmayr H, et al. (1998) Moesin expression is associated with the estrogen receptor-negative breast cancer phenotype. Surgery 124: 211-217.
27. Sarrio D, Rodriguez-Pinilla SM, Dotor A, Calero F, Hardisson D, et al. (2006) Abnormal ezrin localization is associated with clinicopathological features in invasive breast carcinomas. Breast Cancer Res Treat.
28. Iontcheva I, Amar S, Zawawi KH, Kantarci A, Van Dyke TE (2004) Role for moesin in lipopolysaccharide-stimulated signal transduction. Infect Immun 72: 2312-2320.