Role of cyclic AMP response element-binding protein in insulin-like growth factor-I receptor up-regulation by sex steroids in prostate cancer cells

Cancer Research

Volumn 69, Issue 18, 2009, Pages 7270-7277

  Genua, Marco ^a   Pandini, Giuseppe ^a   Sisci, Diego ^b   Castoria, Gabriella ^c   Maggiolini, Marcello ^b   Vigneri, Riccardo ^a   Belfiore, Antonino ^d  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF CALABRIA   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ESTROGEN; ESTROGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C; SOMATOMEDIN C RECEPTOR;

ARTICLE; BINDING SITE; CANCER CELL CULTURE; CELL STIMULATION; CELL STRAIN LNCAP; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE ACTIVATION; GENE SEQUENCE; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; ONCOGENE SRC; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN BINDING; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; UPREGULATION;

CELL LINE, TUMOR; CREB-BINDING PROTEIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HUMANS; MALE; METRIBOLONE; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; PROSTATIC NEOPLASMS; RECEPTOR, IGF TYPE 1; TRANSFECTION; UP-REGULATION;

EID: 70349747010     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-09-0088     Document Type: Article

References (40)

1. Trapman J, Brinkmann AO. The androgen receptor in prostate cancer. Pathol Res Pract 1996;192:752-760
2. Lau KM, LaSpina M, Long J, Ho SM. Expression of estrogen receptor (ER)-α and ER-β in normal and malignant prostatic epithelial cells: regulation by methylation and involvement in growth regulation. Cancer Res 2000;60:3175-3182 (Pubitemid 30407914)
3. Leav I, Lau KM, Adams JY, et al. Comparative studies of the estrogen receptors β and α and the androgen receptor in normal human prostate glands, dysplasia, and in primary and metastatic carcinoma. Am J Pathol 2001;159:79-92. (Pubitemid 33704195)
4. Lai JS, Brown LG, True LD, et al. Metastases of prostate cancer express estrogen receptor-β. Urology 2004;64:814-820 (Pubitemid 39446081)
5. Kim IY, Seong do H, Kim BC, et al. Raloxifene, a selective estrogen receptor modulator, induces apoptosis in androgen-responsive human prostate cancer cell line LNCaP through an androgen-independent pathway. Cancer Res 2002;62:3649-3653
6. LeRoith D, Roberts CT, Jr. The insulin-like growth factor system and cancer. Cancer Lett 2003;195:127-137
7. Baserga R, Peruzzi F, Reiss K. The IGF-1 receptor in cancer biology. Int J Cancer 2003;107:873-877
8. Nickerson T, Chang F, Lorimer D, Smeekens SP, Sawyers CL, Pollak M. In vivo progression of LAPC-9 and LNCaP prostate cancer models to androgen independence is associated with increased expression of insulin-like growth factor I (IGF-I) and IGF-I receptor (IGF-IR). Cancer Res 2001;61:6276-6280
9. Hellawell GO, Turner GD, Davies DR, Poulsom R, Brewster SF, Macaulay VM. Expression of the type 1 insulin-like growth factor receptor is up-regulated in primary prostate cancer and commonly persists in metastatic disease. Cancer Res 2002;62:2942-2950 (Pubitemid 34525783)
10. Krueckl SL, Sikes RA, Edlund NM, et al. Increased insulin-like growth factor I receptor expression and signaling are components of androgen-independent progression in a lineage-derived prostate cancer progression model. Cancer Res 2004;64:8620-8629
11. DiGiovanni J, Kiguchi K, Frijhoff A, et al. Deregulated expression of insulin-like growth factor 1 in prostate epithelium leads to neoplasia in transgenic mice. Proc Natl Acad Sci U S A 2000;97:3455-3460 (Pubitemid 30183324)
12. Burfeind P, Chernicky CL, Rininsland F, Ilan J. Antisense RNA to the type I insulin-like growth factor receptor suppresses tumor growth and prevents invasion by rat prostate cancer cells in vivo . Proc Natl Acad Sci U S A 1996;93:7263-7268 (Pubitemid 26243537)
13. Goya M, Miyamoto S, Nagai K, et al. Growth inhibition of human prostate cancer cells in human adult bone implanted into nonobese diabetic/severe combined immunodeficient mice by a ligand-specific antibody to human insulin-like growth factors. Cancer Res 2004;64:6252-6258 (Pubitemid 39129428)
14. Pandini G, Mineo R, Frasca F, et al. Androgens upregulate the insulin-like growth factor-I receptor in prostate cancer cells. Cancer Res 2005;65:1849-1857 (Pubitemid 40478613)
15. Pandini G, Genua M, Frasca F, Squatrito S, Vigneri R, Belfiore A. 17h-Estradiol up-regulates the insulin-like growth factor receptor through a nongenotropic pathway in prostate cancer cells. Cancer Res 2007;67:8932-8941 (Pubitemid 47437471)
16. Unni E, Sun S, Nan B, et al. Changes in androgen receptor nongenotropic signaling correlate with transition of LNCaP cells to androgen independence. Cancer Res 2004;64:7156-7168 (Pubitemid 39331031)
17. Migliaccio A, Castoria G, Di Domenico M, et al. Sex steroid hormones act as growth factors. J Steroid Biochem Mol Biol 2002;83:31-35 (Pubitemid 37040639)
18. Kousteni S, Chen JR, Bellido T, et al. Reversal of bone loss in mice by nongenotropic signaling of sex steroids. Science 2002;298:843-846
19. Kousteni S, Han L, Chen JR, et al. Kinase-mediated regulation of common transcription factors accounts for the bone-protective effects of sex steroids. J Clin Invest 2003;111:1651-1664 (Pubitemid 38057747)
20. Abramovitch R, Tavor E, Jacob-Hirsch J, et al. A pivotal role of cyclic AMP-responsive element binding protein in tumor progression. Cancer Res 2004;64:1338-1346 (Pubitemid 38235602)
21. Aronica SM, Kraus WL, Katzenellenbogen BS. Estrogen action via the cAMP signaling pathway: stimulation of adenylate cyclase and cAMP-regulated gene transcription. Proc Natl Acad Sci U S A 1994;91:8517-8521
22. Yamamoto KK, Gonzalez GA, Biggs WH, III,Montminy MR. Phosphorylation- induced binding and transcriptional efficacy of nuclear factor CREB. Nature 1988;334:494-498
23. Gonzalez GA, Yamamoto KK, Fischer WH, et al. A cluster of phosphorylation sites on the cyclic AMP-regulated nuclear factor CREBpredicted by its sequence. Nature 1989;337:749-752
24. Cheng J, Watkins SC, Walker WH. Testosterone activates mitogen-activated protein kinase via Src kinase and the epidermal growth factor receptor in Sertoli cells. Endocrinology 2007;148:2066-2074 (Pubitemid 46997076)
25. Wang YN, Chen YJ, Chang WC. Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Mol Pharmacol 2006;69:85-98.
26. Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREBkinase. Science 1996;273:959-963 (Pubitemid 26275173)
27. Sturgill TW, Ray LB, Erikson E, Maller JL. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature 1988;334:715-718 (Pubitemid 18197572)
28. Frodin M, Gammeltoft S. Role and regulation of 90 kDa ribosomal S6 kinase (RSK) in signal transduction. Mol Cell Endocrinol 1999;151:65-77. (Pubitemid 29278816)
29. Lee SJ, Campomanes CR, Sikat PT, Greenfield AT, Allen PB, McEwen BS. Estrogen induces phosphorylation of cyclic AMP response element binding (pCREB) in primary hippocampal cells in a time-dependent manner. Neuroscience 2004;124:549-560
30. Wade CB, Dorsa DM. Estrogen activation of cyclic adenosine 5′-monophosphate response element-mediated transcription requires the extracellularly regulated kinase/mitogen-activated protein kinase pathway. Endocrinology 2003;144:832-838
31. Benbrook DM, Jones NC. Heterodimer formation between CREBan d JUN proteins. Oncogene 1990;5:295-302. (Pubitemid 20102576)
32. Cooke DW, Bankert LA, Roberts CT, Jr., LeRoith D, Casella SJ. Analysis of the human type I insulin-like growth factor receptor promoter region. Biochem Biophys Res Commun 1991;177:1113-1120
33. Werner H, Bach MA, Stannard B, Roberts CT, Jr., LeRoith D. Structural and functional analysis of the insulin-like growth factor I receptor gene promoter. Mol Endocrinol 1992;6:1545-1558
34. Werner H, Re GG, Drummond IA, et al. Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product. Proc Natl Acad Sci U S A 1993;90:5828-5832 (Pubitemid 23176256)
35. Idelman G, Glaser T, Roberts CT, Jr., Werner H. WT1-53 interactions in insulin-like growth factor-I receptor gene regulation. J Biol Chem 2003;278:3474-3482 (Pubitemid 36801264)
36. Werner H, Shalita-Chesner M, Abramovitch S, Idelman G, Shaharabani-Gargir L, Glaser T. Regulation of the insulin-like growth factor-I receptor gene by oncogenes and antioncogenes: implications in human cancer. Mol Genet Metab 2000;71:315-320 (Pubitemid 30749554)
37. Glait C, Tencer L, Ravid D, Sarfstein R, Liscovitch M, Werner H. Caveolin-1 up-regulates IGF-I receptor gene transcription in breast cancer cells via Sp1- and p53-dependent pathways. Exp Cell Res 2006;312:3899-3908 (Pubitemid 44633889)
38. Monnier D, Boutillier AL, Giraud P, et al. Insulin-like growth factor-I stimulates c-fos and c-jun transcription in PC12 cells. Mol Cell Endocrinol 1994;104:139-145 (Pubitemid 24253795)
39. Ginty DD, Bonni A, Greenberg ME. Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell 1994;77:713-725 (Pubitemid 24175607)
40. Linnerth NM, Baldwin M, Campbell C, Brown M, McGowan H, Moorehead RA. IGF-II induces CREB phosphorylation and cell survival in human lung cancer cells. Oncogene 2005;24:7310-7319 (Pubitemid 41622235)