Trauma-hemorrhage and its effects on the endothelium

Endothelial Biomedicine

Volumn , Issue , 2007, Pages 1513-1522

  Yokoyama, Yukihiro ^a   Chaudry, Irshad H ^b  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 79959712701     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1017/CBO9780511546198.165     Document Type: Chapter

References (98)

1. Ayala A, Wang P, Ba ZF, et al. Differential alterations in plasma IL-6 and TNF levels following trauma and hemorrhage. Am J Physiol. 1991;260:R167-R171.
2. Boldt J, Menges T, Kuhn D, et al. Alterations in circulating vasoactive substances in the critically ill -a comparison between survivors and non-survivors. Intensive Care Med. 1995;21(3):218-225.
3. Harrigan C, Lucas CE, Ledgerwood AM. The effect of hemorrhagic shock on the clotting cascade in injured patients. J Trauma. 1989;29(10):1416-1421; discussion: 1421-1422.
4. Aird WC. The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood. 2003;101(10):3765-3777.
5. Williams JJ, Moalli R, Calista C, Herndon JH. Pulmonary endothelial injury and altered fibrinolysis after femur fracture in rabbits. JOrthop Trauma. 1990;4(3):303-308.
6. Ashburn JH, Baveja R, Kresge N, et al. Remote trauma sensitizes hepatic microcirculation to endothelin via caveolin inhibition of eNOS activity. Shock. 2004;22(2):120-130.
7. Davis JM, Stevens JM, Peitzman A, et al. Neutrophil migratory activity in severe hemorrhagic shock. Circ Shock. 1983;10:199-204.
8. Bitterman H, Smith BA, Lefer AM. Beneficial actions ofantago-nism of peptide leukotrienes in hemorrhagic shock. Circ Shock. 1988;24:159-168.
9. Ikai I, Ozaki N, Shimahara Y, et al. Significance of hepatic mitochondrial redox potential on the concentrations of plasma amino acids following hemorrhagic shock in rats. Circ Shock. 1989;27:63-72.
10. Schumer W. Localization ofthe energy pathway block in shock. Surgery. 1968;64:55-59.
11. Campion DS, Lynch LJ, Rector FC, et al. Effect of hemorrhagic shock on transmembrane potential. Surgery. 1969;66:1051-1059.
12. Drucker WR, DeKiewiet JC. Glucoseuptakebydiaphragmsfrom rats subjectedto hemorrhagic shock. Am J Physiol. 1964;206:317-320.
13. Weil MH, Afifi AA. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure. Circulation. 1970;41:989-1001.
14. van der Meer C, Valkenburg PW, Snijders PM, et al. A method for hemorrhagic shock in the rat. J Pharmacol Methods. 1987;17:75-82.
15. Chaudry IH, Wang P, Singh G, et al. Rat and mouse models of hypovolemic-traumatic shock. In: Schlag G, Redl H, eds. Pathophysiology of Shock, Sepsis and Organ Failure. Berlin: Springer-Verlag; 1993:371-383.
16. Schwacha MG, Wang P, Chaudry IH. Trauma models for studying the influence of gender and aging. In: Souba W, Wilmore D, eds. Surgical Research. New York: Academic Press; 2001:357-366.
17. Holden WD, Depalma RG, Drucker WR, McKalen A. Ultra-structural changes in hemorrhagic shock: electron microscopic study of liver, kidney and striated muscle cell in rats. Ann Surg. 1965;162:517-536.
18. Mela L, Bacalzo LV Jr, Miller LD. Defective oxidative metabolism of rat liver mitochondria in hemorrhagic and endotoxin shock. Am J Physiol. 1971;220:571-577.
19. LePage GA. The effects ofhemorrhage on tissue metabolites. Am J Physiol. 1946;147:446-453.
20. Abraham E, Richmond JN, Chang YH. Effects ofhemorrhage on interleukin-1 production. Circ Shock. 1988;25:33-40.
21. Sayeed MM, Baue AE. Mitochondrial metabolism of succinate, f-hydroxybutyrate, and a-ketoglutarate in hemorrhagic shock. Am J Physiol. 1971;220:1275-1281.
22. Chaudry IH, Sayeed MM, Baue AE. Effect ofhemorrhagic shock in tissue adenine nucleotides in conscious rats. Can J Physiol Pharmacol. 1974;52:131-137.
23. Machiedo GW, Ghuman S, Rush BF, et al. The effect of ATP-MgCl2 infusion on hepatic cell permeability and metabolism after hemorrhagic shock. Surgery. 1981;90:328-335.
24. Rush BF, Redan JA, Flanagan JJ, et al. Does the bacteremia observed in hemorrhagic shock have clinical significance? A study in germ-free animals. Ann Surg. 1989;210:342-347.
25. Stephan RN, Kupper TS, Geha AS, et al. Hemorrhage without tissue trauma produces immunosuppression and enhances susceptibility to sepsis. Arch Surg. 1987;122:62-68.
26. Ertel W, Morrison MH, Ayala A, et al. Blockade ofprostaglandin production increases cachectin synthesis and prevents depression ofmacrophage functions following hemorrhagic shock. Ann Surg. 1991;213:265-271.
27. Wang P, Singh G, Rana MW, et al. Preheparinization improves organ function following hemorrhage and resuscitation. Am J Physiol. 1990;259:R645-R650.
28. Crowell JW, Read WI. In vivo coagulation -a probable cause of irreversible shock. Am J Physiol. 1955;183:565-569.
29. Akgur FM, Zibari GB, McDonald JC, et al. Kinetics of P-selectin expression in regional vascular beds after resuscitation ofhemor-rhagic shock: a clue to the mechanism of multiple system organ failure. Shock. 2000;13(2):140-144.
30. Sun LL, Ruff P, Austin B, et al. Early up-regulation of intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 expression in rats with hemorrhagic shock and resuscitation. Shock. 1999;11(6):416-422.
31. Hawrylowicz CM, Howells GL, Feldmann M. Platelet-derived interleukin 1 induces human endothelial adhesion molecule expression and cytokine production. J Exp Med. 1991;174(4): 785-790.
32. Vedder NB, Winn RK, Rice CL, et al. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein CD18 reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. J Clin Invest. 1988;31:939-944.
33. Maier M, Strobele H, Voges J, et al. Attenuation ofleukocyte adhesion by recombinant TNF-binding protein after hemorrhagic shock in the rat. Shock. 2003;19(5):457-461.
34. Powers KA, Kapus A, Khadaroo RG, et al. 25% Albumin modulates adhesive interactions between neutrophils and the endothelium following shock/resuscitation. Surgery. 2002;132(2):391-398.
35. Cockerill GW, McDonald MC, Mota-Filipe H, et al. High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock. FASEBJ. 2001;15(11):1941-1952.
36. Bertuglia S, Giusti A. Influence of ACTH-(1-24) and plasma hyperviscosity on free radical production and capillary perfusion after hemorrhagic shock. Microcirculation. 2004;11(3):227-238.
37. Angle N, Hoyt DB, Cabello-Passini R, et al. Hypertonic saline resuscitation reduces neutrophil margination by suppressing neutrophil Lselectin expression. J Trauma. 1998;45(1):7-12; discussion: 12-13.
38. Barroso-Aranda J, Schmid-Schonbein GW. Pentoxifylline pretreatment decreases the pool of circulating activated neutrophils, in-vivo adhesion to endothelium, and improves survival from hemorrhagic shock. Biorheology. 1990;27(3-4):401-418.
39. Balogh Z, Wolfard A, Szalay L, et al. Dalteparin sodium treatment during resuscitation inhibits hemorrhagic shock-induced leukocyte rolling and adhesion in the mesenteric microcirculation. J Trauma. 2002;52(6):1062-9; discussion: 1070.
40. Wang P, Ba ZF, Reich SS, et al. Effects of a non-anticoagulant heparin on cardiovascular and hepatocellular function after hemorrhagic shock. Am J Physiol. 1996;270:H1294-H1302.
41. Myers SI, Hernandez R. Oxygen free radical regulation of rat splanchnic blood flow. Surgery. 1992;112(2):347-354.
42. Akgur FM, Brown MF, Zibari GB, et al. Role of superoxide in hemorrhagic shock-induced P-selectin expression. Am J Physiol Heart Circ Physiol. 2000;279(2):H791-H797.
43. Myers SI, Hernandez R. Role of oxygen-derived free radicals on rat splanchnic eicosanoid production during acute hemorrhage. Prostaglandins. 1992;44(1):25-36.
44. Zakaria el R, Garrison RN, Spain DA, Harris PD. Impairment of endothelium-dependent dilation response after resuscitation from hemorrhagic shock involved postreceptor mechanisms. Shock. 2004;21(2):175-181.
45. Wang P, Ba ZF, Chaudry IH. Endothelium-dependent relaxation is depressed at the macro-and microcirculatory levels during sepsis. Am J Physiol. 1995;269:R988-R994.
46. Wang P, Wood TJ, Zhou M, et al. Inhibition ofthe biologic activity of tumor necrosis factor maintains vascular endothelial cell function during hyperdynamic sepsis. J Trauma. 1996;40:694-701.
47. Ertel W, Morrison MH, Ayala A, Chaudry IH. Hypoxemia in the absence of blood loss or significant hypotension causes inflammatory cytokine release. Am J Physiol. 1995;269:R160-R166.
48. Knoferl M, Jarrar D, Schwacha MG, et al. Severe hypoxemia in the absence of blood loss causes a gender dimorphic immune response. Am J Physiol. 2000;279:C2004-C2010.
49. Williams JM, Pearce WJ. Age-dependent modulation of endothelium-dependent vasodilatation by chronic hypoxia in ovine cranial arteries. JAppl Physiol. 2006;100(1):22-232.
50. Wang P, Ba ZF, Chaudry IH. Endothelial cell dysfunction occurs after hemorrhage in nonheparinized but not in preheparinized models. J SurgRes. 1993;54:499-506.
51. Szabo C, Farago M, Horvath I, et al. Hemorrhagic hypotension impairs endothelium-dependent relaxations in the renal artery ofthe cat. Circ Shock. 1992;36:238-241.
52. Quan L, Sobey CG. Selective effects of subarachnoid hemorrhage on cerebral vascular responses to 4-aminopyridine in rats. Stroke. 2000;31(10):2460-2465.
53. Isotani E, Azuma H, Suzuki R, et al. Impaired endothelium-dependent relaxation in rabbit pulmonary artery after subarachnoid hemorrhage. J Cardiovasc Pharmacol. 1996;28(5):639-644.
54. Dignan RJ, Wechsler AS, DeMaria EJ. Coronary vasomotor dysfunction following hemorrhagic shock. J SurgRes. 1992;52:382-388.
55. Hino A, Tokuyama Y, Weir B, et al. Changes in endothelial nitric oxide synthase mRNA during vasospasm after subarachnoid hemorrhage in monkeys. Neurosurgery. 1996;39(3):562-567; discussion: 567-568.
56. Szabo C, Csaki C, Benyo Z, et al. Role of the L-arginine-nitric oxide pathway in the changes in cerebrovascular reactivity following hemorrhagic hypotension and retransfusion. Circ Shock. 1992;37(4):307-316.
57. Bauer C, Kuntz W, Ohnsmann F, et al. The attenuation of hepatic microcirculatory alterations by exogenous substitution of nitric oxide by s-nitroso-human albumin after hemorrhagic shock in the rat. Shock. 2004;21(2):165-169.
58. Miyabe M, Yanagi K, Ohshima N, et al. Sodium nitroprusside decreases leukocyte adhesion and emigration after hemorrhagic shock. Anesth Analg. 2002;94(2):296-301.
59. Hierholzer C, Kalff JC, Billiar TR, et al. Induced nitric oxide promotes intestinal inflammation following hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2004;286(2):G225-G233.
60. Hierholzer C, Menezes JM, Ungeheuer A, et al. A nitric oxide scavenger protects against pulmonary inflammation following hemorrhagic shock. Shock. 2002;17(2):98-103.
61. Palmer RM, Bridge L, Foxwell NA, Moncada S. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids. Br J Pharmacol. 1992;105(1):11-12.
62. Chang H, Wu GJ, Wang SM, Hung CR. Plasma endothelin level changes during hemorrhagic shock. J Trauma. 1993;35(6):825-833.
63. Yokoyama Y, Toth B, Kitchens WC, et al. Estradiol's effect on portal response to endothelin-1 after trauma-hemorrhage. J Surg Res. 2004;121(1):25-30.
64. Pannen BH, Bauer M, Noldge-Schomburg GF, et al. Regulation of hepatic blood flow during resuscitation from hemorrhagic shock: role of NO and endothelins. Am J Physiol. 1997;272(6 Pt 2):H2736-H2745.
65. Upperman JS, Deitch EA, Guo W, et al. Post-hemorrhagic shock mesenteric lymph is cytotoxic to endothelial cells and activates neutrophils. Shock. 1998;10(6):407-414.
66. Deitch EA, Adams CA, Lu Q, Xu DZ. Mesenteric lymph from rats subjected to trauma-hemorrhagic shock are injurious to rat pulmonary microvascular endothelial cells as well as human umbilical vein endothelial cells. Shock. 2001;16(4):290-293.
67. Adams CA. Jr., Sambol JT, Xu DZ, et al. Hemorrhagic shock induced up-regulation of P-selectin expression is mediated by factors in mesenteric lymph and blunted by mesenteric lymph duct interruption. J Trauma. 2001;51(4):625-631; discussion: 631-632.
68. Adams CA. Jr., Xu DZ, Lu Q, Deitch EA. Factors larger than 100 kd in post-hemorrhagic shock mesenteric lymph are toxic for endothelial cells. Surgery. 2001;129(3):351-363.
69. Jarrar D, Wang P, Cioffi WG, et al. The female reproductive cycle is an important variable in the response to trauma-hemorrhage. Am J Physiol Heart Circ Physiol. 2000;279(3): H1015-H1021.
70. Adams CA Jr, Magnotti LJ, Xu DZ, et al. Acute lung injury after hemorrhagic shock is dependent on gut injury and sex. Am Surg. 2000;66(10):905-912.
71. Ba ZF, Kuebler JF, Rue LW III, et al. Gender dimorphic tissue perfusion response after acute hemorrhage and resuscitation: role of vascular endothelial cell function. Am J Physiol Heart Circ Physiol. 2003;284(6):H2162-H2169.
72. Mizushima Y, Wang P, Jarrar D, et al. Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals. Ann Surg. 2000;232(5):673-679.
73. Knoferl M, Jarrar D, Angele MK, et al. 17f-estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage. Am J Physiol Cell Physiol. 2001;281:C1131-C1138.
74. Knoferl M, Angele MK, Diodato MD, et al. Female sex hormones regulate macrophage function after trauma-hemorrhage and prevent increased death rate from subsequent sepsis. Ann Surg. 2002;235:105-112.
75. Kuebler JF, Jarrar D, Toth B, et al. Estradiol administration improves splanchnic perfusion following trauma-hemorrhage and sepsis. Arch Surg. 2002;137(1):74-79.
76. Caulin-Glaser T, Garcia-Cardena G, Sarrel P, et al. 17 beta-estradiol regulation of human endothelial cell basal nitric oxide release, independent of cytosolic Ca2+ mobilization. Circ Res. 1997;81(5):885-892.
77. Haynes MP, Sinha D, Russell KS, et al. Membrane estrogen receptor engagement activates endothelial nitric oxide synthase via the PI3-kinase-Akt pathway in human endothelial cells. Circ Res. 2000;87(8):677-682.
78. Dubey RK, Jackson EK, Keller PJ, et al. Estradiol metabolites inhibit endothelin synthesis by an estrogen receptor-independent mechanism. Hypertension. 2001;37(2 Part 2):640-644.
79. Russell KS, Haynes MP, Sinha D, et al. Human vascular endothelial cells contain membrane binding sites for estradiol, which mediate rapid intracellular signaling. Proc Natl Acad Sci USA. 2000;97(11):5930-5395.
80. Simoncini T, Fornari L, Mannella P, et al. Novel non-transcriptional mechanisms for estrogen receptor signaling in the cardiovascular system. Interaction ofestrogen receptor alpha with phosphatidylinositol 3-OH kinase. Steroids. 2002;67(12): 935-939.
81. Darblade B, Pendaries C, Krust A, et al. Estradiol alters nitric oxide production in the mouse aorta through the alpha-, but not beta-, estrogen receptor. Circ Res. 2002;90(4):413-419.
82. Tyree CM, Zou A, Allegretto EA. 17beta-Estradiol inhibits cytokine induction of the human E-selectin promoter. J Steroid Biochem Mol Biol. 2002;80(3):291-297.
83. Wagner AH, Schroeter MR, Hecker M. 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEBJ. 2001;15(12):2121-2130.
84. Si ML, Al-Sharafi B, Lai CC, et al. Gender difference in cytopro-tection induced by estrogen on female and male bovine aortic endothelial cells. Endocrine. 2001;15(3):255-262.
85. Angele MK, Catania RA, Ayala A, et al. Dehydroepiandrosterone: an inexpensive steroid hormone that decreases the mortality due to sepsis following trauma-induced hemorrhage. Arch Surg. 1998;133(12):1281-1288.
86. Jarrar D, Wang P, Cioffi WG, et al. Mechanisms of the salutary effects of dehydroepiandrosterone after trauma-hemorrhage: direct or indirect effects on cardiac and hepatocellular functions? Arch Surg. 2000;135(4):416-422; discussion: 422-423.
87. Shimizu T, Szalay L, Choudhry MA, et al. Mechanism of salutary effects ofandrostenediol on hepatic function after trauma-hemorrhage: role of endothelial and inducible nitric oxide synthase. Am J Physiol Gastrointest Liver Physiol. 2005;288(2):G244-G250.
88. Shimizu T, Choudhry MA, Szalay L, et al. Salutary effects of androstenediol on cardiac function and splanchnic perfusion after trauma-hemorrhage. Am J Physiol Regul Integr Comp Physiol. 2004;287(2):R386-R390.
89. Wichmann MW, Angele MK, Ayala A, et al. Flutamide: a novel agent for restoring the depressed cell-mediated immunity following soft-tissue trauma and hemorrhagic shock. Shock. 1997;8(4):242-248.
90. Angele MK, Wichmann MW, Ayala A, et al. Testosterone receptor blockade after hemorrhage in males. Restoration ofthe depressed immune functions and improved survival following subsequent sepsis. Arch Surg. 1997;132(11):1207-1214.
91. Remmers DE, Wang P, Cioffi WG, et al. Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males. Am J Physiol. 1997;273(6 Pt 2):H2919-H2925.
92. Ba ZF, Yokoyama Y, Toth B, et al. Gender differences in small intestinal endothelial function: inhibitory role of androgens. Am J Physiol Gastrointest Liver Physiol. 2004;286(3):G452-G457.
93. Ba ZF, Wang P, Koo DJ, et al. Attenuation ofvascular endothelial dysfunction by testosterone receptor blockade after trauma and hemorrhagic shock. Arch Surg. 2001;136(10):1158-1163.
94. Karanian JW, Ramwell PW. Effect of gender and sex steroids on the contractile response of canine coronary and renal blood vessels. J Cardiovasc Pharmacol. 1996;27(3):312-319.
95. Nakao J, Change WC, Murota SI, Orimo H. Testosterone inhibits prostacyclin production by rat aortic smooth muscle cells in culture. Atherosclerosis. 1981;39(2):203-209.
96. Rhee P, Morris J, Durham R, et al. Recombinant humanized monoclonal antibody against CD18 (rhuMAb CD18) in traumatic hemorrhagic shock: results of a phase II clinical trial. Traumatic Shock Group. J Trauma. 2000;49(4):611-619; discussion: 619-620.
97. Corso CO, Okamoto S, Ruttinger D, Messmer K. Hypertonic saline dextran attenuates leukocyte accumulation in the liver after hemorrhagic shock and resuscitation. J Trauma. 1999;46(3):417-423.
98. Younes RN, Aun F, Accioly CQ, et al. Hypertonic solutions in the treatment of hypovolemic shock: a prospective, randomized study in patients admitted to the emergency room. Surgery. 1992; 111(4):380-385.